Research

Publications

Below you can find a list of our published research.

9543 results

Cited 14 times since 2024 (10.4 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 37, Issue 11, 17 3 2024, Pages 1083-1102 Advances in the Assessment of Patients With Tricuspid Regurgitation: A State-of-the-Art Review on the Echocardiographic Evaluation Before and After Tricuspid Valve Interventions. Badano LP, Tomaselli M, Muraru D, Galloo X, Li CHP, Ajmone Marsan N

Tricuspid regurgitation (TR) can have a significant impact on the health and mortality of a patient. Unfortunately, many patients with advanced right-sided heart failure are not referred for isolated tricuspid valve (TV) surgery in a timely manner. This delayed referral has resulted in a high in-hospital mortality rate and significant undertreatment. Fortunately, transcatheter TV intervention (TTVI) has emerged as a safe and effective alternative to surgery, successfully reducing TR severity and... Abstract

Cited 7 times since 2024 (5.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 17, Issue 7, 16 3 2024, Pages e016481 Rapid Plaque Progression Is Independently Associated With Hyperglycemia and Low HDL Cholesterol in Patients With Stable Coronary Artery Disease: A PARADIGM Study. Neglia D, Caselli C, Maffei E, Cademartiri F, Meloni A, Bossone E, Saba L, Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ

Background: We assessed whether combinations of cardiometabolic risk factors independently predict coronary plaque progression (PP) and major adverse cardiovascular events in patients with stable coronary artery disease. Methods: Patients with known or suspected stable coronary artery disease (60.9±9.3 years, 55.4% male) undergoing serial coronary computed tomography angiographies (≥2 years apart), with clinical characterization and follow-up (N=1200), were analyzed from the PARADIGM study (Prog... Abstract

Journal of clinical epidemiology, Volume 173, 15 3 2024, Pages 111464 Estimating uncertainty when providing individual cardiovascular risk predictions: a Bayesian survival analysis. Hageman SHJ, Post RAJ, Visseren FLJ, McEvoy JW, Jukema JW, Smulders Y, van Smeden M, Dorresteijn JAN, UCC-SMART Study Group

Background: Cardiovascular disease (CVD) risk scores provide point estimates of individual risk without uncertainty quantification. The objective of the current study was to demonstrate the feasibility and clinical utility of calculating uncertainty surrounding individual CVD-risk predictions using Bayesian methods. Study design and setting: Individuals with established atherosclerotic CVD were included from the Utrecht Cardiovascular Cohort-Secondary Manifestations of ARTerial disease (UCC-SMAR... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Critical reviews in oncology/hematology, Volume 202, 14 2 2024, Pages 104441 Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review. van Schaik LF, Engelhardt EG, Wilthagen EA, Steeghs N, Fernández Coves A, Joore MA, van Harten WH, Retèl VP

Comprehensive Genomic Profiling (CGP) allows for the identification of many targets. Reimbursement decision-making is, however, challenging because besides the health benefits of on-label treatments and costs, other factors related to diagnostic and treatment pathways may also play a role. The aim of this study was to identify which other factors are relevant for the technology assessment of CGP and to summarize the available evidence for these factors. After a scoping search and two expert sess... Abstract

Annals of vascular surgery, Volume 109, 14 2 2024, Pages 20-34 Lessons Learned from Dutch Medical Disciplinary Law Regarding Aortic Aneurysm and Dissection Care. Warmerdam BWCM, van der Vorst JR, van Schaik J, Hamming JF

Background: The current study is an explanatory analysis of Dutch disciplinary law regarding aortic aneurysm and aortic dissection care. We aim to give insight in the way disciplinary judges rule on quality of care and to extract the lessons to be learned. Methods: The online open-access governmental database, which includes all disciplinary rulings since 2010, was searched using search terms related to aortic aneurysm and dissection care. First, abstracts were screened for relevance. Thereafter... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Travel medicine and infectious disease, Volume 60, 14 2 2024, Pages 102739 Rabies knowledge gaps and risk behaviour in Dutch travellers: An observational cohort study. Overduin LA, Koopman JPR, Prins C, Verbeek-Menken PH, de Pijper CA, Heerink F, van Genderen PJJ, Grobusch MP, Visser LG

