Research

Publications

Below you can find a list of our published research.

7995 results

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

PloS one, Volume 9, Issue 2, 21 3 2014, Pages e88984 Circulating immunoglobulins are not associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis. Willems S, van der Velden D, Quax PH, de Borst GJ, de Vries JP, Moll FL, Kuiper J, Toes RE, de Jager SC, de Kleijn DP, Hoefer IE, Pasterkamp G, Bot I

Background: Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activate mast cells during the progression and destabilization of atherosclerotic lesions remain unidentified. Mast cells can be activated by immunoglobulins and in the present study, we aimed to... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 47, Issue 5, 20 3 2014, Pages 479-486 Differences in mortality, risk factors, and complications after open and endovascular repair of ruptured abdominal aortic aneurysms. von Meijenfeldt GC, Ultee KH, Eefting D, Hoeks SE, ten Raa S, Rouwet EV, Hendriks JM, Verhagen HJ, Bastos Goncalves FM

Objective/background: Endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysm (rAAA) has faced resistance owing to the marginal evidence of benefit over open surgical repair (OSR). This study aims to determine the impact of treatment modality on early mortality after rAAA, and to assess differences in postoperative complications and long-term survival. Methods: Patients treated between January 2000 and June 2013 were identified. The primary endpoint was early mortality. Second... Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

Obesity (Silver Spring, Md.), Volume 22, Issue 6, 18 3 2014, Pages 1553-1559 Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation. Hillebrand S, de Mutsert R, Christen T, Maan AC, Jukema JW, Lamb HJ, de Roos A, Rosendaal FR, den Heijer M, Swenne CA, NEO Study Group

Objective: Obesity is associated with sympathetic activation, but the role of different fat depots is unclear. The association between body fat, specifically visceral fat, and electrocardiographic measures of sympathetic activation in a population with structurally normal hearts was investigated. Methods: In this cross-sectional baseline analysis of the Netherlands Epidemiology of Obesity study, body fat percentage was assessed with BIA and abdominal subcutaneous (SAT) and visceral adipose tissu... Abstract

Cited 25 times since 2014 (2.3 per year) source: EuropePMC

European heart journal, Volume 35, Issue 22, 16 3 2014, Pages 1479-1485 Radio-frequency ablation as primary management of well-tolerated sustained monomorphic ventricular tachycardia in patients with structural heart disease and left ventricular ejection fraction over 30%. Maury P, Baratto F, Zeppenfeld K, Klein G, Delacretaz E, Sacher F, Pruvot E, Brigadeau F, Rollin A, Andronache M, Maccabelli G, Gawrysiak M, Brenner R, Forclaz A, Schlaepfer J, Lacroix D, Duparc A, Mondoly P, Bouisset F, Delay M, Hocini M, Derval N, Sadoul N, Magnin-Poull I, Klug D, Haïssaguerre M, Jaïs P, Della Bella P, De Chillou C

Aims: Patients with well-tolerated sustained monomorphic ventricular tachycardia (SMVT) and left ventricular ejection fraction (LVEF) over 30% may benefit from a primary strategy of VT ablation without immediate need for a 'back-up' implantable cardioverter-defibrillator (ICD). Methods and results: One hundred and sixty-six patients with structural heart disease (SHD), LVEF over 30%, and well-tolerated SMVT (no syncope) underwent primary radiofrequency ablation without ICD implantation... Abstract

Cited 34 times since 2014 (3.1 per year) source: EuropePMC

Injury, Volume 45, Issue 7, 15 3 2014, Pages 1028-1034 Systematic review of the prevalence and characteristics of battle casualties from NATO coalition forces in Iraq and Afghanistan. Hoencamp R, Vermetten E, Tan EC, Putter H, Leenen LP, Hamming JF

Background: The North Atlantic Treaty Organization (NATO) coalition forces remain heavily committed on combat operations overseas. Understanding the prevalence and characteristics of battlefield injury of coalition partners is vital to combat casualty care performance improvement. The aim of this systematic review was to evaluate the prevalence and characteristics of battle casualties from NATO coalition partners in Iraq and Afghanistan. The primary outcome was mechanism of injury and the second... Abstract

Cited 29 times since 2014 (2.6 per year) source: EuropePMC

Annals of surgical oncology, Volume 21 Suppl 4, 11 2 2014, Pages S528-37 Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL

Background: Irradical tumor resections and iatrogenic ureteral injury remain a significant problem during lower abdominal surgery. The aim of the current study was to intraoperatively identify both colorectal tumors and ureters in subcutaneous and orthotopic animal models using cRGD-ZW800-1 and near-infrared (NIR) fluorescence. Methods: The zwitterionic fluorophore ZW800-1 was conjugated to the tumor specific peptide cRGD (targeting integrins) and to the a-specific peptide cRAD. One nmol cRGD-ZW... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

