9543 results
Cited 4 times since 2024 (3.8 per year)
source: EuropePMC
JACC. Basic to translational science,
Volume 10, Issue 3, 30 5 2024, Pages 383-395
EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction.
Reilly NA, Dekkers KF, Molenaar J, Arumugam S, Kuipers TB, Ariyurek Y, Hoeksema MA, Jukema JW, Heijmans BT
Twice-daily intake of purified eicosapentaenoic acid (EPA) reduces atherosclerotic cardiovascular disease risk in patients with high triglycerides, but its exact mechanism remains unclear. We exposed non-activated CD4+ T cells to 100μM EPA, oleic acid, palmitic acid, or control, and conducted RNA and ATAC-sequencing after 48 hours. EPA exposure downregulated immune response-related genes like HLA-DRA, CD69, and IL2RA, and upregulated oxidative stress prevention genes like NQO1. Transcription fac...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Scientific reports,
Volume 14, Issue 1, 29 5 2024, Pages 26018
Accessible viral metagenomics for public health and clinical domains with Jovian.
Schmitz D, Zwagemaker F, Nooij S, Janssens TKS, Cremer J, Verhagen R, Vennema H, Kroneman A, Koopmans MPG, Laros JFJ, de Graaf M
The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality as...
Abstract
Cited 26 times since 2024 (24.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 9, 28 4 2024, Pages 878-890
Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD.
Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, Hahn RT, Popma A, Ben-Yehuda O, Kallel F, Redfors B, Chuang ML, Alu MC, Lindeboom W, Kolte D, Zahr FE, Kodali SK, Strote JA, Hermanides RS, Cohen DJ, Tijssen JGP, Leon MB
Background: Neurohormonal modulation and afterload reduction are key for treatment of heart failure with reduced ejection fraction (HFrEF). In HFrEF patients with concomitant moderate aortic stenosis (AS), treatment with transcatheter aortic valve replacement (TAVR) may be complementary to guideline-directed medical therapy (GDMT). Objectives: This study sought to determine whether TAVR for moderate AS provides clinical benefit in patients with HFrEF on top of GDMT. Methods: We performed an inve...
Abstract
Translational lung cancer research,
Volume 13, Issue 10, 28 4 2024, Pages 2813-2827
What do we know about the role of neoadjuvant targeted therapy in early-stage <i>EGFR</i>-mutant and <i>ALK</i>-fused non-small cell lung cancer?-a narrative review of the current literature.
Kemper M, Elges S, Kies P, Wiebe K, Lenz G, Bleckmann A, Evers G
Background and objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable EGFR-mutant and ALK-fused NSCLC re...
Abstract
Bladder cancer (Amsterdam, Netherlands),
Volume 10, Issue 3, 23 4 2024, Pages 215-220
Lifestyle Advice to Patients with Bladder Cancer: A National Survey of Dutch Urologists.
Beeren I, Koops C, van der Heijden AG, Aben KKH, Kiemeney LALM, Witjes JA, Vrieling A
Background: Not much is known about the extent to which urologists discuss lifestyle with patients with bladder cancer (BC), despite patients considering urologists as an important source of information and motivation. Objective: To determine how often lifestyle is asked about, advised on, and referred for by Dutch urologists to patients with BC, as well as to evaluate urologists' perceptions and barriers. Methods: An anonymous online survey was sent to Dutch urologists. The survey included...
Abstract
Cited 5 times since 2024 (4.6 per year)
source: EuropePMC
GeroScience,
Volume 47, Issue 2, 22 4 2024, Pages 2035-2045
Increased <sup>1</sup>H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease.
Zonneveld MH, Al Kuhaili N, Mooijaart SP, Slagboom PE, Jukema JW, Noordam R, Trompet S
The 1-HMR metabolomics-based MetaboHealth score, comprised of 14 serum metabolic markers, associates with disease-specific mortality, but it is unclear whether the score also reflects cognitive changes and functional impairment. We aimed to assess the associations between the MetaboHealth score with cognitive function and functional decline in older adults at increased cardiovascular risk. A total of 5292 older adults free of dementia at baseline with mean age 75.3 years (SD = 3.4) from the Pros...
Abstract
British journal of pharmacology,
Volume 182, Issue 18, 17 3 2024, Pages 4221-4235
Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis.
Woudenberg T, van der Bent ML, Kremer V, Waas ISE, Daemen MJAP, Boon RA, Quax PHA, Nossent AY
Background and purpose: Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability. We investigated the role of N6-methyladenosine (m6A), a common RNA modification, on endothelial integrity, focusing on the pro-atherogenic microRNA mi...
Abstract
Nature communications,
Volume 15, Issue 1, 17 3 2024, Pages 8953
Author Correction: Time-series sewage metagenomics distinguishes seasonal, human-derived and environmental microbial communities potentially allowing source-attributed surveillance.
