6128 results
Cited 45 times since 2010 (3 per year)
source: EuropePMC
Journal of innate immunity,
Volume 2, Issue 4, 30 5 2010, Pages 307-315
Endogenous inflammatory molecules engage Toll-like receptors in cardiovascular disease.
Ionita MG, Arslan F, de Kleijn DP, Pasterkamp G
Innate immunity is important in the pathogenesis and progression of cardiovascular disease. Innate immune cells express various pattern-recognition receptors, among which also Toll-like receptors (TLRs). TLRs occur in atherosclerotic lesions where they are triggered by both exogenous (bacterial and viral pathogens) and endogenous (tissue damage-associated) molecules. Several endogenous TLR activators are described in relation to atherosclerotic disease or ischemia-induced cardiac injury. Experim...
Abstract
Cited 39 times since 2010 (2.6 per year)
source: EuropePMC
Clinical journal of the American Society of Nephrology : CJASN,
Volume 5, Issue 7, 29 5 2010, Pages 1198-1204
Temporary perioperative decline of renal function is an independent predictor for chronic kidney disease.
van Kuijk JP, Flu WJ, Chonchol M, Hoeks SE, Winkel TA, Verhagen HJ, Bax JJ, Poldermans D
Background and objectives: Acute kidney injury is an independent predictor of short- and long-term survival; however, data on the relationship between reversible transitory decline of kidney function and chronic kidney disease (CKD) are lacking. We assessed the prognostic value of temporary renal function decline on the development of long-term CKD. Design, setting, participants, & measurements: The study included 1308 patients who were undergoing major vascular surgery (aortic aneurysm repa...
Abstract
Cited 115 times since 2010 (7.7 per year)
source: EuropePMC
European heart journal,
Volume 31, Issue 13, 27 4 2010, Pages 1640-1647
Prognostic importance of strain and strain rate after acute myocardial infarction.
Antoni ML, Mollema SA, Delgado V, Atary JZ, Borleffs CJ, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Aims: Recently, strain and strain rate have been introduced as novel parameters reflecting left ventricular (LV) function. The purpose of the current study was to assess the prognostic importance of strain and strain rate after acute myocardial infarction (AMI). Methods and results: A total of 659 patients after AMI were evaluated. Baseline echocardiography was performed to assess LV function with traditional parameters and strain and strain rate. During follow-up, 51 patients (8%) reached the p...
Abstract
Cited 47 times since 2010 (3.2 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 33, Issue 8, 27 4 2010, Pages 1013-1019
Recurrent implantable cardioverter-defibrillator replacement is associated with an increasing risk of pocket-related complications.
Borleffs CJ, Thijssen J, de Bie MK, van Rees JB, van Welsenes GH, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ
Background: Despite beneficial effects of implantable cardioverter-defibrillator (ICD) therapy, limited service life results in replacement within the majority of patients. Data concerning the effect of replacement procedures on the occurrence of pocket-related adverse events are scarce. In this study, the requirement for pocket-related surgical re-interventions following ICD treatment and the effect of device replacement were evaluated. Methods: From 1992 to 2008, 2,415 patients receiving an IC...
Abstract
Cited 26 times since 2010 (1.7 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 43, Issue 4, 24 4 2010, Pages 294-301
The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram.
Schreurs CA, Algra AM, Man SC, Cannegieter SC, van der Wall EE, Schalij MJ, Kors JA, Swenne CA
Background and purpose: The spatial QRS-T angle (SA), a predictor of sudden cardiac death, is a vectorcardiographic variable. Gold standard vertorcardiograms (VCGs) are recorded by using the Frank electrode positions. However, with the commonly available 12-lead ECG, VCGs must be synthesized by matrix multiplication (inverse Dower matrix/Kors matrix). Alternatively, Rautaharju proposed a method to calculate SA directly from the 12-lead ECG. Neither spatial angles computed by using the inverse Do...
Abstract
Cited 24 times since 2010 (1.6 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 30, Issue 8, 22 4 2010, Pages 1591-1597
6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages.
Pols TW, Bonta PI, Pires NM, Otermin I, Vos M, de Vries MR, van Eijk M, Roelofsen J, Havekes LM, Quax PH, van Kuilenburg AB, de Waard V, Pannekoek H, de Vries CJ
Objective: 6-Mercaptopurine (6-MP), the active metabolite of the immunosuppressive prodrug azathioprine, is commonly used in autoimmune diseases and transplant recipients, who are at high risk for cardiovascular disease. Here, we aimed to gain knowledge on the action of 6-MP in atherosclerosis, with a focus on monocytes and macrophages. Methods and results: We demonstrate that 6-MP induces apoptosis of THP-1 monocytes, involving decreased expression of the intrinsic antiapoptotic factors B-cell...
