Research

Publications

Below you can find a list of our published research.

6125 results

Annals of cardiothoracic surgery, Volume 12, Issue 3, 8 2 2023, Pages 244-252 Three decades of reimplantation of the aortic valve-the Brussels experience. Jahanyar J, de Kerchove L, Arabkhani B, Tsai PI, Aphram G, Mastrobuoni S, El Khoury G

Background: Over the last three decades, the importance of native valve preservation has increasingly become evident. Valve-sparing root replacement procedures, such as the reimplantation or remodeling technique, are therefore being progressively used for aortic root replacement and/or aortic valve repair. Herein, we are summarizing our single-center experience with the reimplantation technique. Methods: We queried our prospective database for aortic valve repair and recruited all adult (≥18 yea... Abstract

The American journal of cardiology, Volume 197, 2 1 2023, Pages 34-41 Risk Factors for Short-Term Versus Long-Term Mortality in Patients Who Underwent Cardiac Resynchronization Therapy. Galloo X, Khidir M, Stassen J, Hirasawa K, Cosyns B, van der Bijl P, Delgado V, Ajmone Marsan N, Bax JJ

Cardiac resynchronization therapy (CRT) is an effective therapy in selected patients with advanced heart failure that reduces all-cause mortality at short-term follow-up. However, data regarding long-term mortality after CRT implantation are scarce, with no separate analysis available of the covariates associated with respectively short-term and long-term outcomes. Accordingly, the present study evaluated the risk factors associated with short-term (2-year follow-up) versus long-term (10-year fo... Abstract

JACC. Cardiovascular interventions, Volume 16, Issue 10, 1 1 2023, Pages 1160-1172 Ventricular Remodeling and Outcomes After Mitral Transcatheter Edge-to-Edge Repair in Heart Failure: The COAPT Trial. Lindman BR, Asch FM, Grayburn PA, Mack MJ, Bax JJ, Gonzales H, Goel K, Barker CM, Zalawadiya SK, Zhou Z, Alu MC, Weissman NJ, Abraham WT, Lindenfeld J, Stone GW

Background: The relationship between left ventricular (LV) remodeling and clinical outcomes after treatment of severe mitral regurgitation (MR) in heart failure (HF) has not been examined. Objectives: The aim of this study was to evaluate the association between LV reverse remodeling and subsequent outcomes and assess whether transcatheter edge-to-edge repair (TEER) and residual MR are associated with LV remodeling in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Th... Abstract

Cited 8 times since 2023 (4.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 81, Issue 20, 1 1 2023, Pages 1979-1991 Hemodynamic Assessment in Takotsubo Syndrome. Stiermaier T, Reil JC, Sequeira V, Rawish E, Mezger M, Pätz T, Paitazoglou C, Schmidt T, Frerker C, Steendijk P, Reil GH, Eitel I

Background: Takotsubo syndrome (TTS) is a reversible form of heart failure with incompletely understood pathophysiology. Objectives: This study analyzed altered cardiac hemodynamics during TTS to elucidate underlying disease mechanisms. Methods: Left ventricular (LV) pressure-volume loops were recorded in 24 consecutive patients with TTS and a control population of 20 participants without cardiovascular diseases. Results: TTS was associated with impaired LV contractility (end-systolic elastance... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Annals of cardiothoracic surgery, Volume 12, Issue 3, 1 1 2023, Pages 149-158 Valve-sparing aortic root replacement using the reimplantation (David) technique: a systematic review and meta-analysis on survival and clinical outcome. Mastrobuoni S, Govers PJ, Veen KM, Jahanyar J, van Saane S, Segreto A, Zanella L, de Kerchove L, Takkenberg JJM, Arabkhani B