Becsei Á, Fuschi A, Otani S, Kant R, Weinstein I, Alba P, Stéger J, Visontai D, Brinch C, de Graaf M, Schapendonk CME, Battisti A, De Cesare A, Oliveri C, Troja F, Sironen T, Vapalahti O, Pasquali F, Bányai K, Makó M, Pollner P, Merlotti A, Koopmans M, Csabai I, Remondini D, Aarestrup FM, Munk P
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Placenta,
Volume 158, 15 3 2024, Pages 105-112
First-trimester maternal tryptophan metabolites, utero-placental (vascular)development and hypertensive disorders of pregnancy: The Rotterdam periconceptional cohort.
van Zundert SKM, Broekhuizen M, Mirzaian M, van Rossem L, Danser AHJ, Willemsen SP, Griffioen PH, Koning AHJ, Mulders AGMGJ, van Schaik RHN, Steegers-Theunissen RPM
Background: Hypertensive disorders of pregnancy (HDP) are a significant cause of maternal and perinatal mortality and morbidity. Knowledge on the placenta-related pathophysiology of HDP is increasing. Since maternal tryptophan metabolites are involved in placentation, we investigated associations between first-trimester tryptophan metabolites and utero-placental (vascular) development, and the occurrence of HDP. Methods: 911 women were included from a prospective tertiary hospital cohort. Serum...
Abstract
Cureus,
Volume 16, Issue 10, 15 3 2024, Pages e71545
Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps?
Turhan N, Ertorul D, Duran C, Kılıç MG, Kuzan TY, Yaşar S, Yılmaz D, Zarbaliyev E
Background Data regarding the frequency of development of gallbladder pathologies in patients with colon polyps are quite limited and heterogeneous. Hence, this study aimed to investigate whether colon polyps cause an increased risk of developing gallbladder pathologies and the necessity of ultrasonographic screening. Methodology This retrospective, cross-sectional study was conducted among adult patients who underwent a colonoscopy and hepatobiliary ultrasound as part of their health check-up f...
Abstract
The Journal of antibiotics,
Volume 78, Issue 1, 15 3 2024, Pages 54-63
Exploration of vanoxerine analogues as antibacterial agents.
Kingdon ADH, Adcock HV, Kasimati EM, Craven P, van Schaik W, Cox LR, Besra GS
Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuberculosis infections. The complex treatment regimen required to treat tuberculosis and growing rates of drug resistance, necessitates the development of new anti-mycobacterial agents. One approach is to repurpose drugs from other clinical applications. Vanoxerine (GBR 12909) was previously shown to have anti-mycobacterial activity, through dissipating the membrane electric pote...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
JACC. Advances,
Volume 3, Issue 11, 14 2 2024, Pages 101327
30 Years' Experience in Percutaneous Pulmonary Artery Interventions in Transposition of the Great Arteries.
Joosen RS, van der Palen RLF, Udink Ten Cate FEA, Voskuil M, Krings GJ, Bökenkamp R, Molenschot MC, Hahurij ND, Dickinson MG, Hazekamp MG, Schoof PH, Slieker MG, Straver B, Blom NA, Breur JMPJ
Background: Pulmonary artery (PA) stenosis is common after arterial switch operation (ASO) for transposition of the great arteries (TGA). Differences between balloon angioplasty (BA) and stents on right ventricular (RV) and PA pressures are not well studied. Objectives: The purpose of this study was to analyze percutaneous PA interventions' frequency after ASO, complications, and the effects of BA and stents on RV and PA pressures. Methods: All TGA patients with ASO between 1977 and 2022 in...
Abstract
Cited 4 times since 2024 (3.6 per year)
source: EuropePMC
European journal of clinical investigation,
Volume 54, Issue 12, 13 2 2024, Pages e14317
Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry.
Stähli BE, Schindler M, Schweiger V, Cammann VL, Szawan KA, Niederseer D, Würdinger M, Schönberger A, Schönberger M, Koleva I, Mercier JC, Petkova V, Mayer S, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm
Background: The clinical relevance of cardiac troponin (cTn) elevation in takotsubo syndrome (TTS) remains uncertain. The present study sought to investigate the role of cardiac troponin (cTn) elevations in mortality prediction of patients with Takotsubo syndrome (TTS). Methods: Patients enrolled in the International Takotsubo (InterTAK) Registry from January 2011 to February 2020 with available data on peak cTn levels were included in the analysis. Peak cTn levels during the index hospitalizati...
Abstract
Cited 3 times since 2024 (2.7 per year)
source: EuropePMC
Advances in simulation (London, England),
Volume 9, Issue 1, 12 2 2024, Pages 43
Changing the conversation: impact of guidelines designed to optimize interprofessional facilitation of simulation-based team training.
Ju M, Bochatay N, Werne A, Essakow J, Tsang L, Nottingham M, Franzon D, Lyndon A, van Schaik S
Background: Interprofessional simulation-based team training (ISBTT) is commonly used to optimize interprofessional teamwork in healthcare. The literature documents the benefits of ISBTT, yet effective interprofessional collaboration continues to be challenged by complex hierarchies and power dynamics. Explicitly addressing these issues during ISBTT may help participants acquire skills to navigate such challenges, but guidelines on how to do this are limited. Methods: We applied an educational d...
