Research

Publications

Below you can find a list of our published research.

6125 results

Cited 51 times since 1995 (1.7 per year) source: EuropePMC

Circulation, Volume 91, Issue 7, 1 1 1995, Pages 2010-2017 Beat-to-beat analysis of left ventricular pressure-volume relation and stroke volume by conductance catheter and aortic Modelflow in cardiomyoplasty patients. Schreuder JJ, van der Veen FH, van der Velde ET, Delahaye F, Alfieri O, Jegaden O, Lorusso R, Jansen JR, van Ommen V, Finet G

Background: Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. Methods and results: We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 months after operation. Conductance and micromanometer catheters were placed in left ventricle and aorta and used for measurements over a 15-second period, during which the wrapped lat... Abstract

Cited 4 times since 1995 (0.1 per year) source: EuropePMC

The Journal of investigative dermatology, Volume 104, Issue 3, 1 1 1995, Pages 374-378 Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts. Boxman IL, Quax PH, Löwik CW, Papapoulos SE, Verheijen J, Ponec M

The plasminogen activator (PA)/plasmin system is thought to be involved in processes such as tumor invasion and wound healing, during which epithelial and mesenchymal cells come close together. However, information on regulation of the PA/plasmin system during epithelial-mesenchymal interactions is scarce. Therefore, we examined the in vitro modulation of the production and activity of the components of the PA/plasmin system in squamous carcinoma cells (SCC-4) and normal human keratinocytes in r... Abstract

Cited 59 times since 1995 (2 per year) source: EuropePMC

Virology, Volume 207, Issue 2, 1 1 1995, Pages 518-527 Identification of a neutralization site in the major envelope glycoprotein (GL) of equine arteritis virus. Balasuriya UB, Maclachlan NJ, De Vries AA, Rossitto PV, Rottier PJ

A panel of six neutralizing monoclonal antibodies (MAbs), neutralization-resistant variant (escape mutant [EM]) viruses, and individual viral proteins derived from a vaccinia virus expression system were used to identify the neutralizing determinants of equine arteritis virus (EAV). The neutralizing MAbs recognize a single neutralization site on the 29-kDa envelope glycoprotein of EAV (U. B. R. Balasuriya et al., 1993, J. Gen. Virol., 74, 2525-2529). Vaccinia virus recombinants which express eit... Abstract

Cited 122 times since 1995 (4.1 per year) source: EuropePMC

Circulation research, Volume 76, Issue 2, 1 1 1995, Pages 199-208 cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells. Draijer R, Atsma DE, van der Laarse A, van Hinsbergh VW

Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an endogenous modulator of endothelial barrier function. Thrombin increased the passage of macromolecules through human umbilical vein and human aortic endothelia... Abstract

Cited 11 times since 1995 (0.4 per year) source: EuropePMC

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Volume 139, 1 1 1995, Pages 105-122 Properties of metastasizing and nonmetastasizing human melanoma cells. van Muijen GN, Danen EH, de Vries TJ, Quax PH, Verheijen JH, Ruiter DJ

Dissemination of tumor cells includes several steps, such as: (a) detachment of tumor cells from the primary tumor, (b) traversement of the basement membrane, and (c) migration into the extracellular matrix. In these processes, at least two important categories of proteins are involved: proteases and adhesion molecules. In this contribution we describe the expression and function of components of the plasminogen activator (PA) system (proteases) and of integrins (cell-matrix adhesion molecules)... Abstract

Cited 21 times since 1995 (0.7 per year) source: EuropePMC

The American journal of cardiovascular pathology, Volume 5, Issue 1, 1 1 1995, Pages 27-31 Polyploidy of myocyte nuclei in pressure overloaded human hearts: a flow cytometric study in left and right ventricular myocardium. Vliegen HW, Eulderink F, Bruschke AV, van der Laarse A, Cornelisse CJ

Increased heart weight is known to be associated with polyploidy of myocardial nuclei. However, the relation between polyploidy and myocardial hypertrophy at a cellular level, i.e. myocyte hypertrophy, has not yet been investigated. The present study was conducted to reveal this relation in different regions in the heart using two recently developed techniques, i.e. flow cytometry to measure polyploidy and microscopic morphometry to measure myocyte dimensions in fixed tissue sections. We investi... Abstract

Cited 21 times since 1995 (0.7 per year) source: EuropePMC

The Journal of pathology, Volume 175, Issue 1, 1 1 1995, Pages 59-67 Components of the plasminogen activation system in uveal melanoma--a clinico-pathological study. De Vries TJ, Mooy CM, Van Balken MR, Luyten GP, Quax PH, Verspaget HW, Weidle UH, Ruiter DJ, Van Muijen GN

In tumour development, proteases such as plasminogen activators (PAs) play a role in degradation of the extracellular matrix and other tissue barriers. Recently, we demonstrated that plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of cutaneous melanocytic tumour progression. In this study we investigated the expression and distribution of the various components of the PA system and the presence of PA enzyme activity in 45 freshly frozen primary uveal melano... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 138, Issue 50, 1 1 1994, Pages 2502-2506 [Nitric oxide to combat pulmonary hypertension in an infant following heart surgery for septum defect]. Gesink-van der Veer BJ, Hazekamp MG, de Beaufort AJ, Stolk B, Helbing WA

