Research

Publications

Below you can find a list of our published research.

6205 results

Cited 11 times since 2012 (0.8 per year) source: EuropePMC

Current problems in cardiology, Volume 37, Issue 1, 1 1 2012, Pages 7-33 Imaging for atrial fibrillation. Leong DP, Delgado V, Bax JJ

Atrial fibrillation (AF) is the most common clinically significant arrhythmia and is associated with considerable increase in morbidity and mortality. Its appropriate evaluation and management are therefore of paramount importance. Cardiac imaging plays a crucial role in this regard. Imaging permits the identification of cardiovascular conditions that predispose to the development and perpetuation of AF. Furthermore, imaging provides important information to refine strategies to prevent thromboe... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Bratislavske lekarske listy, Volume 113, Issue 4, 1 1 2012, Pages 211-213 The evaluation of effects of lornoxicam on blood flow and erythrocyte deformability in comparison with iv paracetamol in rats. Arslan M, Comu FM, Isik B, Atac MS, Yilmaz D

Background: Lornoxicam and iv paracetamol are commonly preferred to be used for postoperative analgesia. Although Aspirin is a well known non-steroid anti-inflammatory drug that decreases the erythrocyte deformability, there is no study comparing lornoxicam and iv paracetamol regarding their effects on erythrocyte deformability recorded in literature. The aim of this study was to compare the effects of lornoxicam and IV paracetamol on blood perfusion and erythrocyte deformability on rats. Method... Abstract

Cited 29 times since 2012 (2.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2012, Pages 46-55 Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. van der Bogt KE, Hellingman AA, Lijkwan MA, Bos EJ, de Vries MR, van Rappard JR, Fischbein MP, Quax PH, Robbins RC, Hamming JF, Wu JC

Objectives: This study aims to provide insight into cellular kinetics using molecular imaging after different transplantation methods of bone marrow-derived mononuclear cells (MNCs) in a mouse model of peripheral artery disease (PAD). Background: MNC therapy is a promising treatment for PAD. Although clinical translation has already been established, there is a lack of knowledge about cell behavior after transplantation and about the mechanism whereby MNC therapy might ameliorate complaints of P... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 17, 1 1 2012, Pages A3767 [Many adults with congenital heart disease are lost to follow up]. Vis JC, Schuuring MJ, van der Velde ET, Engelfriet-Rijk LC, Harms IM, Mantels S, Bouma BJ, Mulder BJ

Objective: Identification of adults with congenital heart disease (CHD) who were lost to cardiological follow-up. Design: Cross-sectional study. Method: Adults with CHD and not under cardiological follow-up were asked via a nationwide publicity campaign to contact the CONCOR (CONgenital CORvitia) project group. Results: A total of 593 patients with mild (85%) to moderate-severe (15%) CHD were registered via the nationwide campaign. Of these patients, 66% were examined within 1 year by a cardiolo... Abstract

Cited 22 times since 2012 (1.6 per year) source: EuropePMC

Journal of hypertension, Volume 30, Issue 1, 1 1 2012, Pages 107-116 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. Kühnast S, van der Hoorn JW, van den Hoek AM, Havekes LM, Liau G, Jukema JW, Princen HM

Objective: Aliskiren is the first commercially available, orally active, direct renin inhibitor approved to treat hypertension. The renin-angiotensin system has been shown to be a significant contributor to the development of hypercholesterolemia-induced atherosclerosis. The aim of this study was to evaluate the antiatherosclerotic and plaque stabilization effects of aliskiren alone and in combination with atorvastatin. Methods: APOE*3Leiden.CETP mice (n = 14-17/group) were fed a western-type di... Abstract

Cited 38 times since 2012 (2.8 per year) source: EuropePMC

International journal for parasitology, Volume 42, Issue 3, 1 1 2012, Pages 269-277 Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors. Meevissen MH, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH

During infection with the blood fluke Schistosoma mansoni, glycan motifs present on glycoproteins of the parasite’s eggs mediate immunomodulatory effects on the host. The recognition of these glycan motifs is primarily mediated by C-type lectin receptors on dendritic cells and other cells of the immune system. However, it is not yet known which individual glycoproteins interact with the different C-type lectin receptors, and which structural components are involved. Here we investigated the stru... Abstract

Cited 37 times since 2011 (2.8 per year) source: EuropePMC

Cardiovascular research, Volume 93, Issue 3, 22 4 2011, Pages 434-444 Connexin43 silencing in myofibroblasts prevents arrhythmias in myocardial cultures: role of maximal diastolic potential. Askar SF, Bingen BO, Swildens J, Ypey DL, van der Laarse A, Atsma DE, Zeppenfeld K, Schalij MJ, de Vries AA, Pijnappels DA

