Research

Publications

Below you can find a list of our published research.

9543 results

Cited 1 times since 2025 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 404, 3 1 2025, Pages 119184 Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study. Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D

Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the... Abstract

North American Spine Society journal, Volume 22, 2 1 2025, Pages 100609 Sexual health and chronic low back pain: A qualitative study. van Schaik D, Channa H, Fobelets M, Moens M, Scheerlinck T, Goudman L

Background: Chronic low back pain presents a major challenge to society and healthcare systems, with significant financial and personal consequences. Beyond physical limitations, it affects relationships and sexual well-being-an often-overlooked aspect. Reduced sexual activity and satisfaction can strain intimacy, heighten psychological stress, and amplify pain perception. Despite its importance, sexual health remains underdiscussed in clinical care, and research on this topic is limited. A holi... Abstract

Cited 1 times since 2025 (1.6 per year) source: EuropePMC

EJVES vascular forum, Volume 64, 2 1 2025, Pages 8-15 Strategies for Antithrombotic Management During Non-cardiac Arterial Procedures: Results of the International ACTION Survey. Hoebink M, Jongkind V, European Vascular Research Collaborative, ACTION-1 Research Collaborative

Objective: Peri-procedural antithrombotics are used extensively to prevent thromboembolic complications during non-cardiac arterial procedures (NCAP) worldwide. However, there is a lack of evidence to support recommendations on antithrombotic strategies, possibly leading to substantial variation in local practices. A comprehensive overview of antithrombotic strategies is needed to identify the most widely accepted protocols employed during NCAP, highlight variations in local practices, and ident... Abstract

Cited 4 times since 2025 (6.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 14, 1 1 2025, Pages 1471-1484 Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators

Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin... Abstract

Cited 6 times since 2025 (9.3 per year) source: EuropePMC

Diabetes care, Volume 48, Issue 4, 1 1 2025, Pages 596-604 Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial. Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG

Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and... Abstract

Multiple sclerosis journal - experimental, translational and clinical, Volume 11, Issue 2, 1 1 2025, Pages 20552173251335625 Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis. Yilmaz D, Adams C, Horton MK, Graves JS, Francisco C, Edwards A, Quach H, Quach D, Aaen G, Lotze T, Mar S, Ness J, Wheeler Y, Gorman MP, Benson L, Weinstock-Guttman B, Waldman A, Schreiner T, Tillema JM, Chitnis T, Rose J, Casper TC, Rensel M, Waubant E, Barcellos LF, Network of Pediatric Multiple Sclerosis Centers

Background and objectives: The genetic basis of adult-onset multiple sclerosis (MS) is well-studied, but less is known about pediatric-onset MS (pedMS), comprising approximately 5% of all MS onsets. Mendelian randomization (MR) studies have demonstrated evidence for a causal association between MS and both 25-hydroxyvitamin D [25(OH)D] serum levels and genetic variation related to vitamin D receptor (VDR) binding. The objective was to identify whether VDR binding variants (VDR-BVs) previously im... Abstract

European heart journal. Cardiovascular Imaging, Volume 26, Issue 5, 1 1 2025, Pages 918-927 The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting. Myagmardorj R, Fortuni F, Généreux P, Nabeta T, Stassen J, Galloo X, Meucci MC, Butcher S, van der Kley F, Cohen DJ, Clavel MA, Pibarot P, Leon MB, Regeer MV, Delgado V, Ajmone Marsan N, Bax JJ

Aims: This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Methods and results: Patients with severe aortic stenosis (AS) undergoing TAVI were retrospectively analysed. A five-stage system based on the presence and extent of cardiac damage assessed by echocardiography was applied before and 6 months after TAVI. Multivari... Abstract

Proceedings. IEEE International Symposium on Biomedical Imaging, Volume 2025, 1 1 2025 CT CONTRAST PHASE IDENTIFICATION BY PREDICTING THE TEMPORAL ANGLE USING CIRCULAR REGRESSION. Su D, Van Schaik KD, Remedios LW, Li T, Maldonado F, Sandler KL, Dawant BM, Landman BA

