9543 results
Cited 7 times since 2024 (6.2 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 35, Issue 1, 3 1 2024, Pages 1-11
The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation.
Cavallari LH, Hicks JK, Patel JN, Elchynski AL, Smith DM, Bargal SA, Fleck A, Aquilante CL, Killam SR, Lemke L, Ochi T, Ramsey LB, Haidar CE, Ho T, El Rouby N, Monte AA, Allen JD, Beitelshees AL, Bishop JR, Bousman C, Campbell R, Cicali EJ, Cook KJ, Duong B, Tsermpini EE, Girdwood ST, Gregornik DB, Grimsrud KN, Lamb N, Lee JC, Lopez RO, Mazhindu TA, Morris SA, Nagy M, Nguyen J, Pasternak AL, Petry N, van Schaik RHN, Schultz A, Skaar TC, Al Alshaykh H, Stevenson JM, Stone RM, Tran NK, Tuteja S, Woodahl EL, Yuan LC, Lee CR
Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations with drug response, pharmacogenetic testing has not been widely implemented into clinical practice. Among the barriers to broad implementation are limited guidance for how to successfully integrate testing into clinical workflows and limited...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Infection and immunity,
Volume 92, Issue 11, 2 1 2024, Pages e0033524
Molecular mechanisms of <i>Coxiella burnetii</i> formalin-fixed cellular vaccine reactogenicity.
Fratzke AP, Szule JA, Butler SM, Schaik EJv, Samuel JE
Local and systemic reactogenic responses to Q-VAX have prevented licensing of this vaccine outside of Australia. These reactogenic responses occur in previously sensitized individuals and have not been well defined at the cellular level, in part because many studies have been done in guinea pigs that have limited molecular tools. We previously characterized a mouse model of reactogenicity where local reaction sites showed an influx of CD8+ and IFNγ-expressing IL17a+ CD4+ T cells consistent with...
Abstract
NPJ precision oncology,
Volume 8, Issue 1, 2 1 2024, Pages 220
A phenocopy signature of TP53 loss predicts response to chemotherapy.
Bakhtiar H, Sharifi MN, Helzer KT, Shi Y, Bootsma ML, Shang TA, Chrostek MR, Berg TJ, Carson Callahan S, Carreno V, Blitzer GC, West MT, O'Regan RM, Wisinski KB, Sjöström M, Zhao SG
In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with neoadjuvant chemotherapy, the TP53-loss phenocopy samples were 56% more likely to have a pathologic...
Abstract
Cited 13 times since 2024 (11.4 per year)
source: EuropePMC
Journal of vascular surgery. Venous and lymphatic disorders,
Volume 13, Issue 1, 2 1 2024, Pages 101970
Nutcracker syndrome (a Delphi consensus).
Heilijgers F, Gloviczki P, O'Sullivan G, Chavent B, Avgerinos ED, Harth K, Black SA, Erben YM, Rotmans JI, Richards T, Chaer RA, Villalba L, Jayaraj A, Malgor RD, Tripathi RK, Dua A, Murphy E, Rinckenbach S, Vedantham S, Hamming JF, van der Vorst JR
Background: Nutcracker syndrome (NCS) describes the symptomatic compression of the left renal vein between the aorta and superior mesenteric artery. Whereas asymptomatic compression is a common radiological finding, patients with NCS can report a range of symptoms. There are no specific diagnostic criteria and interventions include a range of open surgical and endovascular procedures. Therefore, we wished to develop an international consensus document covering aspects of diagnosis, management, a...
Abstract
Cited 5 times since 2024 (4.4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 26, Issue 10, 1 1 2024, Pages euae235
Ventricular arrhythmias in acute heart failure: a clinical consensus statement of the Association for Acute CardioVascular Care, the European Heart Rhythm Association, and the Heart Failure Association of the European Society of Cardiology.
Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O
Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher intra-hospital and 60-day morbidity and mortality. Risk strati...
Abstract
JACC. Cardiovascular interventions,
Volume 17, Issue 20, 1 1 2024, Pages 2408-2410
The Promise and Challenges of Pressure-Guided Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension.