A 5-month-old female infant with Down syndrome underwent surgical repair of a complete atrioventricular septal defect and a patent ductus arteriosus. The postoperative course was complicated by life-threatening pulmonary hypertensive crises which did not respond to conventional vasodilating therapy. Nitric oxide inhalation resulted in rapid decrease in pulmonary artery pressure and improvement of haemodynamics and oxygenation without causing any untoward side effects. Inhalation of NO was contin... Abstract

Cited 40 times since 1994 (1.3 per year) source: EuropePMC

Gastroenterology, Volume 107, Issue 5, 1 1 1994, Pages 1449-1456 Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis. Sier CF, Vloedgraven HJ, Ganesh S, Griffioen G, Quax PH, Verheijen JH, Dooijewaard G, Welvaart K, van de Velde CJ, Lamers CB

Background/aims: Human colorectal carcinogenesis was previously found to be associated with an increased urokinase-type plasminogen activator expression, both in antigen and activity, accompanied by simultaneously enhanced levels of plasminogen activator inhibitors type 1 and type 2. This increased proteolytic activity may contribute to invasive growth and metastasis of the tumors. Methods: In the present study, homogenates of liver metastases, primary colorectal carcinomas, and adjacent normal... Abstract

Cited 3 times since 1994 (0.1 per year) source: EuropePMC

Surgical endoscopy, Volume 8, Issue 11, 1 1 1994, Pages 1335-1337 Liver fibrosis after extracorporeal shock-wave lithotripsy of gallbladder stones. A case report. Plaisier PW, Hamming JF, van der Hul RL, den Toom R, Bruining HA

We encountered significant liver fibrosis in a healthy young patient undergoing laparoscopic cholecystectomy for symptomatic gallstone disease. Twelve months prior to cholecystectomy the patient underwent multiple extracorporeal shock-wave lithotripsy (ESWL) sessions with adjuvant oral bile-acid therapy. Since the site of fibrosis corresponded clearly to the shock-wave transmission path, which was in accordance with animal studies, it was concluded that this liver fibrosis was a side effect of b... Abstract

Cited 2 times since 1994 (0.1 per year) source: EuropePMC

The American journal of physiology, Volume 267, Issue 5 Pt 2, 1 1 1994, Pages H1895-906 Determinants of end-systolic pressure during different load alterations in the in situ left ventricle. van der Linden LP, van der Velde ET, van Houwelingen HC, Bruschke AV, Baan J

Because of the strong dependency of the end-systolic pressure-volume relation on the type of transient loading intervention in the in situ left ventricle (LV), experiments in the basal inotropic state in 16 open-chest anesthetized dogs were reanalyzed to find additional variables to model and predict end-systolic pressure (ESP) of both afterloading and preloading interventions by a single equation. Random-coefficients regression analysis was performed on 22 experiments in the basal inotropic sta... Abstract

Cited 1 times since 1994 (0 per year) source: EuropePMC

The British journal of nutrition, Volume 72, Issue 4, 1 1 1994, Pages 567-577 Dietary fructose v. glucose in rats raises urinary excretion, true absorption and ileal solubility of magnesium but decreases magnesium retention. van der Heijden A, van den Berg GJ, Lemmens AG, Beynen AC

Apparent Mg absorption, that is Mg intake minus faecal excretion, was found to be greater in rats fed on diets containing fructose instead of glucose. This effect of fructose was accompanied by enhanced urinary excretion and diminished retention of Mg. True Mg absorption was then determined with the use of oral and intraperitoneal administration of tracer doses of 28 Mg. True Mg absorption was significantly greater in rats fed on fructose. There was no significant effect of fructose v. glucose o... Abstract

Cited 4 times since 1994 (0.1 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 428, Issue 3-4, 1 1 1994, Pages 296-299 A novel two-compartment culture dish allows microscopic evaluation of two different treatments in one cell culture simultaneously. Influence of external pH on Na+/Ca2+ exchanger activity in cultured rat cardiomyocytes. Atsma DE, Bastiaanse EM, Ince C, van der Laarse A

A new type of culture dish containing two separate compartments is described, that can be used in high-magnification microscopy. Using the dish, two halves of a single-cell culture, grown on a standard coverslip, can be exposed to different treatments simultaneously, allowing the effect of one treatment to be compared with that of the other treatment in the same culture. This way, the natural variability that might exist between different individual cultures is circumvented. In addition, by simu... Abstract

Cited 42 times since 1994 (1.4 per year) source: EuropePMC

The Journal of general virology, Volume 75 ( Pt 9), 1 1 1994, Pages 2439-2444 Monoclonal antibodies to equine arteritis virus proteins identify the GL protein as a target for virus neutralization. Deregt D, de Vries AA, Raamsman MJ, Elmgren LD, Rottier PJ

