Research

Publications

Below you can find a list of our published research.

6125 results

Cited 63 times since 1996 (2.2 per year) source: EuropePMC

Virology, Volume 220, Issue 2, 1 1 1996, Pages 367-376 Activation of oriLyt, the lytic origin of DNA replication of Epstein-Barr virus, by BZLF1. Schepers A, Pich D, Hammerschmidt W

oriLyt, the cis-acting element of the lytic origin of DNA replication of Epstein-Barr virus, is activated by the viral transactivator BZLF1 which belongs to the extended bZIP class of transcription factors. Seven binding sites for BZLF1, so-called ZRE sites, are located within oriLyt. By mutational analysis of individual ZRE sites, we found that lytic DNA replication is dependent on only four of these sites which colocate with the promoter of the BHLF1 gene. The remaining three ZRE sites distal... Abstract

Cited 1 times since 1996 (0 per year) source: EuropePMC

Medizinische Klinik (Munich, Germany : 1983), Volume 91, Issue 6, 1 1 1996, Pages 417-419 [Ticlopidine-induced pancytopenia: therapy of agranulocytosis with granulocyte colony stimulating factor]. Schneider AW, Fechler L, Gilfrich HJ

Abstract

Cited 4 times since 1996 (0.1 per year) source: EuropePMC

European journal of radiology, Volume 22, Issue 2, 1 1 1996, Pages 158-160 Percutaneous drainage of septic glenohumoral arthritis. de Witte MT, van Overhagen H, Hamming JF, Laméris JS

Abstract

Cited 35 times since 1996 (1.2 per year) source: EuropePMC

Surgical endoscopy, Volume 10, Issue 5, 1 1 1996, Pages 490-494 Laparoscopic surgery in the rat. Beneficial effect on body weight and tumor take. Bouvy ND, Marquet RL, Hamming JF, Jeekel J, Bonjer HJ

Background: The ability of laparoscopic techniques to treat malignant disease is controversial. We developed a rat model to assess metabolic and oncological effects of laparoscopic surgery. Methods: Experiment I. The postoperative body weight in 10 rats having laparoscopic bowel resection (group I), 10 rats having open bowel resection (group II) and 5 rats having anesthesia only (group III) was determined. Experiment II. Tumor take was scored in 11 rats having laparoscopic bowel resection (group... Abstract

Fortschritte der Medizin, Volume 114, Issue 8, 1 1 1996, Pages 91-98 [Reduction of cardiovascular events with pravastatin. A pooled analysis of clinical events within the scope of the Pravastatin Atherosclerosis Intervention Program]. Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV, Hoen H, Furberg CD, Mancini GB

Background: It has been documented that the HMG coenzyme A reductase inhibitors, or statins, can decrease cardiovascular events and mortality in patients with clinical coronary disease and moderately to severely elevated lipid levels. Additional data are required to demonstrate a reduction of vascular events in coronary patients with less than severely elevated lipid levels and in subgroups of this population. Methods and results: Clinical data from four atherosclerosis regression trials that ev... Abstract

Cited 61 times since 1996 (2.1 per year) source: EuropePMC

Diseases of the colon and rectum, Volume 39, Issue 3, 1 1 1996, Pages 323-328 Surgery for local recurrence of rectal carcinoma. Wiggers T, de Vries MR, Veeze-Kuypers B

Purpose: This study was designed to evaluate results, especially mortality and morbidity, of surgical resection with curative intent for patients with a local recurrence of rectal cancer, in combination with radiotherapy. Methods: Consecutive medical records of 163 patients with local recurrence of rectal carcinoma after previous "curative" therapy for primary rectal cancer were reviewed. Although 35 patients had an exploratory laparotomy, only 27 had local recurrence amendable to rese... Abstract

Cited 33 times since 1996 (1.1 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 16, Issue 3, 1 1 1996, Pages 425-430 Evidence for a synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis in symptomatic patients with normal to moderately raised cholesterol levels. The REGRESS Study Group. Jukema JW, Zwinderman AH, van Boven AJ, Reiber JH, Van der Laarse A, Lie KI, Bruschke AV

To date, lipid-lowering therapy appears to be the most effective medical intervention to retard progression of coronary atherosclerosis. In spite of promising experimental results, clinical trials completed so far have failed to demonstrate that calcium channel blockers (CCBs) alone influence the evolution of established coronary atherosclerosis. To assess whether the two therapies may have an additive or synergistic beneficial effect on human atherosclerosis, we reviewed in this regard the data... Abstract

Cited 2 times since 1996 (0.1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 61, Issue 3, 1 1 1996, Pages 1005-1006 Pulmonary autograft in ventricular septal defect-aortic insufficiency complex. Schoof PH, Hazekamp MG, Huysmans HA