Contrast enhancement is widely used in computed tomography (CT) scans, where radiocontrast agents circulate through the bloodstream and accumulate in the vasculature, creating visual contrast between blood vessels and surrounding tissues. This work introduces a technique to predict the timing of contrast in a CT scan, a key factor influencing the contrast effect, using circular regression models. Specifically, we represent the contrast timing as unit vectors on a circle and employ 2D convolution... Abstract

Cited 1 times since 2025 (1.6 per year) source: EuropePMC

Acta anaesthesiologica Scandinavica, Volume 69, Issue 4, 1 1 2025, Pages e70021 Characteristics and outcomes of older patients undergoing out- versus inpatient surgery in Europe. A secondary analysis of the Peri-interventional Outcome Study in the Elderly (POSE). Grüßer L, Coburn M, Schmid M, Rossaint R, Ziemann S, Kowark A, POSE Study group

Background: The number of older patients undergoing surgical procedures with anaesthesia care is projected to rise. In order to cope with the increased demand, the expansion of outpatient surgery may play a decisive role. We aim to investigate the characteristics and outcomes of the older outpatient population. Patients and methods: The Peri-interventional Outcome Study in the Elderly in Europe (POSE) was a prospective multicenter study investigating characteristics and outcomes in 9497 patients... Abstract

Neural computation, Volume 37, Issue 5, 1 1 2025, Pages 926-956 The Leaky Integrate-and-Fire Neuron Is a Change-Point Detector for Compound Poisson Processes. Mani S, Hurley P, van Schaik A, Monk T

Animal nervous systems can detect changes in their environments within hundredths of a second. They do so by discerning abrupt shifts in sensory neural activity. Many neuroscience studies have employed change-point detection (CPD) algorithms to estimate such abrupt shifts in neural activity. But very few studies have suggested that spiking neurons themselves are online change-point detectors. We show that a leaky integrate-and-fire (LIF) neuron implements an online CPD algorithm for a compound P... Abstract

Cited 3 times since 2025 (4.7 per year) source: EuropePMC

Journal of Crohn's & colitis, Volume 19, Issue 4, 1 1 2025, Pages jjae166 Effectiveness of Transitional Care in Inflammatory Bowel Disease; Development, Validation, and Initial Outcomes of a Transition Success Score. van Gaalen MAC, van Pieterson M, Waaijenberg P, Kindermann A, Wolters VM, Dijkstra A, van Wering H, Wessels M, de Ridder L, Rizopoulos D, Derikx CLAAP, Escher JC, Kids with Crohn’s, Colitis (KiCC) Working Group for Collaborative Paediatric IBD Research in the Netherlands, the Dutch Initiative on Crohn and Colitis (ICC) and Dutch Nurses Network Inflammatory Bowel Disease (NIBD)

Background and aims: The effectiveness of transition programs from pediatric to adult healthcare in adolescents with inflammatory bowel disease (IBD) is not clear, as prospective studies using validated outcome measures for transition are lacking. This study aimed to develop and validate a quantitative Transition Success Score (TSS), and to apply it in a multicenter setting to assess the effectiveness of transitional care. Methods: The Top 10 outcome items related to a successful transition, ide... Abstract

The clinical teacher, Volume 22, Issue 2, 1 1 2025, Pages e70063 Navigating Crossroads: Collaborative Strategies to Assess and Enhance the Quality of Clinical Learning Environments. Daya S, Bernal J, van Schaik S

Abstract

The Review of scientific instruments, Volume 96, Issue 4, 1 1 2025, Pages 044504 Controlled partial gravity platform for milligravity in drop tower experiments. Joeris K, Keulen M, Kollmer JE

