9543 results
Journal of cardiothoracic and vascular anesthesia,
Volume 39, Issue 8, 22 4 2025, Pages 2040-2048
Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery.
van Haeren MMT, Bozic C, Eberl S, Hollmann MW, Breel JS, Grewal N, Driessen AHG, Vlaar APJ, Müller MCA, Hermanns H
Objectives: This study aimed to analyze the impact of aortic valve morphology on preoperative coagulation status in patients undergoing elective thoracic aortic surgery. Preoperative ROTEM and conventional coagulation tests of patients with a bicuspid aortic valve (BAV) were compared to those with a tricuspid aortic valve (TAV). Design: An exploratory prospective observational study. Setting: Conducted in a single center. Participants: The study included 169 patients (63 BAV and 106 TAV). Interv...
Abstract
Cited 2 times since 2025 (3.4 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 41, Issue 6, 22 4 2025, Pages 1131-1140
Plaque burden improves the detection of ischemic CAD over stenosis from coronary computed tomography angiography.
Kero T, Bär S, Saraste A, Klén R, Bax JJ, Knuuti J, Maaniitty T
In symptomatic patients undergoing coronary CTA for suspected coronary artery disease (CAD), we assessed if quantification of plaque burden, in addition to luminal narrowing and clinical risk factors, offers incremental value for the identification of ischemic CAD on a per patient level. We evaluated 2145 patients who underwent coronary CTA for suspected CAD with sequential selective downstream 15O-water positron emission tomography (PET) myocardial perfusion imaging. Coronary CTA scans were ana...
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
Frontiers in pediatrics,
Volume 13, 22 4 2025, Pages 1511086
Current methods in the diagnosis of invasive meningococcal disease.
Ciftci E, Ocal D, Somer A, Tezer H, Yilmaz D, Bozkurt S, Dursun OU, Merter Ş, Dinleyici EC
Invasive meningococcal disease (IMD) remains a significant health concern due to its global distribution, potential for epidemic spread, unpredictable nature, rapid progression, and high mortality rates or permanent sequelae. The global elimination of meningococcal illness via immunization is a primary objective of the World Health Organization's strategy to defeat meningitis by 2030. Timely recognition of meningococcal infection and immediate, precise, and specific identification of Neisse...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 2, 18 3 2025, Pages rkae155
Improving efficiency of a rheumatology outpatient clinic through classification of newly referred patients.
Dijkstra S, de Man YA, Braaksma A, de Graaf M, Bernelot Moens HJ, Boucherie RJ
Objectives: Diagnosing a rheumatological disease in patients newly referred by their general practitioner requires assessment by a rheumatologist and often diagnostic tests. Ideally, these tests are performed prior to the patient's first consultation with the rheumatologist, aiming for quick diagnosis and fewer visits. We retrospectively studied whether a pre-first visit digital patient questionnaire can lead to fewer consultations and faster diagnosis. Methods: We applied machine learning-...
Abstract
Heart rhythm,
17 3 2025, Pages S1547-5271(25)02342-2
Visualization of acute atrial injury after ablation by contrast-enhanced T1-weighted short inversion time cardiac magnetic resonance imaging.
van Pouderoijen N, Hopman LHGA, Escartin T, Sheagren C, van Rosendael PJ, Allaart CP, Hofman MBM, Wright GA, Götte MJW
Abstract
Best practice & research. Clinical endocrinology & metabolism,
Volume 39, Issue 5, 17 3 2025, Pages 101998
Growth hormone replacement therapy in childhood-onset craniopharyngioma.
van Iersel L, van Schaik J, van Santen HM
Tumour- or treatment related growth hormone (GH) deficiency is often observed in children diagnosed or treated for childhood onset craniopharyngioma (cCP). Adequate and timely GH replacement therapy (GHRT) is important to improve growth velocity and final height during childhood. GHRT may be continued through adulthood due to its beneficial effects on metabolic health, bone health, mental health and quality of life. The current evidence suggests no increased risk for tumour progression or recurr...
Abstract
Cancers,
Volume 17, Issue 8, 17 3 2025, Pages 1352
Molecular-Targeted Fluorescence Lymph Node Imaging Could Play a Clinical Role in the Surgical Setting: A Systematic Review.
Zweedijk BE, Dalmeijer SWR, van Manen L, Galema HA, Lauwerends LJ, Abbasi H, Kremer B, Verhoef C, Robinson DJ, Koppes SA, Vahrmeijer AL, van der Vorst JR, Hilling DE, Keereweer S
The lymphatic system plays a crucial role in the spread of solid tumors and is often the first site of metastasis, as cancer cells typically invade nearby lymph nodes (LN) before potentially spreading to other LNs through the lymphatic system and distant organs through the bloodstream [...].