Montero-Cabezas JM, Delgado V
Abstract
Giornale italiano di cardiologia (2006),
Volume 25, Issue 10, 1 1 2024, Pages 699-710
[Ten questions about infective endocarditis].
Fortuni F, Ciliberti G, Marsan NA, Delgado V, Franchin L, Magnesa M, Spinelli A, Vitale E, Cangemi S, Cornara S, Gabrielli D, Colivicchi F, Grimaldi M, Oliva F
Infective endocarditis (IE) is an infective process involving the endocardium and, more frequently, the native heart valves, valvular prostheses and cardiac implantable electronic devices. IE can manifest with various non-specific symptoms making the diagnosis challenging. This condition is associated with high in-hospital and long-term mortality. Therefore, it is particularly important to prevent it by implementing an adequate antibiotic prophylaxis especially in patients at high risk undergoin...
Abstract
Cited 3 times since 2024 (2.6 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 38, Issue 20, 1 1 2024, Pages e70087
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice.
Inia JA, Attema J, de Ruiter C, Menke AL, Caspers MPM, Verschuren L, Wilson M, Arlantico A, Brightbill HD, Jukema JW, van den Hoek AM, Princen HMG, Chen MZ, Morrison MC
Fibroblast growth factor 21 (FGF21) is a promising target for treatment of obesity-associated diseases including metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. We evaluated the effects of the bispecific anti-FGF21-β klotho (KLB) agonist antibody bFKB1 in a preclinical model of MASH and atherosclerosis. Low-density lipoprotein receptor knockout (Ldlr-/-).Leiden mice received a high-fat diet for 20 weeks, followed by treatment with an isotype control antibody or bFKB1...
Abstract
Journal of cardiothoracic surgery,
Volume 19, Issue 1, 1 1 2024, Pages 560
Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates.
Dolmaci OB, van Maasakker NE, Poelmann RE, Klautz RJ, Grewal N
Background: Patients with a bicuspid aortic valve carry an increased risk for developing an ascending aortic aneurysm due to intrinsic aortic wall alterations. A lower threshold for aortic surgery may therefore be considered in these patients, especially in those who require aortic valve surgery. This study aimed to compare the outcomes of an isolated aortic valve replacement with that of an aortic root replacement in bicuspid aortic valve patients with an indication for aortic valve surgery. Me...
Abstract
Cited 3 times since 2024 (2.6 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 66, Issue 4, 1 1 2024, Pages ezae339
European Association of Cardiothoracic Surgeons future view on robotic cardiac surgery in Europe.
Oosterlinck W, Gianoli M, Palmen M, Folliguet T, Bonatti J, Agnino A, Singh S, Franke U, Modi P, Pereda D, Kempfert J, Navarra E, Suwalski P, Vojacek J, Casselman F, Myers P, Sadaba JR, Melfi F, Hazekamp M, Bavaria J, Beyersdorf F, Milojevic M, Falk V, Cerny S
Abstract
Cited 12 times since 2024 (10.5 per year)
source: EuropePMC
Brain communications,
Volume 6, Issue 5, 1 1 2024, Pages fcae309
Sudden death in epilepsy: the overlap between cardiac and neurological factors.
Shlobin NA, Thijs RD, Benditt DG, Zeppenfeld K, Sander JW
People with epilepsy are at risk of premature death, of which sudden unexpected death in epilepsy (SUDEP), sudden cardiac death (SCD) and sudden arrhythmic death syndrome (SADS) are the primary, partly overlapping, clinical scenarios. We discuss the epidemiologies, risk factors and pathophysiological mechanisms for these sudden death events. We reviewed the existing evidence on sudden death in epilepsy. Classification of sudden death depends on the presence of autopsy and expertise of the clinic...
Abstract
Cited 727 times since 2024 (636.5 per year)
source: EuropePMC
European heart journal,
Volume 45, Issue 38, 1 1 2024, Pages 3912-4018
2024 ESC Guidelines for the management of elevated blood pressure and hypertension.
McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, Christodorescu RM, Daskalopoulou SS, Ferro CJ, Gerdts E, Hanssen H, Harris J, Lauder L, McManus RJ, Molloy GJ, Rahimi K, Regitz-Zagrosek V, Rossi GP, Sandset EC, Scheenaerts B, Staessen JA, Uchmanowicz I, Volterrani M, Touyz RM, ESC Scientific Document Group
Abstract
Cited 90 times since 2024 (78.8 per year)
source: EuropePMC
European heart journal,
Volume 45, Issue 38, 1 1 2024, Pages 4063-4098
Obesity and cardiovascular disease: an ESC clinical consensus statement.