Journal of the American Academy of Dermatology, Volume 70, Issue 5, 10 2 2014, Pages 893-898 E-learning enables parents to assess an infantile hemangioma. de Graaf M, Knol MJ, Totté JE, van Os-Medendorp H, Breugem CC, Pasmans SG

Background: Infantile hemangiomas (IH) at risk for complications need to be recognized early. Objective: We sought to determine if parents are able to assess, after e-learning, whether their child has an IH, is at risk for complications, and needs to be seen (urgently) by a specialist. Methods: This was a prospective study of 158 parents participating in an IH e-learning module. Parents were asked to assess their child's skin abnormality. A dermatologist answered the same questions (by e-co... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

PloS one, Volume 9, Issue 2, 10 2 2014, Pages e86665 Temporal trends of system of care for STEMI: insights from the Jakarta Cardiovascular Care Unit Network System. Dharma S, Siswanto BB, Firdaus I, Dakota I, Andriantoro H, Wardeh AJ, van der Laarse A, Jukema JW

Aim: Guideline implementation programs are of paramount importance in optimizing acute ST-elevation myocardial infarction (STEMI) care. Assessment of performance indicators from a local STEMI network will provide knowledge of how to improve the system of care. Methods and results: Between 2008-2011, 1505 STEMI patients were enrolled. We compared the performance indicators before (n = 869) and after implementation (n = 636) of a local STEMI network. In 2011 (after introduction of STEMI networking... Abstract

Cited 34 times since 2014 (3.1 per year) source: EuropePMC

Circulation research, Volume 114, Issue 6, 7 1 2014, Pages 993-1003 Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts. Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S

Rationale: β-Adrenoceptor activation contributes to sudden death risk in heart failure. Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs). Objective: To assess the molecular mechanisms of IKs downregulation caused by chronic β-adrenergic activation, particularly the role of exchange protein directly activated by cAMP (Epac). Methods and results: Isolated guinea pig left ventricular... Abstract

Cited 35 times since 2014 (3.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 3, 6 1 2014, Pages 549-558 Global longitudinal strain and left atrial volume index improve prediction of appropriate implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy patients. Debonnaire P, Thijssen J, Leong DP, Joyce E, Katsanos S, Hoogslag GE, Schalij MJ, Atsma DE, Bax JJ, Delgado V, Marsan NA

Accurate predictors of appropriate implantable cardioverter defibrillator (ICD) therapy in hypertrophic cardiomyopathy (HCM) patients are lacking. Both left atrial volume index (LAVI) and global longitudinal strain (GLS) have been proposed as prognostic markers in HCM patients. The specific value of LAVI and GLS to predict appropriate ICD therapy in high-risk HCM patients was studied. LAVI and 2-dimensional speckle tracking-derived GLS were assessed in 92 HCM patients undergoing ICD implantation... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 15, Issue 7, 4 1 2014, Pages 832 CoreValve stent frame misdeployment and increased transvalvular gradient. Kamperidis V, van der Kley F, Katsanos S, Delgado V

Abstract

Cited 89 times since 2014 (8 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 16, Issue 5, 4 1 2014, Pages 681-688 Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the wireless stimulation endocardially for CRT (WiSE-CRT) study. Auricchio A, Delnoy PP, Butter C, Brachmann J, Van Erven L, Spitzer S, Moccetti T, Seifert M, Markou T, Laszo K, Regoli F, Collaborative Study Group

Aims: Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) patients enroled into the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study. Methods and results: Seventeen HF patients were... Abstract

Cited 13 times since 2014 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 4, 4 1 2014, Pages 713-720 Impact of right ventricular dyssynchrony on left ventricular performance in patients with pulmonary hypertension. Haeck ML, Höke U, Marsan NA, Holman ER, Wolterbeek R, Bax JJ, Schalij MJ, Vliegen HW, Delgado V

Pulmonary hypertension has been associated with right ventricular (RV) dyssynchrony which may induce left ventricular (LV) dysfunction and dyssynchrony through ventricular interdependence. The present study evaluated the influence of RV dyssynchrony on LV performance in patients with pulmonary hypertension. One hundred and seven patients with pulmonary hypertension (age 63 ± 14 years, systolic pulmonary arterial pressure 60 ± 19 mmHg) and LV ejection fraction (EF) >35% were evaluated. Ventric... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 77-79 ST-segment elevation associated with allergic reaction to echocardiographic contrast agent administration. van Ginkel A, Sorgdrager B, de Graaf MA, Karalis I, Ajmone Marsan N