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society,
Volume 35, Issue 10, 17 3 2025, Pages 101831
APOLLO: neo-adjuvant pembrolizumab for primary vulvar squamous cell carcinoma-a multicenter, single-arm, phase II, clinical proof-of-concept study.
van Poelgeest MIE, Kortekaas KE, van Doorn HC, Oonk M, Nijman HW, Boere I, Eerkens AL, Reyners AKL, Ewing-Graham PC, Bart J, Bosse T, Welters MJP, Kroep JR, van der Burg SH
Background: Vulvar squamous cell carcinoma (VSCC) is a rare cancer for which the cornerstone of treatment is surgery with high complication rates. The unmet need is a less radical and more effective treatment for VSCC. Primary objectives: To investigate the impact of mono-immunotherapy pembrolizumab as neoadjuvant treatment for primary resectable VSCC patients. Study hypothesis: Some primary VSCC patients display a specific immune profile which is associated with better survival. In other tumors...
Abstract
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 51, Issue 8, 17 3 2025, Pages 110056
Metastasectomy versus stereotactic body radiotherapy for patients with oligometastatic colorectal lung metastases: a systematic review.
Gooijer SA, Gazendam ASM, Torensma B, Tuynman JB, Dahele M, Heineman DJ, Braun J, Dickhoff C, Senan S, Schreurs WH, Schneiders FL, van Dorp M
Metastasectomy and stereotactic body radiotherapy (SBRT) are both guideline-recommended treatment modalities for patients with oligometastatic colorectal lung metastases (CLM). Few evidence is available comparing different local therapies in an oligometastatic population. This systematic review aimed to compare the efficacy of metastasectomy with SBRT for patients with oligometastatic CLM. A systematic literature search was performed according to the PRISMA guidelines to identify studies on meta...
Abstract
Digestive diseases and sciences,
Volume 70, Issue 8, 16 3 2025, Pages 2786-2793
Obesity Is Associated with Inferior Clinical Treatment Outcomes in Inflammatory Bowel Disease: A Nationwide Dutch Registry Study.
Oomkens D, Mujagic Z, de Vries A, van der Meulen-de Jong A, Straatmijer T, Löwenberg M, van der Marel S, West R, Bodelier A, van Schaik F, Visschedijk M, Duijvestein M, Initiative on Crohn and Colitis (ICC)
Purpose: To examine the impact of obesity on treatment outcomes in inflammatory bowel disease (IBD). Methods: Patients aged ≥ 16 years, with IBD, a documented baseline body mass index (BMI), and starting thiopurines and allopurinol, intravenous (iv) vedolizumab, subcutaneous (sc) vedolizumab, ustekinumab, ozanimod, filgotinib, or tofacitinib were selected from the Dutch Initiative on Crohn and Colitis (ICC) registry. Underweight patients (BMI
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Cardiovascular drugs and therapy,
14 2 2025
Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY).
S Ramos K, Nassiri S, Wijdeveld LFJ, van der Palen RL, Kuipers MF, Hills MT, Slijkerman P, van Raalte DH, Handoko ML, de Groot NMS, Grewal N, Klautz RJM, Eringa EC, Brundel BJJM
Purpose: Interestingly, 30-50% of patients undergoing elective cardiothoracic surgery develop postoperative AF (PoAF). Unfortunately, preventive PoAF therapy is still suboptimal. In our previous studies, we showed that oral Geranylgeranylacetone (GGA) administration increased cardioprotective heat shock protein (HSP) protecting against AF onset and progression in clinically relevant animal model studies. Methods: The GENIALITY study is a phase II single-center, double-blind, placebo-controlled r...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 432, 11 2 2025, Pages 133269
Early aortic valve replacement versus conservative management in asymptomatic severe aortic stenosis: Meta-analysis of time-to-event data of randomized controlled trials.
Jacquemyn X, Sá MP, Marín-Cuartas M, Bax JJ, Borger MA, Clavel MA, Pibarot P, Généreux P, Sultan I
Background: Current guidelines recommend aortic valve replacement (AVR) for symptomatic patients with severe aortic stenosis (AS), but the optimal timing for intervention in asymptomatic patients is still debated. Recent randomized controlled trials (RCTs) have offered new insights, prompting a reevaluation of the potential benefits of early AVR. Methods: A systematic review and pooled meta-analysis of Kaplan-Meier-derived reconstructed time-to-event data of RCTs published by November 2024 was c...