We detail a platform for partial gravity environment and an experiment for simulated impacts on asteroid surfaces based on it. The partial gravity environment is created by a two stage approach: First, we place the experiment in the microgravity of a free-falling drop tower capsule in the ZARM (German acronym for Center of Applied Space Technology and Microgravity) Bremen drop tower. Second, we convert microgravity to partial gravity by steady acceleration of the experiment volume on a linear dr... Abstract

Cited 8 times since 2025 (12.4 per year) source: EuropePMC

Cardiovascular research, Volume 121, Issue 1, 1 1 2025, Pages 143-156 miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues. Senesi G, Lodrini AM, Mohammed S, Mosole S, Hjortnaes J, Veltrop RJA, Kubat B, Ceresa D, Bolis S, Raimondi A, Torre T, Malatesta P, Goumans MJ, Paneni F, Camici GG, Barile L, Balbi C, Vassalli G

Aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results: Gain- and loss-of-function experiments were performed using human induced pluripotent stem cell-derived cardiomyoc... Abstract

Cited 4 times since 2025 (6.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 18, Issue 6, 31 5 2025, Pages e018235 AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry. Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho G, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, Van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A

Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACEs). Methods: Global multicenter registry including symptomatic patients with suspicion of coronary artery... Abstract

Cited 2 times since 2025 (3.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 18, Issue 9, 29 5 2025, Pages 1013-1041 The Last Decade in Tricuspid Regurgitation: How Imaging Shaped a Field. Hahn RT, Badano L, Praz F, Muraru D, Agricola E, Ajmone Marsan N, Bartkowiak J, Delgado V, Dreyfus J, Hausleiter J, Lurz P, Maisano F, Margonato D, Messika-Zeitoun D, Enriquez-Sarano M, Cavalcante JL

The tricuspid valve has become a major focus of novel structural heart interventions, with the Conformité Européenne approval of 5 devices in Europe and the U.S. Food and Drug Administration approval of 2 devices in the United States. Multiple meta-analyses and large population-based registries have shown that although significant tricuspid regurgitation (TR) often accompanies left heart or pulmonary vascular diseases, it is associated with an increased risk of mortality and a reduced quality of... Abstract

Journal of cardiothoracic and vascular anesthesia, Volume 39, Issue 7, 29 5 2025, Pages 1681-1688 Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience. Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H

Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 5, 29 5 2025, Pages 991-1000 Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation. Nabeta T, Peters F, Wu HW, Chua AP, Palmen M, Tomšič A, Marsan NA, Bax JJ, van der Bijl P

Purpose: Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery. Methods and results: A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assess... Abstract

Cited 1 times since 2025 (1.5 per year) source: EuropePMC

Scientific reports, Volume 15, Issue 1, 28 4 2025, Pages 10694 Phylodynamic assessment of SNP distances from whole genome sequencing for determining Mycobacterium tuberculosis transmission. Van der Roest BR, Bootsma MCJ, Fischer EAJ, Gröschel MI, Anthony RM, de Zwaan R, Kretzschmar MEE, Klinkenberg D

The global tuberculosis (TB) epidemic is driven by primary transmission. Pathogen genome sequencing is increasingly used in molecular epidemiology and outbreak investigations. Based on contact tracing and epidemiological links, Single Nucleotide Polymorphism (SNP) cut-offs, ranging from 3 to 12 SNPs, identify probable transmission clusters or exclude direct transmission. However, contact tracing can be limited by recall bias and inconsistent methodologies across TB settings. We propose phylodyna... Abstract

Clinical case reports, Volume 13, Issue 4, 28 4 2025, Pages e70282 A <i>PDLIM7</i> Variant in Familial Mitral Valve Prolapse: A Case Series. van Wijngaarden AL, Koopmann TT, Ruivenkamp CAL, Wu HW, Ajmone Marsan N, Barge-Schaapveld DQCM

In the presented case of familial mitral valve prolapse, whole exome sequencing was used to reveal a missense variant in the PDLIM7 gene. This gene is considered a possible novel candidate gene for familial MVP based on PDLIM7 knock-out mice and zebrafish showing mitral valve abnormalities. Abstract