Koskinas KC, Van Craenenbroeck EM, Antoniades C, Blüher M, Gorter TM, Hanssen H, Marx N, McDonagh TA, Mingrone G, Rosengren A, Prescott EB, ESC Scientific Document Group
The global prevalence of obesity has more than doubled over the past four decades, currently affecting more than a billion individuals. Beyond its recognition as a high-risk condition that is causally linked to many chronic illnesses, obesity has been declared a disease per se that results in impaired quality of life and reduced life expectancy. Notably, two-thirds of obesity-related excess mortality is attributable to cardiovascular disease. Despite the increasingly appreciated link between obe...
Abstract
Cited 7 times since 2024 (6.1 per year)
source: EuropePMC
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Volume 29, Issue 40, 1 1 2024
Attribution of invasive group A streptococcal infections (iGAS) to predisposing viral infections, the Netherlands, 2010 to 2023.
de Gier B, van de Kassteele J, van Asten L, Schoffelen AF, ISIS-AR study group, Hooiveld M, Te Wierik MJ, van Sorge NM, de Melker HE, Members of the ISIS-AR study group
BackgroundAfter most COVID-19 pandemic control measures were lifted in 2022, many infectious diseases re-emerged. An increase in invasive group A streptococcal (iGAS) infections among adults and young children was reported by several countries. Viral infections including influenza and varicella, known risk factors for iGAS infection, also increased.AimTo estimate the proportion of GAS skin and soft tissue infections (SSTI) and pneumonia/sepsis in children (≤ 5 years) attributable to varicella, a...
Abstract
The Journal of antimicrobial chemotherapy,
Volume 79, Issue 10, 1 1 2024, Pages 2622-2632
Association between antimicrobial usage in livestock and antimicrobial resistance in Escherichia coli isolates from human urinary tract infections in the Netherlands, 2009-2020.
Meijs AP, Chanamé-Pinedo LE, Deng H, Veldman KT, Brouwer MSM, van den Beld MJC, Dierikx CM, Sanders P, Wullings B, de Greeff SC, van Duijkeren E, Franz E, Pijnacker R, Mughini-Gras L, ISIS-AR study group
Background: In the last decade, veterinary antimicrobial usage (AMU) and antimicrobial resistance (AMR) among indicator bacteria in livestock have decreased substantially in the Netherlands. The extent to which this decrease has affected AMR levels among human infections remains unclear. Objectives: To assess the association between AMU in livestock and AMR in Escherichia coli isolates from human urinary tract infections (UTIs). Methods: Data on AMR and AMU between 2009 and 2020 from Dutch natio...
Abstract
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir,
Volume 52, Issue 7, 1 1 2024, Pages 474-483
Baseline Characteristics and Clinical Insights from the ARTEMIS Registry: A Comprehensive Study of Peripartum Cardiomyopathy in Türkiye.
Kayıkçıoğlu M, Biteker M, Mutluer FO, Güzel T, Yılmaz E, Demir E, Nalbantgil S, Ertaş F, Çiçek Yılmaz D, Temizhan A, Aşkın L, Dinç Asarcıklı L, Akçay M, Demirbağ R, Köroğlu S, Örnek E, Çelik A, Akıl MA, Arslan B, Tokgözoğlu L, Artemis Investigators
Objective: Peripartum Cardiomyopathy (PPCM) is a life-threatening, rare disorder that occurs during the late stages of pregnancy or the early postpartum period. The ARTEMIS (A RegisTry of pEripartuM cardIomyopathy in Turkish patientS) aims to investigate the clinical characteristics and outcomes of PPCM in Türkiye, providing insights into its management within this specific population. Methods: The ARTEMIS registry retrospectively enrolled patients diagnosed with PPCM within the last five years...