Pulmonary autograft aortic root replacement in a child with the ventricular septal defect-aortic insufficiency complex is described. It offers all the advantages of the autograft, avoids closure of the ventricular septal defect, and prevents the use of prosthetic material. Abstract

Cited 16 times since 1996 (0.5 per year) source: EuropePMC

Magnetic resonance imaging, Volume 14, Issue 1, 1 1 1996, Pages 21-29 Assessment of acute myocardial infarction in man with magnetic resonance imaging and the use of a new paramagnetic contrast agent gadolinium-BOPTA. Holman ER, van Rossum AC, Doesburg T, van der Wall EE, de Roos A, Visser CA

To assess the feasibility of and characterize the new paramagnetic contrast agent gadolinium-BOPTA/dimeglumine (Gd-BOPTA) to detect acute myocardial infarctions with MR imaging, 24 patients (53.3 +/- 8.3 yr) were examined 9.3 +/- 3.6 days after a first myocardial infarction. Short-axis T1-weighted and T2-weighted MR imaging was performed at three slice levels. T1-weighted images were obtained before, immediately after, 15, 30, and 45 min after injection. Patients received either 0.05 or 0.1 mmol... Abstract

Cited 3 times since 1996 (0.1 per year) source: EuropePMC

European journal of applied physiology and occupational physiology, Volume 73, Issue 1-2, 1 1 1996, Pages 113-116 Intravenous instrumentation alters the autonomic state in humans. Bootsma M, Swenne CA, Lenders JW, Jacobs MC, Bruschke AV

Intravascular instrumentation may induce syncope or presyncope. It is not known whether asymptomatic subjects also have autonomic reactions, albeit concealed. We addressed this issue by studying 44 healthy young male subjects of various levels of fitness, ranging from inactivity to athletic [mean maximal oxygen uptake was 49.1 (SD 10.7) ml*kg(-1)*min(-1), range 28.7-71.9 ml*kg(-1)*min(-1)]. The autonomic response to venous cannulation was quantified by measuring heart rate before cannulation (HR... Abstract

Cited 9 times since 1996 (0.3 per year) source: EuropePMC

Clinical cardiology, Volume 19, Issue 1, 1 1 1996, Pages 62-68 Heart rate variability during repeated incremental head-up tilt discloses time dependence of individual autonomic dynamics. Bootsma M, Swenne CA, Bruschke AV

According to the Rosenblueth-Simeone model, the heart rate (HR) is proportional to the sympathovagal balance. The individual proportionality constant is the intrinsic HR, which can be determined only invasively. The percentage low-frequency spectral HR variability power, relative to the low- plus high-frequency spectral power (%LF) has been raised as a noninvasive alternative. We previously studied young healthy male subjects, in whom gradual autonomic changes were induced by incremental head-up... Abstract

Cited 7 times since 1996 (0.2 per year) source: EuropePMC

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, Volume 16 Suppl 1, 1 1 1996, Pages S362-7 Impaired initial cell reaction in CAPD-related peritonitis. Koopmans JG, Boeschoten EW, Pannekeet MM, Betjes MG, Zemel D, Kuijper EJ, Krediet RT

Our objective was to determine the incidence of peritonitis episodes with an impaired initial cell reaction (IICR:neutrophil number < 100 x 10(6)/L) over a period of ten years, and to find possible explanations for this unusual presentation of peritonitis. A retrospective review of the files of continuous ambulatory peritoneal dialysis (CAPD) patients included in the CAPD program 1984 and 1993 was done. Analysis of cytokine and prostanoid patterns during four peritonitis episodes with an IICR... Abstract

Journal of thrombosis and thrombolysis, Volume 3, Issue 3, 1 1 1996, Pages 215-223 Different Effects of Lipopolysaccharide on Plasminogen Activator Inhibitor-1 Production in Aortic Media in Vivo and in Culture. van Leeuwen RT, Quax PH, Tippins JR, Antoniw JW, Andreotti F, Maseri A, Kluft C, Sperti G

Background: Lipopolysaccharide (endotoxin) has been shown to increase the expression of plasminogen activator inhibitor type-1 (PAI-1) in the vessel wall. Endotoxin is known to increase PAI-1 production in endothelial cells, but its action on smooth muscle cells (SMCs) is presently not clear. In this study we determined the effect of endotoxin on PAI-1 and tissue plasminogen activator (t-PA) production by aortic SMCs in vivo in two animal species, and in culture. Methods: The aortas of Sprague D... Abstract

