Research

Publications

Below you can find a list of our published research.

6173 results

Cited 31 times since 2022 (11.4 per year) source: EuropePMC

JACC. Cardiovascular interventions, Volume 15, Issue 16, 1 1 2022, Pages 1664-1674 Impact of Moderate Aortic Stenosis on Long-Term Clinical Outcomes: A Systematic Review and Meta-Analysis. Coisne A, Scotti A, Latib A, Montaigne D, Ho EC, Ludwig S, Modine T, Généreux P, Bax JJ, Leon MB, Bauters C, Granada JF

Background: The clinical course of patients with moderate aortic stenosis (AS) remains incompletely defined. Objectives: This study sought to analyze the clinical course of moderate AS and compare it with other stages of the disease. Methods: Multiple electronic databases were searched to identify studies on adult moderate AS. Random-effects models were used to derive pooled estimates. The primary endpoint was all-cause death. The secondary endpoints were cardiac death, heart failure, sudden dea... Abstract

Cited 48 times since 2022 (17.6 per year) source: EuropePMC

European heart journal, Volume 43, Issue 32, 1 1 2022, Pages e1-e9 A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy. Cadrin-Tourigny J, Bosman LP, Nozza A, Wang W, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC, van der Heijden JF, Tandri H, Jongbloed JDH, Guertin MC, van Tintelen JP, Platonov PG, Duru F, Haugaa KH, Khairy P, Hauer RNW, Calkins H, Te Riele ASJM, James CA

Aims: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interq... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 62, Issue 3, 1 1 2022, Pages ezac240 Mechanical circulatory support in the failing systemic right ventricle: a step towards better outcome. Koolbergen DR

Abstract

Cited 37 times since 2022 (13.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 5, 1 1 2022, Pages 545-561 Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review. Pibarot P, Herrmann HC, Wu C, Hahn RT, Otto CM, Abbas AE, Chambers J, Dweck MR, Leipsic JA, Simonato M, Rogers T, Sathananthan J, Guerrero M, Ternacle J, Wijeysundera HC, Sondergaard L, Barbanti M, Salaun E, Généreux P, Kaneko T, Landes U, Wood DA, Deeb GM, Sellers SL, Lewis J, Madhavan M, Gillam L, Reardon M, Bleiziffer S, O'Gara PT, Rodés-Cabau J, Grayburn PA, Lancellotti P, Thourani VH, Bax JJ, Mack MJ, Leon MB, Heart Valve Collaboratory

Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural valve deterioration. The main objective of this summary of experts participating in a virtual workshop was to propose standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement with the goal of... Abstract

Cited 17 times since 2022 (6.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 5, 1 1 2022, Pages 527-544 Bioprosthetic Aortic Valve Hemodynamics: Definitions, Outcomes, and Evidence Gaps: JACC State-of-the-Art Review. Herrmann HC, Pibarot P, Wu C, Hahn RT, Tang GHL, Abbas AE, Playford D, Ruel M, Jilaihawi H, Sathananthan J, Wood DA, De Paulis R, Bax JJ, Rodes-Cabau J, Cameron DE, Chen T, Del Nido PJ, Dweck MR, Kaneko T, Latib A, Moat N, Modine T, Popma JJ, Raben J, Smith RL, Tchetche D, Thomas MR, Vincent F, Yoganathan A, Zuckerman B, Mack MJ, Leon MB, Heart Valve Collaboratory

A virtual workshop was organized by the Heart Valve Collaboratory to identify areas of expert consensus, areas of disagreement, and evidence gaps related to bioprosthetic aortic valve hemodynamics. Impaired functional performance of bioprosthetic aortic valve replacement is associated with adverse patient outcomes; however, this assessment is complicated by the lack of standardization for labelling, definitions, and measurement techniques, both after surgical and transcatheter valve replacement.... Abstract

Cited 14 times since 2022 (5.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 80, Issue 7, 1 1 2022, Pages 666-676 Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis. Stassen J, Ewe SH, Singh GK, Butcher SC, Hirasawa K, Amanullah MR, Pio SM, Sin KYK, Ding ZP, Sia CH, Chew NWS, Kong WKF, Poh KK, Leon MB, Pibarot P, Delgado V, Marsan NA, Bax JJ