Abstract
European heart journal. Imaging methods and practice,
Volume 2, Issue 4, 1 1 2024, Pages qyaf033
Factors affecting the performance of a novel artificial intelligence-based coronary computed tomography-derived ischaemia algorithm.
Kiatkittikul P, Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J
Aims: AI-QCTischaemia is an FDA-cleared novel artificial intelligence-guided method that utilizes features from coronary computed tomography angiography (CCTA) to predict myocardial ischaemia. Objective: To identify factors associated with discrepancy between AI-QCTischaemia and positron emission tomography (PET) perfusion. Methods and results: Six hundred and sixty-two patients with suspected obstructive coronary artery disease (CAD) on CCTA and undergoing [15O]H2O PET were analysed using AI-QC...
Abstract
Cited 10 times since 2024 (8.8 per year)
source: EuropePMC
JAMA dermatology,
Volume 160, Issue 10, 1 1 2024, Pages 1044-1055
Long-Term Effectiveness and Reasons for Discontinuation of Dupilumab in Patients With Atopic Dermatitis.
Boesjes CM, Kamphuis E, de Graaf M, Spekhorst LS, Haeck I, van der Gang LF, Loman L, Zuithoff NPA, Dekkers C, van der Rijst LP, Romeijn GLE, Oosting AJ, Gostynksi A, van Lynden-van Nes AMT, Tupker RA, van Tuyll van Serooskerken AM, Flinterman A, Politiek K, Touwslager WRH, Christoffers WA, Stewart SM, Kamsteeg M, Schuttelaar MA, de Bruin-Weller MS
Importance: Limited data are available on the long-term effectiveness and safety of dupilumab for atopic dermatitis (AD) in daily practice. Objective: To evaluate clinical effectiveness and reasons for discontinuation of dupilumab treatment in children, adults, and older adults with AD with up to 5 years of treatment in daily practice. Design, setting, and participants: This prospective multicenter cohort study was conducted using the BioDay registry (4 academic and 10 nonacademic hospitals in t...
Abstract
Cited 12 times since 2024 (10.5 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 31, Issue 14, 1 1 2024, Pages 1690-1699
Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.
Hageman SHJ, Kaptoge S, de Vries TI, Lu W, Kist JM, van Os HJA, Numans ME, Läll K, Bobak M, Pikhart H, Kubinova R, Malyutina S, Pająk A, Tamosiunas A, Erbel R, Stang A, Schmidt B, Schramm S, Bolton TR, Spackman S, Bakker SJL, Blaha M, Boer JMA, Bonnefond A, Brenner H, Brunner EJ, Cook NR, Davidson K, Dennison E, Donfrancesco C, Dörr M, Floyd JS, Ford I, Fu M, Gansevoort RT, Giampaoli S, Gillum RF, Gómez-de-la-Cámara A, Håheim LL, Hansson PO, Harms P, Humphries SE, Ikram MK, Jukema JW, Kavousi M, Kiechl S, Kucharska-Newton A, Pablos DL, Matsushita K, Meyer HE, Moons KGM, Mortensen MB, Muilwijk M, Nordestgaard BG, Packard C, Pamieri L, Panagiotakos D, Peters A, Potier L, Providencia R, Psaty BM, Ridker PM, Rodriguez B, Rosengren A, Sattar N, Schöttker B, Schwartz JE, Shea S, Shipley MJ, Sofat R, Thorand B, Verschuren WMM, Völzke H, Wareham NJ, Westbury L, Willeit P, Zhou B, Danesh J, Visseren FLJ, Di Angelantonio E, Pennells L, Dorresteijn JAN
Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals. Methods and results: The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual partici...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 41, Issue 10, 1 1 2024, Pages e70006
Evolution and Prognostic Impact of Left Ventricular Myocardial Work Indices After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
Wu HW, Fortuni F, Muzafarova T, Sarrazyn C, Lopez Santi P, Chua APA, Butcher SC, van der Kley F, de Weger A, Jukema JW, Bax JJ, Ajmone Marsan N
Purpose: Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and their prognostic value. Methods: The following LVMW indices were calculated before and immediately after TAVR in 255 patients (median age 82 years, 51% male): global work index (GWI), global constructive work...
Abstract