Abstract
European journal of preventive cardiology,
9 2 2025, Pages zwaf193
Lifestyle behaviour change of patients following cardiac rehabilitation: the BENEFIT intervention study with one-year follow-up.
Breeman LD, Janssen VR, Kraaijenhagen RA, Al-Dhahir I, IJzerman RVH, Wolstencroft K, Kraaij W, Bonten TN, Atsma DE, Chavannes NH, van Gemert-Pijnen L, Kemps HMC, Scholte Op Reimer W, Evers AWM
Background: The majority of people with cardiovascular disease (CVD) do not maintain a healthy lifestyle. To help patients implement behaviour change at home, the BENEFIT programme was developed as an addition to cardiac rehabilitation (CR) care. Methods: Using a cluster non-randomised controlled trial design involving 7 CR centres, we examined whether intervention group patients (n=587) showed increased improvements in health behaviour change compared to control group patients (n=298) who (only...
Abstract
World journal of surgical oncology,
Volume 23, Issue 1, 8 2 2025, Pages 128
Re-do robot-assisted salvage lobectomy after esophagectomy with gastric pull-up reconstruction: a case report.
Shahin G, Kharbanda R, Tummers Q, Braun J
Background: Robot-assisted Thoracic Surgery (RATS) is well-established for complex minimally invasive thoracic surgery. Despite the available literature, robotics for complex advanced NSCLC for re-do surgery remains underexplored. Case presentation: We present a 55-year-old female who underwent esophagectomy with gastric pull-up reconstruction for squamous cell carcinoma (SCC) of the esophagus (cT3N2M0, stage IIIB) after neo-adjuvant concurrent chemoradiation therapy (ypT2N1 stage IIB disease)....
Abstract
Cited 6 times since 2025 (9.6 per year)
source: EuropePMC
Circulation,
Volume 151, Issue 14, 7 1 2025, Pages 1047-1050
Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES.
Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 12, Issue 4, 7 1 2025, Pages 140
Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.
Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N
(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Journal of hazardous materials,
Volume 492, 4 1 2025, Pages 138170
Estimating the emission of microplastics from urban surfaces into the atmosphere using the PI-SWERL.
Leitão IA, van Schaik L, Goossens D, Ferreira AJD, Geissen V
Microplastics (MPs) are a global concern, with the atmosphere being a key pathway for their transport. Understanding their sources is crucial for controlling MP dispersion. This study examines MPs on urban surfaces and their transport through wind erosion using a Portable In Situ Wind Erosion Laboratory (PI-SWERL) under two wind shear conditions. Material was collected in Coimbra, Portugal, from fourteen locations associated with different land uses. MPs number and types were determined with a s...
Abstract
Cited 4 times since 2025 (6.3 per year)
source: EuropePMC
Journal of the European Academy of Dermatology and Venereology : JEADV,
3 1 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.
van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS
Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2...
Abstract
BMJ nutrition, prevention & health,
Volume 8, Issue 1, 3 1 2025, Pages e001059
In-hospital nudging intervention increases patients' healthy dietary choices: a quasi-experimental study.
de Frel DL, Janssen VR, Wicks H, Bakk Z, van Keulen N, Kleinsmann MS, Assendelft WJ, Atsma D
Aims: Most hospitals still lag behind in their policies to stimulate healthier dietary choices by their patients. This study investigates whether a multicomponent nudging intervention, designed to prompt healthy food choices, can influence dietary choices of hospitalised patients. Methods: This pre-postintervention study included a baseline phase and an intervention phase (7+7 months) and was carried out at the cardiology ward of a large hospital. All 2419 cardiac patients admitted to the ward d...
Abstract
International journal of cardiology. Congenital heart disease,
Volume 20, 3 1 2025, Pages 100580
A 2:1 atrioventricular block in an adult patient with a Fontan circulation: from transesophageal pacing to echocardiographic guidance of epicardial pacemaker lead placement.
Smit JM, Regeer MV, Wijnmaalen AP, Jongbloed MRM, Hazekamp MG, Egorova AD
Background: The diagnosis and management of atrioventricular (AV)-conduction disorders in patients with a Fontan circulation can be challenging. Little is known about the effects of various pacing strategies in single-ventricle patients. Here we report 1) the feasibility of transesophageal electrophysiological study (EPS) to assess AV-conduction in a patient with limited venous access and 2) the potential of echocardiography to guide epicardial systemic right ventricular (sRV) lead positioning a...
Abstract