Abstract
Cited 22 times since 2010 (1.5 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 37, Issue 9, 22 4 2010, Pages 1698-1705
Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability.
Scholte AJ, Schuijf JD, Delgado V, Kok JA, Bus MT, Maan AC, Stokkel MP, Kharagitsingh AV, Dibbets-Schneider P, van der Wall EE, Bax JJ
Purpose: The purpose of this study was to evaluate the prevalence of cardiac autonomic neuropathy (CAN) in a cohort of patients with type 2 diabetes, truly asymptomatic for coronary artery disease (CAD), using heart rate variability (HRV) and (123)I-metaiodobenzylguanidine ((123)I-mIBG) myocardial scintigraphy. Methods: The study group comprised 88 patients with type 2 diabetes prospectively recruited from an outpatient diabetes clinic. In all patients myocardial perfusion scintigraphy, CAN by H...
Abstract
Cited 84 times since 2010 (5.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 11, 20 3 2010, Pages 872-878
The emerging burden of hospital admissions of adults with congenital heart disease.
Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ
Objective: To assess the extent and the characteristics of hospital admissions in registered adult patients with congenital heart disease. Design: Observational cohort study. Setting: The Netherlands. Patients: 5798 adult patients with congenital heart disease from the Dutch CONCOR national registry linked to the Dutch National Medical Registration (Prismant). Main outcome measures: All hospital admissions from the years 2001 up until 2006. Results: During 28 990 patient-years, 2908 patients (50...
Abstract
Cited 45 times since 2010 (3 per year)
source: EuropePMC
Circulation,
Volume 121, Issue 17, 19 3 2010, Pages 1887-1895
Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate.
Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K
Background: Reperfusion therapy during acute myocardial infarction results in myocardial salvage and improved ventricular function but may also influence the arrhythmogenic substrate for ventricular tachycardia (VT). This study used electroanatomic mapping and infarct histology to assess the impact of reperfusion on the substrate and on VT characteristics late after acute myocardial infarction. Methods and results: The study population consisted of 36 patients (32 men; age, 63+/-15 years) referr...
Abstract
Cited 250 times since 2010 (16.8 per year)
source: EuropePMC
Circulation,
Volume 121, Issue 17, 19 3 2010, Pages 1941-1950
Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study.
Hellings WE, Peeters W, Moll FL, Piers SR, van Setten J, Van der Spek PJ, de Vries JP, Seldenrijk KA, De Bruin PC, Vink A, Velema E, de Kleijn DP, Pasterkamp G
Background: Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors. The atherosclerotic plaque composition is thought to be an important determinant of acute cardiovascular events, but no prospective studies have been performed. The objective of the present study was to investigate whether atherosclerotic plaque composition is associated with the occurrence of future vascular events. Methods a...
Abstract
Cited 17 times since 2010 (1.1 per year)
source: EuropePMC
Leukemia research,
Volume 34, Issue 10, 14 2 2010, Pages 1275-1281
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia.
Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinç E
It is now well established that genetic polymorphisms impairing the DNA repair capacity can disrupt the genomic integrity and potentially modulate individual's susceptibility to various cancers. In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients. For Ar...
Abstract
Cited 207 times since 2010 (13.9 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 24, Issue 9, 12 2 2010, Pages 3135-3144
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology.
Talens RP, Boomsma DI, Tobi EW, Kremer D, Jukema JW, Willemsen G, Putter H, Slagboom PE, Heijmans BT
The prospect of finding epigenetic risk factors for complex diseases would be greatly enhanced if DNA from existing biobanks, which is generally extracted from whole blood, could be used to perform epigenetic association studies. We characterized features of DNA methylation at 16 candidate loci, 8 of which were imprinted, in DNA samples from the Netherlands Twin Register biobank. Except for unmethylated or fully methylated sites, CpG methylation varied considerably in a sample of 30 unrelated in...
Abstract
Cited 12 times since 2010 (0.8 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 40, Issue 1, 10 2 2010, Pages 65-70
Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.