Monoclonal antibodies (MAbs) to equine arteritis virus (EAV) proteins were produced and characterized. The protein specificities of eight MAbs were determined definitively by immunoprecipitation of EAV proteins expressed from vaccinia virus recombinants (VVRs). Included were two new VVRs produced for this study, expressing the M and the GL proteins, respectively. Three MAbs were determined to be N-specific and five MAbs recognized the GL protein. One GL-specific MAb, 17F5, of the IgA class, effi... Abstract

Cited 6 times since 1994 (0.2 per year) source: EuropePMC

Der Urologe. Ausg. A, Volume 33, Issue 5, 1 1 1994, Pages 392-400 [Urologic complications after kidney transplantation. Experiences in a center with 539 recipients]. Conrad S, Schneider AW, Gonnermann D, Ganama A, Tenschert W, Huland H

A total of 539 renal transplantations were performed at the Department of Urology of the University Hospital of Hamburg between 1984 and 1991. 132 (24.5%) patients developed urological complications (by definition, complications occurring as a result of the operative procedure). In 31 cases the transplants had to be removed secondary to urological complications, and 4 patients died of such complications (mortality 0.7%, lethality 3.0%). Urinary tract infections occurred in 13.2% of all patients... Abstract

Cited 19 times since 1994 (0.6 per year) source: EuropePMC

The Journal of urology, Volume 152, Issue 3, 1 1 1994, Pages 906-909 Endo-urological cold-knife incision for ureteral stenosis after renal transplantation. Conrad S, Schneider AW, Tenschert W, Meyer-Moldenhauer WH, Huland H

Cold-knife incision of stenoses in the transplant ureter was performed in 11 patients with upper urinary tract obstruction in renal transplants. The operations were complicated by bleeding in 2 patients and the graft had to be removed in 1 of them. The stenoses could be treated successfully in 10 of the 11 patients (91%) and the mean serum creatinine concentration decreased significantly from 3.4 to 1.8 mg./dl. After a mean of 26 months only 1 obstruction recurred, so the long-term success rate... Abstract

Cited 31 times since 1994 (1 per year) source: EuropePMC

Basic research in cardiology, Volume 89, Issue 5, 1 1 1994, Pages 411-426 Dependence of anisotropic myocardial electrical resistivity on cardiac phase and excitation frequency. Steendijk P, van der Velde ET, Baan J

Knowledge of myocardial electrical resistivity is of interest because passive electrical properties govern the electrotonic spread of current through the myocardium and influence the shape and velocity of the excitation wave. In addition, measurements of myocardial resistivity may provide information about tissue structure and components. The aim of the present study was to determine the excitation frequency dependence and the changes during the cardiac cycle of anisotropic myocardial electrical... Abstract

Cited 12 times since 1994 (0.4 per year) source: EuropePMC

Arteriosclerosis and thrombosis : a journal of vascular biology, Volume 14, Issue 9, 1 1 1994, Pages 1459-1465 Tissue-type plasminogen activator and its inhibitor in rat aorta. Effect of endotoxin. Padró T, Quax PH, van den Hoogen CM, Roholl P, Verheijen JH, Emeis JJ

Plasminogen activator (PA) and PA inhibitor (PAI) antigen, activity, and mRNA were analyzed in the three layers of rat aorta, and the effect of endotoxin on PA and PAI was studied. All PA activity in aorta was identified as tissue-type PA (TPA) activity; no urokinase-type PA was detected. In the tunica adventitia TPA activity, TPA antigen, and TPA mRNA were detected, whereas in the tunica media TPA antigen and TPA mRNA, but no TPA activity, were found. PAI activity was detected in the tunica med... Abstract

Cited 26 times since 1994 (0.8 per year) source: EuropePMC

Archives of biochemistry and biophysics, Volume 313, Issue 1, 1 1 1994, Pages 58-63 The effect of sarcolemmal cholesterol content on intracellular calcium ion concentration in cultured cardiomyocytes. Bastiaanse EM, Atsma DE, Kuijpers MM, Van der Laarse A

In this study the relationship between sarcolemmal free cholesterol content and intracellular calcium ion concentration ([Ca2+]i) was explored. In cultured neonatal rat cardiomyocytes the cellular free cholesterol content was modulated by treatment with liposomes. Using cholesterol-rich or cholesterol-free liposomes, sarcolemmal free cholesterol content was raised or diminished, respectively. An increased sarcolemmal free cholesterol content resulted in a decreased sarcolemmal fluidity, whereas... Abstract

Cited 18 times since 1994 (0.6 per year) source: EuropePMC

Electroencephalography and clinical neurophysiology, Volume 93, Issue 3, 1 1 1994, Pages 163-168 Fasciculation potentials in foot and leg muscles of healthy young adults. Van der Heijden A, Spaans F, Reulen J

The occurrence of fasciculation potentials (FPs) was studied in healthy subjects aged 18-25. In 25 males and 25 females 3 intrinsic foot muscles, the tibialis anterior and the gastrocnemius muscles on both sides were monitored with surface electrodes for 2 min periods. Only potentials with a peak-to-peak amplitude of at least 50 microV were counted. The number of FPs per minute (FPs/min) was significantly higher in the abductor hallucis (AH) and significantly lower in the tibialis anterior as co... Abstract