Cited 11 times since 1996 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 10, Issue 5, 1 1 1996, Pages 299-304 Upper and lower extremity somatosensory evoked potential recording during surgery for aneurysms of the descending thoracic aorta. Shahin GM, Hamerlijnck RP, Schepens MA, Ter Beek HT, Vermeulen FE, Boezeman EH

Since tibial nerve somatosensory evoked potentials (SEPs) recording is influenced by hemodynamic changes and anesthetics, alterations cannot always be attributed to spinal cord ischemia, so causing false positive results. Additional recording of median nerve SEPs facilitates interpretation. From January 1988 to July 1993, 60 consecutive patients (44 men, 16 women, mean age 66 years, ranging from 26 to 83 years) underwent surgery for an aneurysm of the descending thoracic aorta using a non-hepari... Abstract

Cited 2 times since 1996 (0.1 per year) source: EuropePMC

Journal of cardiovascular pharmacology, Volume 28 Suppl 1, 1 1 1996, Pages S37-44 Magnetic resonance techniques for assessment of myocardial viability. van der Wall EE, Vliegen HW, de Roos A, Bruschke AV

In general, the following three standards for myocardial viability can be used: (a) preserved coronary flow (adequate perfusion); (b) preserved wall motion (systolic wall thickening); and (c) preserved metabolism (metabolic integrity). The current magnetic resonance (MR) techniques provide a great potential to measure all three standards of viability. Adequate perfusion can be assessed by spin-echo MR imaging and/or ultrafast MR imaging, systolic wall thickening by cine MR imaging, and the prese... Abstract

Clinical science (London, England : 1979), Volume 91 Suppl, 1 1 1996, Pages 113-115 Heart rate variability, baroreflex sensitivity, and cardiac vagal tone. Swenne CA, Bootsma M, Hyndman BW, Voogd J, Bruschke AV

Abstract

Cited 6 times since 1995 (0.2 per year) source: EuropePMC

European heart journal, Volume 16, Issue 12, 1 1 1995, Pages 1860-1871 Comparison between regional myocardial perfusion reserve and coronary flow reserve in the canine heart. Geldof MJ, Schalij MJ, Manger Cats V, van der Zwet PM, Steendijk P, van der Velde ET, Nagtegaal EM, Reiber JH, Bruschke AV

Diameter stenosis and flow reserve are indices of morphological and functional severity of coronary artery stenosis. Flow reserve can be determined at coronary arterial or at myocardial level. In the presence of functional collateral circulation, coronary flow reserve and myocardial perfusion reserve may differ. We studied coronary flow, coronary flow reserve and myocardial perfusion reserve in an open chest dog model with intact collateral circulation, before and after induction of coronary art... Abstract

Cited 4 times since 1995 (0.1 per year) source: EuropePMC

Cell calcium, Volume 18, Issue 6, 1 1 1995, Pages 515-525 Alpha-adrenergic agonist and endothelin-1 induced intracellular Ca2+ response in the presence of a Ca2+ entry blocker in cultured rat ventricular myocytes. De Jonge HW, Atsma DE, van der Valk-Kokshoorn EJ, van Heugten HA, van der Laarse A, Lamers JM

Previously we demonstrated that stimulation of cultured neonatal rat ventricular myocytes by either alpha 1-adrenergic agonist or endothelin-1 resulted in a rapid formation of total inositolphosphates, although the levels of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate did not rise significantly. The aim of this study was to examine whether stimulation by alpha 1-adrenergic agonist and endothelin-1 could still elicit phosphatidylinositol cycle mediated intracellular Ca2+ m... Abstract

Cited 5 times since 1995 (0.2 per year) source: EuropePMC

American heart journal, Volume 130, Issue 5, 1 1 1995, Pages 1020-1025 Heart rate variability profiles in symptomatic coronary artery disease and preserved left ventricular function: relation to ventricular tachycardia and transient myocardial ischemia. Regression Growth Evaluation Statin Study (REGRESS). van Boven AJ, Jukema JW, Crijns HJ, Lie KI

We studied heart rate variability in ambulatory electrocardiographic recordings from 312 patients with significant coronary artery disease and a left ventricular ejection fraction of > or = 30%. Only those patients who had both episodes of ischemia and nonsustained ventricular arrhythmias showed diminished values for parasympathetic nonspectral and spectral heart rate (HR) variability parameters. The root mean square of difference of successive R-R intervals (RMSSD) and high-frequency (HF) po... Abstract

Cited 147 times since 1995 (5 per year) source: EuropePMC

Circulation, Volume 92, Issue 9, 1 1 1995, Pages 2419-2425 Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program. Byington RP, Jukema JW, Salonen JT, Pitt B, Bruschke AV, Hoen H, Furberg CD, Mancini GB