Bosman WM, Vlot J, van der Steenhoven TJ, van den Berg O, Hamming JF, de Vries AC, Brom HL, Jacobs MJ
Objective: This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model. Design: Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created. Material: The formulation used in the experiments consisted of a two-component addition-cure...
Abstract
Cited 15 times since 2010 (1 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 140, Issue 6, 9 2 2010, Pages 1338-1344
Long-term effects of surgical ventricular restoration with additional restrictive mitral annuloplasty and/or coronary artery bypass grafting on left ventricular function: six-month follow-up by pressure-volume loops.
ten Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Schalij MJ, van der Wall EE, Versteegh MI, Dion RA, Steendijk P
Objectives: Previous studies demonstrated beneficial short-term effects of surgical ventricular restoration on mechanical dyssynchrony and left ventricular function and improved midterm and long-term clinical parameters. However, long-term effects on systolic and diastolic left ventricular function are still largely unknown. Methods: We studied 9 patients with ischemic dilated cardiomyopathy who underwent surgical ventricular restoration with additional restrictive mitral annuloplasty and/or cor...
Abstract
Cited 35 times since 2010 (2.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 17, Issue 3, 9 2 2010, Pages 470-478
Diagnostic accuracy of 64-slice computed tomography coronary angiography for the detection of in-stent restenosis: a meta-analysis.
Carrabba N, Schuijf JD, de Graaf FR, Parodi G, Maffei E, Valenti R, Palumbo A, Weustink AC, Mollet NR, Accetta G, Cademartiri F, Antoniucci D, Bax JJ
Background: We sought to evaluate the diagnostic accuracy of 64-slice multi-detector row computed tomography (MDCT) compared with invasive coronary angiography for in-stent restenosis (ISR) detection. Methods: MEDLINE, Cochrane library, and BioMed Central database searches were performed until April 2009 for original articles. Inclusion criteria were (1) 64-MDCT was used as a diagnostic test for ISR, with >50% diameter stenosis selected as the cut-off criterion for significant ISR, using inva...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
Circulation,
Volume 121, Issue 13, 1 1 2010, Pages e261-2
Images in cardiovascular medicine. Direct endoscopic visual assessment of a transcatheter aortic valve implantation and performance in the Physioheart, an isolated working heart platform.
de Weger A, van Tuijl S, Stijnen M, Steendijk P, de Hart J
Abstract
Cited 19 times since 2010 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 8, 1 1 2010, Pages 621-624
22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia.
van Engelen K, Topf A, Keavney BD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ
Background: Three quarters of patients with 22q11.2 Deletion Syndrome (22q11.2DS) have congenital heart disease (CHD), typically conotruncal heart defects. Although it is currently common practice to test all children with typical CHD for 22q11.2DS, many adult patients have not been tested in the past and therefore 22q11.2DS might be under-recognised in adults. Objectives: To determine the prevalence of 22q11.2DS in adults with tetralogy of Fallot (TOF) and pulmonary atresia (PA)/ventricular sep...
Abstract
Cited 4 times since 2010 (0.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 7, 1 1 2010, Pages 560-572
Non-invasive imaging: Non-invasive assessment of coronary artery disease in diabetes.
Van de Veire NR, Djaberi R, Schuijf JD, Bax JJ
Abstract
Cited 26 times since 2010 (1.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 3, Issue 4, 1 1 2010, Pages 429-439
Recent developments in heart failure imaging.
Marwick TH, Raman SV, Carrió I, Bax JJ
Despite the central role of echocardiography in its primary assessment, heart failure is a condition in which access to multiple cardiovascular imaging modalities is important. A number of important observations relative to this topic have been made in the last year, including the assessment of left ventricular synchrony, myocardial mechanics, heart failure with preserved ejection fraction, metabolic imaging, assessment of myocardial viability, and fusion imaging.
Abstract
Cited 95 times since 2010 (6.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 55, Issue 15, 1 1 2010, Pages 1611-1618
Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy.
Akdim F, Stroes ES, Sijbrands EJ, Tribble DL, Trip MD, Jukema JW, Flaim JD, Su J, Yu R, Baker BF, Wedel MK, Kastelein JJ
Objectives: The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy. Background: Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated significant reductions in apo B and low-density lipoprotein (LDL) cholesterol in Phase 1 clinical trials in healthy volunteers. Methods: A randomized, placebo-controlled, dose-escalation Phase 2 study was designed to evaluate the effects of mipomersen in...
Abstract