Background: The prognostic implications of discordant grading in severe aortic stenosis (AS) are well known. However, the prevalence of different flow-gradient patterns and their prognostic implications in moderate AS are unknown. Objectives: The purpose of this study was to investigate the occurrence and prognostic implications of different flow-gradient patterns in patients with moderate AS. Methods: Patients with moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified and divided... Abstract

Cited 22 times since 2022 (8 per year) source: EuropePMC

Allergy, Volume 77, Issue 11, 29 5 2022, Pages 3398-3407 Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis. Spekhorst LS, Bakker D, Drylewicz J, Rispens T, Loeff F, Boesjes CM, Thijs J, Romeijn GLE, Loman L, Schuttelaar ML, van Wijk F, de Graaf M, de Bruin-Weller MS

Background: At present, no real-world studies are available on different dupilumab dosing regimens in controlled atopic dermatitis (AD). The aim of this study was to clinically evaluate a patient-centered dupilumab dosing regimen in patients with controlled AD and to relate this to serum drug levels and serum biomarkers. Methods: Ninety adult AD patients from the prospective BioDay registry were included based on their dupilumab administration interval according to a predefined patient-centered... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

JMIR formative research, Volume 6, Issue 7, 28 4 2022, Pages e38263 COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study. Dirikgil E, Brons K, Duindam M, Groeneveld GH, Geelhoed JJM, Heringhaus C, van der Boog PJM, Rabelink TJ, Bos WJW, Chavannes NH, Atsma DE, Teng YKO

Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals. Objective: The objective of our study was to determine patients' and health care professionals' experiences and satisfaction with employing the COVID-box. Methods: In this single-center, retrospective, observational study, patients and health care profess... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Journal of internal medicine, Volume 292, Issue 6, 27 4 2022, Pages 892-903 Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials. Lyko C, Blum MR, Abolhassani N, Stuber MJ, Del Giovane C, Feller M, Moutzouri E, Oberle J, Jungo KT, Collet TH, den Elzen WPJ, Poortvliet RKE, Du Puy RS, Dekkers OM, Trompet S, Jukema JW, Aujesky D, Quinn T, Westendorp R, Kearney PM, Gussekloo J, Van Heemst D, Mooijaart SP, Bauer DC, Rodondi N

Background: Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). Objective: To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibo... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 31, Issue 1, 27 4 2022, Pages 16-20 The Netherlands Heart Tissue Bank : Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository. Henkens MTHM, van Ast JF, Te Riele ASJM, Houweling AC, Amin AS, Nijveldt R, Antoni ML, Li X, Wehrens SMT, von der Thüsen JH, Damman K, Ter Horst EN, Manintveld OC, Abma-Schouten RY, Niessen HWM, Silljé HHW, Jukema JW, Doevendans PA

Aim: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This de... Abstract

Cited 6 times since 2022 (2.2 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 115, Issue 6, 21 3 2022, Pages 1396-1402 The Aortic Root in Acute Type A Dissection: Repair or Replace? Arabkhani B, Verhoef J, Tomšič A, van Brakel TJ, Hjortnaes J, Klautz RJM

Background: The effect of an "aggressive" approach on the aortic root in acute type A aortic dissection (ATAAD) remains insufficiently explored. Methods: Retrospective analysis was conducted between 1992 and 2020 of a single-center, prospective cohort of consecutive patients aged ≥18 years diagnosed with ATAAD. Patients were divided into 2 groups: aortic root replacement (ARR; prosthetic or valve-sparing root replacement, n = 141) and conservative root approach (CRA; root sparing of pa... Abstract

Cited 8 times since 2022 (2.9 per year) source: EuropePMC

International journal of cardiology. Heart & vasculature, Volume 42, 19 3 2022, Pages 101086 Dyspnea in patients with atrial fibrillation: Mechanisms, assessment and an interdisciplinary and integrated care approach. van der Velden RMJ, Hermans ANL, Pluymaekers NAHA, Gawalko M, Elliott A, Hendriks JM, Franssen FME, Slats AM, van Empel VPM, Van Gelder IC, Thijssen DHJ, Eijsvogels TMH, Leue C, Crijns HJGM, Linz D, Simons SO

Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is often associated with symptoms that can significantly impact quality of life and daily functioning. Palpitations are the cardinal symptom of AF and many AF therapies are targeted towards relieving this symptom. However, up to two-third of patients also complain of dyspnea as a predominant self-reported symptom. In clinical practice it is often challenging to ascertain whether dyspnea represents an AF-related sympt... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

Urologie (Heidelberg, Germany), Volume 61, Issue 12, 19 3 2022, Pages 1365-1372 [Acceptance and status of digitalization in clinics and practices : Current assessment in German urology]. Borkowetz A, Leitsmann M, Baunacke M, Borgmann H, Boehm K, Groeben C, Roigas J, Schneider AW, Speck T, Schroeder-Printzen I, Zillich S, Volkmer B, Witzsch U, Huber J, Arbeitskreis Versorgungsforschung, Qualität und Ökonomie der Deutschen Gesellschaft für Urologie e V, Arbeitskreis Informationstechnologie und Dokumentation der Deutschen Gesellschaft für Urologie e V

Background: Digitalization of patient documentation and introduction of the electronic patient record (ePA) pose challenges to everyday clinical practice. Objectives: We investigated the acceptance and status of the digitalization of patient data and the introduction of the ePA among German urologists. Materials and methods: A questionnaire with 30 questions about the acceptance and status of digitalization of patient documentation and ePA was sent out via the newsletter of the German Society of... Abstract

The international journal of cardiovascular imaging, Volume 38, Issue 12, 19 3 2022, Pages 2771-2779 Left ventricular assist device and pump thrombosis: the importance of the inflow cannula position. Kortekaas KA, de Graaf MA, Palmen M, Braun J, Mertens BJA, Tops LF, Beeres SLMA

Pump thrombosis is a devastating complication after left ventricular assist device implantation. This study aims to elucidate the relation between left ventricular assist device implantation angle and risk of pump thrombosis. Between November 2010 and March 2020, 53 left ventricular assist device-patients underwent a computed tomography scan. Using a 3-dimensional multiplanar reformation the left ventricular axis was reconstructed to measure the implantation angle of the inflow cannula. All pati... Abstract

Cited 7 times since 2022 (2.5 per year) source: EuropePMC

Journal of the European Academy of Dermatology and Venereology : JEADV, Volume 36, Issue 11, 19 3 2022, Pages 2153-2165 Systemic treatment of children and adolescents with atopic dermatitis aged ≥2 years: a Delphi consensus project mapping expert opinion in Northern Europe. de Graaf M, Janmohamed SR, Schuttelaar MLA, Agner T, Alfonso JH, De Schepper S, Deleuran M, Despontin K, Elenius V, Ghislain PD, Huilaja L, Johansson EK, Kvenshagen BK, Mandelin JM, Olset H, Svensson A, van Tuyll van Serooskerken AM, Thyssen JP, Vestergaard C

Background: Paediatric atopic dermatitis (AD) can be burdensome, affecting mental health and impairing quality of life for children and caregivers. Comprehensive guidelines exist for managing paediatric AD, but practical guidance on using systemic therapy is limited, particularly for new therapies including biologics and Janus kinase (JAK) inhibitors, recently approved for various ages in this indication. Objectives: This expert consensus aimed to provide practical recommendations within this ad... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 38, Issue 12, 18 3 2022, Pages 2687-2693 Prognostic value of left atrial volume index in degenerative mitral stenosis. Yedidya I, Butcher SC, Stassen J, van der Bijl P, Ngiam JN, Chew NWS, Sia CH, Leow R, Li TY, Kong WKF, Poh KK, Kornowski R, Marsan NA, Delgado V, Bax JJ