Background: Current guidelines recommend valve-sparing aortic root replacement (VSRR) procedures over valve replacement for the treatment of root aneurysm. The reimplantation technique seems to be the most widely used valve-sparing technique, with excellent outcomes in mostly single-center studies. The aim of this systematic review and meta-analysis is to present a comprehensive overview of clinical outcomes after VSRR with the reimplantation technique, and potential differences for bicuspid aor... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Human molecular genetics, Volume 32, Issue 10, 1 1 2023, Pages 1741-1752 Normal range CAG repeat size variations in the HTT gene are associated with an adverse lipoprotein profile partially mediated by body mass index. Faquih TO, Aziz NA, Gardiner SL, Li-Gao R, de Mutsert R, Milaneschi Y, Trompet S, Jukema JW, Rosendaal FR, van Hylckama Vlieg A, van Dijk KW, Mook-Kanamori DO

Tandem cytosine-adenine-guanine (CAG) repeat sizes of 36 or more in the huntingtin gene (HTT) cause Huntington's disease (HD). Apart from neuropsychiatric complications, the disease is also accompanied by metabolic dysregulation and weight loss, which contribute to a progressive functional decline. Recent studies also reported an association between repeats below the pathogenic threshold ( Abstract

Cited 9 times since 2023 (4.9 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 6, 1 1 2023, Pages 733-741 Prognostic implications of atrial vs. ventricular functional tricuspid regurgitation. Galloo X, Dietz MF, Fortuni F, Prihadi EA, Cosyns B, Delgado V, Bax JJ, Ajmone Marsan N

Aims: Atrial functional tricuspid regurgitation (AFTR) has shown distinctive pathophysiological and anatomical differences compared with ventricular functional tricuspid regurgitation (VFTR) with potential implications for interventions. However, little is known about the difference in long-term prognosis between these two FTR-aetiologies, which was investigated in the current study. Methods and results: Patients with severe FTR were divided into two aetiologies, based on echocardiography: AFTR... Abstract

Cited 2 times since 2023 (1.1 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 24, Issue 6, 1 1 2023, Pages 776-784 Importance of plaque volume and composition for the prediction of myocardial ischaemia using sequential coronary computed tomography angiography/positron emission tomography imaging. Wang X, van den Hoogen IJ, Butcher SC, Kuneman JH, de Graaf MA, Kamperidis V, Boukes M, Maaniitty T, Schultz J, van Rosendael AR, Saraste A, Knuuti J, Bax JJ

Aims: Coronary atherosclerosis with a large necrotic core has been postulated to reduce the vasodilatory capacity of vascular tissue. In the present analysis, we explored whether total plaque volume and necrotic core volume on coronary computed tomography angiography (CCTA) are independently associated with myocardial ischaemia on positron emission tomography (PET). Methods and results: From a registry of symptomatic patients with suspected coronary artery disease and clinically indicated CCTA w... Abstract

Transfusion, Volume 63 Suppl 3, 1 1 2023, Pages S249-S255 Screening for Zika virus in US armed services blood program donors: An opportunity to compare emerging infectious disease risk between the general US population and military donors. Fedyk CG, Shahin GM, Hill R, Cap AP, DoD Zika IND Investigators

Background: The U.S. Department of Defense (DoD) collects blood from volunteer DoD donors in U.S. Food and Drug Administration (FDA)-regulated centers, and from emergency donor panels in overseas operations. Emerging infectious diseases could reduce DoD access to blood products. In August 2016, FDA determined that Zika virus was transfusion-transmitted and advised that donated blood should be screened for Zika utilizing one of two investigational new drug (IND) applications. The Armed Services B... Abstract

Cited 2 times since 2023 (1.1 per year) source: EuropePMC

Cardiovascular research, Volume 119, Issue 4, 1 1 2023, Pages 998-1007 Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study. Luo J, Noordam R, Jukema JW, van Dijk KW, Hägg S, Grassmann F, le Cessie S, van Heemst D

