Research

Publications

Below you can find a list of our published research.

6131 results

Cited 27 times since 2011 (2 per year) source: EuropePMC

BMC geriatrics, Volume 11, 11 2 2011, Pages 39 Delirium risk screening and haloperidol prophylaxis program in hip fracture patients is a helpful tool in identifying high-risk patients, but does not reduce the incidence of delirium. Vochteloo AJ, Moerman S, van der Burg BL, de Boo M, de Vries MR, Niesten DD, Tuinebreijer WE, Nelissen RG, Pilot P

Background: Delirium in patients with hip fractures lead to higher morbidity and mortality. Prevention in high-risk patients by prescribing low dose haloperidol is currently under investigation. Methods: This prospective cohort surveillance assessed hip fracture patients for risk of developing a delirium with the Risk Model for Delirium (RD) score. High-risk patients (score ≥ 5 points) were treated with a prophylactic low-dose of haloperidol according to hospital protocol. Primary outcome was de... Abstract

Cited 34 times since 2011 (2.5 per year) source: EuropePMC

European heart journal, Volume 33, Issue 9, 10 2 2011, Pages 1076-1084 Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis. van der Laan AM, Schirmer SH, de Vries MR, Koning JJ, Volger OL, Fledderus JO, Bastiaansen AJ, Hollander MR, Baggen JM, Koch KT, Baan J, Henriques JP, van der Schaaf RJ, Vis MM, Mebius RE, van der Pouw Kraan TC, Quax PH, Piek JJ, Horrevoets AJ, van Royen N

Aims: In patients with obstructive coronary artery disease (CAD), the growth of collateral arteries, i.e. arteriogenesis, can preserve myocardial tissue perfusion and function. Monocytes modulate this process, supplying locally the necessary growth factors and degrading enzymes. Knowledge on factors involved in human arteriogenesis is scarce. Thus, the aim of the present study is to identify targets in monocytes that are critical for arteriogenesis in patients with CAD. Methods and results: A to... Abstract

Cited 26 times since 2011 (1.9 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 10, 6 1 2011, Pages 1126-1133 Comprehensive assessment of changes in left atrial volumes and function after ST-segment elevation acute myocardial infarction: role of two-dimensional speckle-tracking strain imaging. Antoni ML, Ten Brinke EA, Marsan NA, Atary JZ, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

Background: Left atrial (LA) size has been associated with adverse outcome in patients after acute myocardial infarction. However, data about the occurrence of late LA enlargement and changes in LA function during follow-up are scarce. The purpose of the current study was to evaluate changes in LA size and function during 1-year follow-up. Methods: The study population comprised 407 patients with acute myocardial infarction who were treated with primary percutaneous coronary intervention. At bas... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 1, 5 1 2011, Pages 10-17 Catheter ablation of ventricular tachycardia after left ventricular reconstructive surgery for ischemic cardiomyopathy. Wijnmaalen AP, Roberts-Thomson KC, Steven D, Klautz RJ, Willems S, Schalij MJ, Stevenson WG, Zeppenfeld K

Background: After surgical ventricular restoration (SVR) for ischemic cardiomyopathy, ventricular tachycardias (VTs) are an important reason for postoperative morbidity and mortality. Objective: The purpose of this study was to elucidate the VT substrate, VT characteristics, and outcome of radiofrequency catheter ablation (RFCA) in patients with VT after SVR. Methods: Twelve (3%) of 416 patients referred for RFCA for VT after myocardial infarction in three centers had undergone SVR. After induct... Abstract

Cited 94 times since 2011 (6.9 per year) source: EuropePMC

European heart journal, Volume 33, Issue 16, 4 1 2011, Pages 2098-2108 Aldosterone promotes atrial fibrillation. Reil JC, Hohl M, Selejan S, Lipp P, Drautz F, Kazakow A, Münz BM, Müller P, Steendijk P, Reil GH, Allessie MA, Böhm M, Neuberger HR

Aims: Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF). However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology. Methods: Osmotic mini-pumps delivering 1.5 µg/h aldosterone were implanted subcutaneously in rats (Aldo). Rats without aldosterone treatment served as controls. Afte... Abstract

Cited 93 times since 2011 (6.8 per year) source: EuropePMC

Circulation, Volume 124, Issue 8, 1 1 2011, Pages 912-919 Cardiac resynchronization therapy as a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk. van Bommel RJ, Marsan NA, Delgado V, Borleffs CJ, van Rijnsoever EP, Schalij MJ, Bax JJ