Background: Travellers visiting rabies-endemic countries are at risk of rabies infection. Assessing travellers' knowledge and risk perception of rabies and risk behaviour during travel can help identify knowledge gaps and improve pre-travel risk education. Methods: Cohort study in Dutch adult travellers, using two surveys: one before travel to assess knowledge and perception of rabies, and one after return to identify risk behaviour during travel. Results: The pre-travel and post-travel sur... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

European heart journal. Imaging methods and practice, Volume 2, Issue 3, 11 2 2024, Pages qyae069 Comparison of left ventricular mass and wall thickness between cardiac computed tomography angiography and cardiac magnetic resonance imaging using machine learning algorithms. van Driest FY, van der Geest RJ, Omara SK, Broersen A, Dijkstra J, Jukema JW, Scholte AJHA

Aims: Cardiac magnetic resonance imaging (MRI) is the gold standard in the assessment of left ventricle (LV) mass and wall thickness. In recent years, cardiac computed tomography angiography (CCTA) has gained widespread usage as an imaging modality. Despite this, limited previous investigations have specifically addressed the potential of CCTA as an alternative modality for quantitative LV assessment. The aim of this study was to compare CCTA derived LV mass and wall thickness with cardiac MRI u... Abstract

Cited 17 times since 2024 (12.4 per year) source: EuropePMC

Atherosclerosis, Volume 396, 11 2 2024, Pages 118540 Course of the effects of LDL-cholesterol reduction on cardiovascular risk over time: A meta-analysis of 60 randomized controlled trials. Burger PM, Dorresteijn JAN, Koudstaal S, Holtrop J, Kastelein JJP, Jukema JW, Ridker PM, Mosterd A, Visseren FLJ

Background and aims: Individuals with or at high risk of cardiovascular disease (CVD) often receive long-term treatment with low-density lipoprotein cholesterol (LDL-C) lowering therapies, but whether the effects of LDL-C reduction remain stable over time is uncertain. This study aimed to establish the course of the effects of LDL-C reduction on cardiovascular risk over time. Methods: Randomized controlled trials (RCTs) of LDL-C lowering therapies were identified through a search in MEDLINE and... Abstract

European heart journal. Case reports, Volume 8, Issue 7, 10 2 2024, Pages ytae339 Left ventricular apical pacing-induced heart failure in a child after congenital heart surgery: a case report. De Wolf R, van der Palen RLF, Ten Harkel ADJ, Hazekamp MG, Blom NA

Background: Left ventricular apical pacing (LVAP) is considered to preserve left ventricular (LV) systolic function in both patients with and without congenital heart disease. However, sporadic LVAP-associated cardiac dysfunction in children with complex structural heart disease was recently reported. We present the case of a 2.5-year-old child with complex congenital heart disease and LVAP-induced cardiomyopathy. Case summary: Corrective surgery for double outlet right ventricle, subpulmonary v... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese, 6 1 2024, Pages S1109-9666(24)00139-8 Right ventricular-pulmonary arterial coupling in patients with first acute myocardial infarction: an emerging post-revascularization triage tool. Anastasiou V, Daios S, Moysidis DV, Liatsos AC, Papazoglou AS, Didagelos M, Savopoulos C, Bax JJ, Ziakas A, Kamperidis V

Background: The tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio is a non-invasive surrogate for right ventricular-pulmonary arterial (RV-PA) coupling, studied in chronic RV pressure overload syndromes. However, its prognostic utility in patients with acute myocardial infarction (AMI), which may cause acute RV pressure overload, remains unexplored. Objective: This study aimed to determine predictors of RV-PA uncoupling in patients with first AMI an... Abstract

Cited 16 times since 2024 (11.6 per year) source: EuropePMC

Journal of clinical lipidology, Volume 18, Issue 5, 6 1 2024, Pages e685-e700 Addressing residual risk beyond statin therapy: New targets in the management of dyslipidaemias-A report from the European Society of Cardiology Cardiovascular Round Table. Mach F, Visseren FLJ, Cater NB, Salhi N, Soronen J, Ray KK, Delgado V, Jukema JW, Laufs U, Zamorano JL, Ros E, Plat J, Gesztes AG, Tokgozoglu L, Packard C, Libby P

Cardiovascular (CV) disease is the most common cause of death in Europe. Despite proven benefits, use of lipid-lowering therapy remains suboptimal. Treatment goals are often not achieved, even in patients at high risk with atherosclerotic CV disease (ASCVD). The occurrence of CV events in patients on lipid-lowering drugs is defined as "residual risk", and can result from inadequate control of plasma lipids or blood pressure, inflammation, diabetes, and environmental hazards. Assessment... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