Aim: Mitochondrial DNA dysfunction has been implicated in the pathogenesis of cardiovascular diseases. We aimed to investigate the associations between leukocyte mitochondrial DNA (mtDNA) abundance, as a proxy of mitochondrial function, and coronary artery disease (CAD) and heart failure (HF) in a cohort study and approximate the causal nature of these relationships using Mendelian randomization (MR) in genetic studies. Methods and results: Multivariable-adjusted Cox regression analyses were con... Abstract

Cited 26 times since 2023 (14.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 25, Issue 5, 1 1 2023, Pages euad091 Spotlight on the 2022 ESC guideline management of ventricular arrhythmias and prevention of sudden cardiac death: 10 novel key aspects. Könemann H, Dagres N, Merino JL, Sticherling C, Zeppenfeld K, Zeppenfeld K, Tfelt-Hansen J, Eckardt L

Sudden cardiac death and ventricular arrhythmias are a global health issue. Recently, a new guideline for the management of ventricular arrhythmias and prevention of sudden cardiac death has been published by the European Society of Cardiology that serves as an update to the 2015 guideline on this topic. This review focuses on 10 novel key aspects of the current guideline: As new aspects, public basic life support and access to defibrillators are guideline topics. Recommendations for the diagnos... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 5, 1 1 2023, Pages ezad029 Outcomes of the modified Yacoub aortocoronary flap technique for 'non-separable' single sinus coronary arteries with intramural course in the neonatal arterial switch operation. Van den Eynde J, van der Palen RLF, Knobbe I, Straver B, Stöger L, Ricciardi G, Konings TC, Jongbloed MRM, Hazekamp MG

Objectives: Coronary transfer remains the most crucial part of the arterial switch operation (ASO); yet, certain coronary anatomies prohibit the use of button or trap-door transfer techniques. In the rare setting of 'non-separable' single sinus coronary arteries with intramural course, the modified Yacoub aortocoronary flap technique is a viable option. The aim of this study is to describe this operative technique and review its early- and mid-term outcomes. Methods: This retrospective... Abstract

Photodiagnosis and photodynamic therapy, Volume 42, 27 4 2023, Pages 103582 Ocular perfusion characteristics of children with newly diagnosed epilepsy. Nalcacioglu P, Icoz M, Gultutan P, Yilmaz D, Citak Kurt AN

Background: To investigate the vascular changes of the optic nerve head (ONH) and macula by using optical coherence tomography angiography (OCT-A), and also the choroidal vascular structure by using an image binarization tool in children with newly diagnosed epilepsy and to then compare these parameters with healthy subjects. Methods: Forty-one epilepsy children and 36 healthy controls were included in this prospective and cross-sectional study.The radial peripapillary capillary (RPC) vessel den... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Frontiers in pharmacology, Volume 14, 27 4 2023, Pages 1098184 Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy. Buijsers B, Garsen M, de Graaf M, Bakker-van Bebber M, Guo C, Li X, van der Vlag J

Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases. A possible HPSE1 inhibitor is heparanase-2 (HPSE2) because HPSE2 is a structural homolog of HPSE1 without enzymatic activity. The importance of HPSE2 has been recently demonstrated in HPSE2-deficient mice, since these m... Abstract

Internet interventions, Volume 32, 27 4 2023, Pages 100626 Corrigendum to 'Put your money where your feet are: The real-world effects of StepBet gamified deposit contracts for physical activity' [Internet Interv., volume 31, March 2023, 100610]. de Buisonjé DR, Brosig F, Breeman LD, Bloom EL, Reijnders T, Janssen VR, Kraaijenhagen RA, Kemps HMC, Evers AWM

[This corrects the article DOI: 10.1016/j.invent.2023.100610.]. Abstract

Frontiers in cardiovascular medicine, Volume 10, 26 4 2023, Pages 1094969 Microinvasive mitral valve surgery: Current status and status quo. Tomšič A, Klautz RJM, Borger MA, Palmen M