Background: Functional mitral regurgitation (MR) is a common finding in heart failure patients with dilated cardiomyopathy and has important prognostic implications. However, the increased operative risk of these patients may result in low referral or high denial rate for mitral valve surgery. Cardiac resynchronization therapy (CRT) has been shown to have a favorable effect on MR. Aims of this study were to (1) evaluate CRT as a therapeutic option in heart failure patients with functional MR and... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 15, 1 1 2011, Pages 1268-1276 Pharmacogenetics of antiplatelet therapy: ready for clinical application? Verschuren JJ, Jukema JW

Abstract

Cited 35 times since 2011 (2.6 per year) source: EuropePMC

Journal of the American Academy of Dermatology, Volume 65, Issue 2, 1 1 2011, Pages 420-421 Atenolol: a promising alternative to propranolol for the treatment of hemangiomas. Raphaël MF, de Graaf M, Breugem CC, Pasmans SGMA, Breur JMPJ

Abstract

Cited 17 times since 2011 (1.2 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 7, Issue 4, 1 1 2011, Pages 505-516 Clinical performance of drug-eluting stents with biodegradable polymeric coating: a meta-analysis and systematic review. Ahmed TA, Bergheanu SC, Stijnen T, Plevier JW, Quax PH, Jukema JW

Aims: Different biodegradable-polymer drug-eluting stents have not yet been systematically analysed. We sought to; 1) evaluate the risk of target lesion revascularisation (TLR) and definite stent thrombosis (DST) among different groups of biodegradable-polymer (BioPol) DES, and 2) to compare them with permanent polymer (PermPol) DES. Methods and results: We searched PubMed and relevant sources from January 2005 until October 2010. Inclusion criteria were (a) Implantation of a drug-eluting stent... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 34, Issue 2, 1 1 2011, Pages 270-278 Automated regional wall motion abnormality detection by combining rest and stress cardiac MRI: correlation with contrast-enhanced MRI. Suinesiaputra A, Frangi AF, Kaandorp TA, Lamb HJ, Bax JJ, Reiber JH, Lelieveldt BP

Purpose: To correlate an automated regional wall motion abnormality (RWMA) detection method based on combined rest and dobutamine-stress cardiac MRI with the assessment of myocardial infarction from contrast-enhanced MRI (CE-MRI), and to demonstrate that adding stress data improves the detection of scar segments compared with rest data alone. Materials and methods: An automated RWMA detection method was built based on a statistical model of normokinetic myocardium from 41 healthy volunteers. The... Abstract

Cited 72 times since 2011 (5.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 4, 1 1 2011, Pages 685-694 SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony. Chen J, Garcia EV, Bax JJ, Iskandrian AE, Borges-Neto S, Soman P

Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical development and clinical evaluation. This article reviews the background, the technical and clinical characteristics, and evolving clinical applications of phase analysis of gated SPECT MPI in patients requiring cardiac resynchronization therapy or impla... Abstract

Cited 138 times since 2011 (10.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 58, Issue 10, 1 1 2011, Pages 995-1000 Implantation-related complications of implantable cardioverter-defibrillators and cardiac resynchronization therapy devices: a systematic review of randomized clinical trials. van Rees JB, de Bie MK, Thijssen J, Borleffs CJ, Schalij MJ, van Erven L

The number of implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy (CRT) implantations is increasing drastically worldwide, and hence, the number of implanting centers is also increasing. Despite abundant data on the beneficial effect of these devices, little is known regarding safety and complication rates. Eleven ICD and 7 CRT trials were systematically reviewed to provide data on the frequency of in-hospital mortality and complications related to the implantation... Abstract

Cited 47 times since 2011 (3.5 per year) source: EuropePMC

European heart journal, Volume 33, Issue 2, 30 5 2011, Pages 165-175 A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application? Verschuren JJ, Trompet S, Wessels JA, Guchelaar HJ, de Maat MP, Simoons ML, Jukema JW

Pharmacogenetics is the search for heritable genetic polymorphisms that influence responses to drug therapy. The most important application of pharmacogenetics is to guide choosing agents with the greatest potential of efficacy and smallest risk of adverse drug reactions. Many studies focusing on drug-gene interactions have been published in recent years, some of which led to adaptation of FDA recommendations, indicating that we are on the verge of the clinical application of genetic information... Abstract

Cited 44 times since 2011 (3.2 per year) source: EuropePMC

American journal of obstetrics and gynecology, Volume 206, Issue 1, 30 5 2011, Pages 89.e1-5 Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer. Hutteman M, van der Vorst JR, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objectives: Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Study design: Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using (99m)technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 50... Abstract