Abstract
Cited 4 times since 2024 (3.6 per year)
source: EuropePMC
EBioMedicine,
Volume 109, 12 2 2024, Pages 105391
Patterns of the within-host evolution of human norovirus in immunocompromised individuals and implications for treatment.
Izquierdo-Lara RW, Villabruna N, Hesselink DA, Schapendonk CME, Ribó Pons S, Nieuwenhuijse D, Meier JIJ, Goodfellow I, Dalm VASH, Fraaij PLA, van Kampen JJA, Koopmans MPG, de Graaf M
Background: Currently, there is no licensed treatment for chronic norovirus infections, but the use of intra-duodenally-delivered immunoglobulins is promising; nevertheless, varying results have limited their wide use. Little is known about the relationship between norovirus genetic diversity and treatment efficacy. Methods: We analyzed the norovirus within-host diversity and evolution in a cohort of 20 immunocompromised individuals using next-generation sequencing (NGS) and clone-based sequenci...
Abstract
BMC anesthesiology,
Volume 24, Issue 1, 9 2 2024, Pages 362
The effect of three different nonpharmacological methods on cannulation success during peripheral intravenous catheter placement in the emergency unit: a randomized controlled trial.
Yılmaz E, Yılmaz D
Background: Peripheral intravenous catheterization is frequently performed in emergency units, but it is a procedure which is difficult for healthcare professionals and painful for patients. The primary objective of the present study was to examine the effect on venous dilation, procedure duration and pain severity of local heat, cold and vibration applications performed on the intervention area before peripheral intravenous catheterization in adults. The second objective of the study was to exa...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 11, Issue 10, 7 1 2024, Pages 310
Association between Left Atrial Function and Survival in Systemic Sclerosis.
Giucă A, Galloo X, Meucci MC, Butcher SC, Popescu BA, Jurcuț R, Săftoiu A, Jurcuț C, Groșeanu L, Mușetescu AE, Ahmed S, De Vries-Bouwstra J, Bax JJ, Ajmone Marsan N
Systemic sclerosis (SSc) is a multisystemic autoimmune disorder in which cardiac involvement is frequent and portends negative prognosis. Left ventricular (LV) diastolic dysfunction is one of the most common cardiac alterations in these patients, and left atrial (LA) reservoir strain (ƐR) measurement using speckle tracking echocardiography has been proposed as a novel parameter for a better assessment of LV diastolic function. Therefore, the aim of this study was to test the prognostic value of...
Abstract
Biosensors & bioelectronics,
Volume 267, 5 1 2024, Pages 116838
μREACT: A microfluidic system for rapid evaluation of trans-kingdom interactions.
Huang C, Yang J, Chen S, Han SI, Zhang H, Samuel J, Van Schaik E, de Figueiredo P, Han A
Trans-kingdom interactions between cells play pivotal roles in shaping intricate ecological and biological networks. However, our grasp of these interactions remains incomplete. Specifically, the vast phylogenetic spectrum of microorganisms capable of interacting with a given host cell type remains obscure, primarily due to the absence of efficient, high-throughput, single-cell resolution systems that can rapidly decipher these interactions. Here, we introduce μREACT (Microfluidic system for Rap...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Journal of dairy science,
Volume 108, Issue 1, 5 1 2024, Pages 821-834
Risk factors for the introduction of bovine viral diarrhea virus in the context of a mandatory control program in Dutch dairy herds.
Bisschop PIH, Strous EEC, Waldeck HWF, van Duijn L, Mars MH, Santman-Berends IMGA, Wever P, van Schaik G
Bovine viral diarrhea virus (BVDV) is a common viral disease in cattle, causing economic losses in naive herds where the virus is introduced. In the Netherlands, a BVDV control program has been in place from 1998 onward, evolving from voluntary to mandatory participation for dairy herds from April 2018 onward. Participation in the BVDV control program is not mandatory for nondairy farms. The aim of this study was to determine risk factors for new introduction of BVDV into certified BVDV-free her...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Veterinaria italiana,
Volume 60, Issue 1, 4 1 2024
Using scenario tree modelling to evaluate the probability of freedom from Enzootic bovine leukosis (EBL) in Italy and Slovenia.
Fanelli A, Baron J, Comin A, Faverjon C, Feliziani F, Guelbenzu-Gonzalo M, Hodnik J, Iscaro C, Knific T, Meletis E, Mincu M, Righi C, Thomas R, Tamba M, Frössling J, Van Schaik G
Documented freedom from disease is paramount for international free trade of animals and animal products. This study describes a scenario tree analysis to estimate the probability of freedom from Enzootic bovine leukosis (EBL) in Italy and Slovenia using information gathered via the data collection tool developed in the COST action project SOUND-control. Data on EBL control programmes (CPs) from 2018 to 2021 were used to build the models. Since animals are only sampled on the farm, one surveilla...
Abstract