Surgical mitral valve repair, performed either through median sternotomy or minimal invasive approach, presents the gold standard treatment for degenerative mitral valve disease. In dedicated centres, high repair and low complication rates have been established with excellent valve repair durability. Recently, new techniques have been introduced, that allow mitral valve repair to be performed through small surgical incisions and while avoiding cardio-pulmonary bypass. These new techniques, howev... Abstract

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

The Canadian journal of cardiology, Volume 39, Issue 10, 26 4 2023, Pages 1315-1324 Lipoprotein(a) and the Effect of Alirocumab on Revascularization After Acute Coronary Syndrome. Steg PG, Szarek M, Valgimigli M, Islam S, Zeiher AM, Bhatt DL, Bittner VA, Chiang CE, Diaz R, Goodman SG, Gotcheva N, Harrington RA, Jukema JW, Kim HS, Kim SH, Morais J, Pordy R, Scemama M, White HD, Schwartz GG, ODYSSEY OUTCOMES Investigators

Background: Many patients require revascularization after index acute coronary syndrome (ACS). Lipoprotein(a) is thought to play a pathogenic role in atherothrombosis. In ODYSSEY OUTCOMES, alirocumab reduced major adverse cardiovascular events after ACS, with greater reduction among those with higher lipoprotein(a) levels. We explored whether risk of revascularization after ACS was modified by the level of lipoprotein(a) and treatment with alirocumab or placebo. Methods: In ODYSSEY OUTCOMES alir... Abstract

Terapevticheskii arkhiv, Volume 95, Issue 3, 26 4 2023, Pages 248-254 [Difficult case of differential diagnosis of partial lung atelectasis. Case report]. Gordeeva OM, Egorova AD, Chesalina YO, Gretcov EM, Semenova LA, Karpina NL, Sivokozov IV

In December 2018 the patient over 60 years old sought medical help with complaints of persistent cough. Based on computed tomography data there were identified the sings (symptoms) of right lung lower lobe atelectasis. To run this patient diagnostics there were performed 6 bronchoscopies narrowed down by bronchi checks up only and described the right lung central cancer picture. At the same time the biopsy taken during one of the bronchoscopies appeared non informative. Fine needle biopsy of med... Abstract

Cited 6 times since 2023 (3.3 per year) source: EuropePMC

International journal of molecular sciences, Volume 24, Issue 9, 25 4 2023, Pages 7818 Atorvastatin Attenuates Diet-Induced Non-Alcoholic Steatohepatitis in APOE*3-Leiden Mice by Reducing Hepatic Inflammation. Inia JA, Stokman G, Pieterman EJ, Morrison MC, Menke AL, Verschuren L, Caspers MPM, Giera M, Jukema JW, van den Hoek AM, Princen HMG

Patients with metabolic syndrome are often prescribed statins to prevent the development of cardiovascular disease. Conversely, data on their effects on non-alcoholic steatohepatitis (NASH) are lacking. We evaluated these effects by feeding APOE*3-Leiden mice a Western-type diet (WTD) with or without atorvastatin to induce NASH and hepatic fibrosis. Besides the well-known plasma cholesterol lowering (-30%) and anti-atherogenic effects (severe lesion size -48%), atorvastatin significantly reduced... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

The Science of the total environment, Volume 883, 25 4 2023, Pages 163599 Capturing the SARS-CoV-2 infection pyramid within the municipality of Rotterdam using longitudinal sewage surveillance. de Graaf M, Langeveld J, Post J, Carrizosa C, Franz E, Izquierdo-Lara RW, Elsinga G, Heijnen L, Been F, van Beek J, Schilperoort R, Vriend R, Fanoy E, de Schepper EIT, Koopmans MPG, Medema G

Despite high vaccination rates in the Netherlands, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate. Longitudinal sewage surveillance was implemented along with the notification of cases as two parts of the surveillance pyramid to validate the use of sewage for surveillance, as an early warning tool, and to measure the effect of interventions. Sewage samples were collected from nine neighborhoods between September 2020 and November 2021. Comparative analysis an... Abstract