Brain & development, Volume 34, Issue 4, 23 4 2011, Pages 298-301 Cerebrospinal fluid apolipoprotein E levels in subacute sclerosing panencephalitis. Yüksel D, Ichiyama T, Yilmaz D, Anlar B

Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis (SSPE) cases. NFTs contain paired helical filaments formed by hyperphosphorylated tau. The intraneuronal tau metabolism and the rate of formation of paired helical filaments can be regulated by interactions between tau and isoforms of Apolipoprotein E (Apo E). Tau binds in vitro to Apo E3, interferes with the hyperphosphorylation of tau and may reduce the formation of NFTs. We investigated cerebrospinal... Abstract

Cited 19 times since 2011 (1.4 per year) source: Scopus

European heart journal, Volume 32, Issue 22, 23 4 2011, Pages 2806-2813 Influence of left ventricular geometry and function on aortic annular dimensions as assessed with multi-detector row computed tomography: implications for transcatheter aortic valve implantation. Ng AC, Yiu KH, Ewe SH, van der Kley F, Bertini M, de Weger A, de Roos A, Leung DY, Schuijf JD, Schalij MJ, Bax JJ, Delgado V

Aims: Evaluate changes in aortic annular dimensions in relation to severe aortic stenosis (AS) and left ventricular (LV) dysfunction. Methods and results: Mean aortic annular diameters and geometries were compared between 90 severe AS patients and 111 controls by multi-detector row computed tomography (MDCT). All severe AS patients were also dichotomized into two groups based on the presence of preserved (≥ 50%) or impaired ( Abstract

Cited 9 times since 2011 (0.7 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 7, 23 4 2011, Pages 968-972 Prognostic value of renal dysfunction for the prediction of outcome versus results of computed tomographic coronary angiography. Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, van Velzen JE, Boogers MJ, Roos CJ, de Bie MK, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, de Roos A, Kaufmann PA, Bax JJ, Jukema JW

Chronic kidney disease (CKD) is associated with cardiovascular (CV) events caused by advanced atherosclerosis. Computed tomographic coronary angiography (CTA) can accurately diagnose coronary artery disease (CAD) and predict CV outcomes. The aim of the present study was to evaluate whether moderate CKD provides prognostic information for CV events in patients undergoing CTA. In total 885 patients with suspected CAD underwent CTA and were stratified to moderate CKD (85 patients) or no CKD (770 pa... Abstract

Cited 33 times since 2011 (2.4 per year) source: EuropePMC

Journal of biomechanics, Volume 44, Issue 13, 22 4 2011, Pages 2376-2382 Initial stress in biomechanical models of atherosclerotic plaques. Speelman L, Akyildiz AC, den Adel B, Wentzel JJ, van der Steen AF, Virmani R, van der Weerd L, Jukema JW, Poelmann RE, van Brummelen EH, Gijsen FJ

Rupture of atherosclerotic plaques is the underlying cause for the majority of acute strokes and myocardial infarctions. Rupture of the plaque occurs when the stress in the plaque exceeds the strength of the material locally. Biomechanical stress analyses are commonly based on pressurized geometries, in most cases measured by in-vivo MRI. The geometry is therefore not stress-free. The aim of this study is to identify the effect of neglecting the initial stress state on the plaque stress distribu... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 22, Issue 12, 21 3 2011, Pages 1346-1350 Primary prevention implantable cardioverter defibrillator recipients: the need for defibrillator back-up after an event-free first battery service-life. Van Welsenes GH, Van Rees JB, Thijssen J, Trines SA, Van Erven L, Schalij MJ, Borleffs CJ

Introduction: In primary prevention implantable cardioverter defibrillator (ICD) patients, the relatively low incidence of ventricular arrhythmias (VA) combined with the limited battery service-life potentially results in a large group of patients who have had no benefit of the ICD during first service-life. Data on the occurrence of VA after device replacement remain scarce. The purpose of this study was to give clinicians better insight in the dilemma whether or not to replace an ICD after an... Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

Atherosclerosis, Volume 218, Issue 2, 20 3 2011, Pages 457-463 ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting. Regieli JJ, Doevendans PA, Grobbee DE, Zwinderman AH, van der Graaf Y, Kastelein JJ, Jukema JW

Objectives: We prospectively investigated the effects of ATP-binding cassette protein-1 (ABCA1) variants on long-term clinical outcome in patients with coronary artery disease (CAD). Background: ABCA1 is implicated in the etiology of atherothrombosis and may offer a target to reduce cardiovascular risk. However, the impact of ABCA1 on recurrent cardiovascular disease in a secondary prevention setting is as of yet unknown. Methods: We studied cause-specific 10-year mortality and quantitative coro... Abstract