We report a case of an allergic reaction after the administration of an echocardiographic contrast agent which resulted in ST-segment elevation. Hypersensitivity and allergic reactions are known causes of acute cardiovascular events. However, only limited reports are available which suggest the exact mechanism of the occurrence of angina or myocardial infarction during severe allergic reactions. In our case, through invasive imaging (coronary angiography and IVUS) we have shown for the first tim... Abstract

Cited 12 times since 2014 (1.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 64-69 Antithrombotic therapy in patients undergoing TAVI: an overview of Dutch hospitals. Nijenhuis VJ, Stella PR, Baan J, Brueren BR, de Jaegere PP, den Heijer P, Hofma SH, Kievit P, Slagboom T, van den Heuvel AF, van der Kley F, van Garsse L, van Houwelingen KG, Van't Hof AW, Ten Berg JM

Purpose: To assess current antithrombotic treatment strategies in the Netherlands in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: For every Dutch hospital performing TAVI (n = 14) an interventional cardiologist experienced in performing TAVI was interviewed concerning heparin, aspirin, thienopyridine and oral anticoagulation treatment in patients undergoing TAVI. Results: The response rate was 100 %. In every centre, a protocol for antithrombotic treatment after T... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 63, Issue 6, 1 1 2014, Pages 570-602 Highlights of the year in JACC 2013. DeMaria AN, Adler ED, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S

Abstract

Cited 119 times since 2014 (10.7 per year) source: EuropePMC

European heart journal, Volume 35, Issue 22, 31 5 2014, Pages 1466-1478 The atrial fibrillation ablation pilot study: a European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association. Arbelo E, Brugada J, Hindricks G, Maggioni AP, Tavazzi L, Vardas P, Laroche C, Anselme F, Inama G, Jais P, Kalarus Z, Kautzner J, Lewalter T, Mairesse GH, Perez-Villacastin J, Riahi S, Taborsky M, Theodorakis G, Trines SA, Atrial Fibrillation Ablation Pilot Study Investigators

Aims: The Atrial Fibrillation Ablation Pilot Study is a prospective registry designed to describe the clinical epidemiology of patients undergoing an atrial fibrillation (AFib) ablation, and the diagnostic/therapeutic processes applied across Europe. The aims of the 1-year follow-up were to analyse how centres assess in routine clinical practice the success of the procedure and to evaluate the success rate and long-term safety/complications. Methods and results: Seventy-two centres in 10 Europea... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 3, 31 5 2014, Pages 583-589 Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. van Ramshorst J, Beeres SL, Rodrigo SF, Dibbets-Schneider P, Scholte AJ, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE

Intramyocardial bone marrow cell injection has been associated with improvements in myocardial perfusion and left ventricular function. The current substudy of a randomized, placebo-controlled, double-blinded study, investigated the effect of intramyocardial bone marrow cell injection on myocardial sympathetic innervation in patients with chronic myocardial ischemia. In a total of 16 patients (64 ± 8 years, 13 men), early and late iodine-123 metaiodobenzylguanidine (MIBG) imaging was performed b... Abstract

Cited 92 times since 2014 (8.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 63, Issue 12, 30 5 2014, Pages 1200-1210 Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Lubitz SA, Lunetta KL, Lin H, Arking DE, Trompet S, Li G, Krijthe BP, Chasman DI, Barnard J, Kleber ME, Dörr M, Ozaki K, Smith AV, Müller-Nurasyid M, Walter S, Agarwal SK, Bis JC, Brody JA, Chen LY, Everett BM, Ford I, Franco OH, Harris TB, Hofman A, Kääb S, Mahida S, Kathiresan S, Kubo M, Launer LJ, MacFarlane PW, Magnani JW, McKnight B, McManus DD, Peters A, Psaty BM, Rose LM, Rotter JI, Silbernagel G, Smith JD, Sotoodehnia N, Stott DJ, Taylor KD, Tomaschitz A, Tsunoda T, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Murabito JM, Sinner MF, Gudnason V, Felix SB, März W, Chung M, Albert CM, Stricker BH, Tanaka T, Heckbert SR, Jukema JW, Alonso A, Benjamin EJ, Ellinor PT

Objectives: This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk. Background: AF-associated loci span broad genomic regions that may contain multiple susceptibility signals. Whether multiple signals exist at AF loci has not been systematically explored. Methods: We performed association testing conditioned on the most significant, independently associated genetic markers at 9 established AF loci usi... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Journal of virology, Volume 88, Issue 8, 29 5 2014, Pages 4595-4599 Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models. Siegers JY, Short KR, Leijten LM, de Graaf M, Spronken MI, Schrauwen EJ, Marshall N, Lowen AC, Gabriel G, Osterhaus AD, Kuiken T, van Riel D

We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza. Abstract