Aims: Arrhythmogenesis in cardiac fibrosis remains incompletely understood. Therefore, this study aims to investigate how heterocellular coupling between cardiomyocytes (CMCs) and myofibroblasts (MFBs) affects arrhythmogeneity of fibrotic myocardial cultures. Potentially, this may lead to the identification of novel anti-arrhythmic strategies. Methods and results: Co-cultures of neonatal rat CMCs and MFBs in a 1:1 ratio were used as a model of cardiac fibrosis, with purified CMC cultures as cont... Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 8, 20 3 2011, Pages 3443-3455 Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA

The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s... Abstract

Cited 50 times since 2011 (3.7 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 83, Issue 2, 9 2 2011, Pages S56-61 Primary cilia as biomechanical sensors in regulating endothelial function. Egorova AD, van der Heiden K, Poelmann RE, Hierck BP

Depending on the pattern of blood flow to which they are exposed and their proliferative status, vascular endothelial cells can present a primary cilium into the flow compartment of a blood vessel. The cilium modifies the response of endothelial cells to biomechanical forces. Shear stress, which is the drag force exerted by blood flow, is best studied in this respect. Here we review the structural composition of the endothelial cilia and the current status of knowledge about the relation between... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 7 1 2011, Pages 456-462 KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipoprotein cholesterol (LDL-C) lowering response to statins, coronary heart disease (CHD) at baseline, or CHD events on trial. We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376... Abstract

Cited 19 times since 2011 (1.4 per year) source: EuropePMC

PloS one, Volume 6, Issue 12, 6 1 2011, Pages e28638 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. Schlick SN, Wood CD, Gunnell A, Webb HM, Khasnis S, Schepers A, West MJ

Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in... Abstract

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 559-564 Prognostic significance of baseline ST-T-wave abnormalities in diagnostic stress echocardiography. Pedone C, Elhendy A, van Domburg RT, Nelwan SP, Biagini E, Di Pasquale G, Bax JJ, Poldermans D

Objective: The aim of this study was to determine whether resting ST-T wave abnormalities (ST-Ta) provide incremental prognostic information in patients with no history of coronary artery disease undergoing dobutamine stress echocardiography (DSE). Methods: We evaluated 1308 consecutive patients without previous myocardial infarction (MI) or revascularization who underwent DSE. Ischemia was defined as new or worsening wall motion abnormalities. End points during follow-up were all-cause death an... Abstract

Cited 12 times since 2011 (0.9 per year) source: EuropePMC

Coronary artery disease, Volume 22, Issue 8, 1 1 2011, Pages 533-536 Distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, Yiu KH, Atary JZ, Delgado V, Holman ER, van der Wall EE, Schuijf JD, Bax JJ, Schalij MJ

Objectives: Data regarding the distribution of vulnerable lesions in the coronary arteries are scarce. The aim was to evaluate the frequency and distribution of culprit lesions in patients with ST-segment elevation acute myocardial infarction. In addition, the location of culprit lesions was related to infarct size. Methods: Consecutive patients (N=1533, mean age 61±12 years) were evaluated. All patients were treated with primary percutaneous coronary intervention and underwent two-dimensional e... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

World journal of surgery, Volume 35, Issue 12, 1 1 2011, Pages 2829-30; author reply 2831 Re: Risk factors for stroke during surgery for carotid body tumors. van der Bogt KE, van Baalen JM, Hamming JF

Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 12, 1 1 2011, Pages 509-513 Advanced therapy for pulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ

Abstract

Cited 65 times since 2011 (4.8 per year) source: EuropePMC

Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ

Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract

Cited 25 times since 2011 (1.9 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 15, Issue 12, 1 1 2011, Pages 2675-2683 Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC

The myocardium of the developing heart tube is covered by epicardium. These epicardial cells undergo a process of epithelial-to-mesenchymal transformation (EMT) and develop into epicardium-derived cells (EPDCs). The ingrowing EPDCs differentiate into several celltypes of which the cardiac fibroblasts form the main group. Disturbance of EMT of the epicardium leads to serious hypoplasia of the myocardium, abnormal coronary artery differentiation and Purkinje fibre paucity. Interestingly, the elect... Abstract

Cited 91 times since 2011 (6.7 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2011, Pages 51-59 Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, van der Geest RJ, Bonetti C, van der Velde ET, de Roos A, Smit JW, Leung DY, Bax JJ, Lamb HJ

Background: Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T(1) mapping is a previously validated imaging technique that can quantify the burden of global and regional interstitial fibrosis. However, the association between MRI T(1) mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown. Methods and results: Fifty diabetic patients with normal LV ejection fraction (EF) and no underlying... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 421-429 Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study. van der Veen BJ, Al Younis I, Ajmone-Marsan N, Westenberg JJ, Bax JJ, Stokkel MP, de Roos A

Purpose: Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony. Methods: For the normal population 80 patients (40 men... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 416-420 Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M

Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascula... Abstract