Purpose: Degenerative mitral stenosis (DMS) is associated with a poor prognosis. Although mean transmitral gradient (TMG) has shown a good correlation with outcome, little is known about the association between other echocardiographic parameters and prognosis in patients with DMS. The current study aimed to evaluate the prognostic value of left atrial volume index (LAVI) in patients with DMS. Methods: A total of 155 patients with DMS (72[63-80] years, 67% female) were included. The population wa... Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 9, Issue 7, 18 3 2022, Pages 230 Left Atrial Remodeling after Mitral Valve Repair for Primary Mitral Regurgitation: Evolution over Time and Prognostic Significance. Stassen J, van Wijngaarden AL, Wu HW, Palmen M, Tomsic A, Delgado V, Bax JJ, Marsan NA

Left atrial (LA) dilatation is associated with worse outcomes in primary mitral regurgitation (MR). However, the effects of mitral valve repair on LA size and its prognostic implications are not well known. In the current study, LA volume index (LAVi) and LA reservoir strain (LASr) were evaluated immediately before and after surgery, and during long-term follow-up in 226 patients undergoing mitral valve repair for primary MR (age 62 ± 13 years, 66% male). Mean LAVi was reduced significantly afte... Abstract

Herzschrittmachertherapie & Elektrophysiologie, Volume 33, Issue 3, 16 3 2022, Pages 261-267 Imaging for risk stratification of sudden cardiac death. van der Bijl P, Bax JJ

Sudden cardiac death (SCD) can be effectively prevented with the use of implantable cardioverter-defibrillator (ICD). Current guidelines advocate an ICD for primary prevention in the presence of an left ventricular ejection fraction (LVEF) ≤ 35%. The majority of individuals that experience SCD, however, have an LVEF > 35%. Multimodality cardiac imaging has the ability to visualize the three factors responsible for arrhythmia-mediated SCD, namely substrate, trigger and modulator. Advances in c... Abstract

The European physical journal. C, Particles and fields, Volume 82, Issue 7, 16 3 2022, Pages 618 Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC. Abud AA, Abi B, Acciarri R, Acero MA, Adames MR, Adamov G, Adamowski M, Adams D, Adinolfi M, Aduszkiewicz A, Aguilar J, Ahmad Z, Ahmed J, Aimard B, Ali-Mohammadzadeh B, Alion T, Allison K, Monsalve SA, AlRashed M, Alt C, Alton A, Alvarez R, Amedo P, Anderson J, Andreopoulos C, Andreotti M, Andrews M, Andrianala F, Andringa S, Anfimov N, Ankowski A, Antoniassi M, Antonova M, Antoshkin A, Antusch S, Aranda-Fernandez A, Arellano L, Arnold LO, Arroyave MA, Asaadi J, Asquith L, Aurisano A, Aushev V, Autiero D, Lara VA, Ayala-Torres M, Azfar F, Back A, Back H, Back JJ, Backhouse C, Bagaturia I, Bagby L, Balashov N, Balasubramanian S, Baldi P, Baller B, Bambah B, Barao F, Barenboim G, Alzas PB, Barker G, Barkhouse W, Barnes C, Barr G, Monarca JB, Barros A, Barros N, Barrow JL, Basharina-Freshville A, Bashyal A, Basque V, Batchelor C, Chagas EBD, Battat JBR, Battisti F, Bay F, Bazetto MCQ, Alba JLLB, Beacom JF, Bechetoille E, Behera B, Beigbeder C, Bellantoni L, Bellettini G, Bellini V, Beltramello O, Benekos N, Mont

DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 × 6 × 6 m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the... Abstract

Cited 2 times since 2022 (0.7 per year) source: EuropePMC

The American journal of cardiology, Volume 179, 15 3 2022, Pages 64-69 Effects of Left Bundle Branch Block and Pacemaker Implantation on Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation. Dolci G, Singh GK, Wang X, van der Kley F, de Weger A, Bootsma M, Ajmone Marsan N, Bax JJ, Delgado V

Permanent pacemaker implantation (PPI) and left bundle branch block (LBBB) frequency after transcatheter aortic valve implantation (TAVI) and their effect on left ventricular ejection fraction (LVEF) remain controversial. We evaluated the incidence of PPI and new-onset LBBB after TAVI and their impact on LVEF at 6-month follow-up. Moreover, the impact of right ventricular (RV) pacing burden on changes in LVEF after TAVI was analyzed. The electrocardiograms of 377 patients (age 80 ± 7 years, 52%... Abstract