Diabetes research and clinical practice, Volume 214, 6 1 2024, Pages 111772 The impact of diabetes mellitus on foot perfusion measured by ICG NIR fluorescence imaging. Koning S, van Kersen J, Tange FP, Kruiswijk MW, Peul RC, van Schaik J, Schepers A, Vahrmeijer AL, Hamming JF, van den Hoven P, van der Vorst JR

Introduction: Diabetes Mellitus (DM) is a common chronic disease, affecting 435 million people globally. Impaired vasculature in DM patients leads to complications like lower extremity arterial disease (LEAD) and foot ulcers, often resulting in amputations. DM causes additional peripheral neuropathy leading to multifactorial wound problems. Current diagnostics often deem unreliable, but Near-Infrared Fluorescence with Indocyanine Green (ICG NIR) can be used to assess the foot perfusion. Therefor... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

Journal of clinical medicine, Volume 13, Issue 13, 5 1 2024, Pages 3945 Changes in Global Longitudinal Strain after TAVI: Additional Prognostic Value over Cardiac Damage in Patients with Severe Aortic Stenosis. Myagmardorj R, Fortuni F, Galloo X, Nabeta T, Meucci MC, Butcher SC, van der Kley F, Bax JJ, Ajmone Marsan N

Background: Previous studies demonstrated the prognostic value of baseline cardiac damage staging as well as left ventricular global longitudinal strain (LVGLS) in patients undergoing transcatheter aortic valve implantation (TAVI). The aim of the present study was to evaluate the changes in cardiac damage stage and LVGLS after TAVI and to investigate their prognostic values when integrated into the follow-up assessment. Methods: Patients with severe aortic stenosis undergoing TAVI were hierarchi... Abstract

Cited 3 times since 2024 (2.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 32, Issue 7-8, 2 1 2024, Pages 290-297 Impact of symptom duration and mechanical circulatory support on prognosis in cardiogenic shock complicating acute myocardial infarction. Klein F, Crooijmans C, Peters EJ, van 't Veer M, Timmermans MJC, Henriques JPS, Verouden NJW, Kraaijeveld AO, Bunge JJH, Lipsic E, Sjauw KD, van Geuns RM, Dedic A, Dubois EA, Meuwissen M, Danse P, Bleeker G, Montero-Cabezas JM, Ferreira IA, Brouwer J, Teeuwen K, Otterspoor LC, PCI registration committee of the Netherlands Heart Registration

Background: Mortality rates in patients with cardiogenic shock complicating acute myocardial infarction (AMICS) remain high despite advancements in AMI care. Our study aimed to investigate the impact of prehospital symptom duration on the prognosis of AMICS patients and those receiving mechanical circulatory support (MCS). Methods and results: We conducted a retrospective cohort study with data registered in the Netherlands Heart Registration. A total of 1,363 patients with AMICS who underwent p... Abstract

Cited 4 times since 2024 (2.9 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 32, Issue 11, 2 1 2024, Pages 1371-1377 Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants. Beunk L, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw D, Deneer VHM, van Westrhenen R

The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by developing evidence-based guidelines to optimize pharmacotherapy based on pharmacogenetic test results. The current guideline describes the gene-drug interaction between CYP2D6 and venlafaxine, mirtazapine and duloxetine. In addition, the interaction between CYP2C19 and mirtazapine and moclobemide is presented. The DPWG identified a gene-drug interaction that requires therap... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

Cancer immunology, immunotherapy : CII, Volume 73, Issue 9, 2 1 2024, Pages 166 Monocyte infiltration is an independent positive prognostic biomarker in vulvar squamous cell carcinoma. Abdulrahman Z, Kortekaas KE, Welters MJP, van Poelgeest MIE, van der Burg SH

Background: Vulvar squamous cell carcinoma (VSCC) arises after an HPV infection or the mutation of p53 or other driver genes and is treated by mutilating surgery and/or (chemo) radiation, with limited success and high morbidity. In-depth information on the immunological make up of VSCC is pivotal to assess whether immunotherapy may form an alternative treatment. Methods: A total of 104 patient samples, comprising healthy vulva (n = 27) and VSCC (n = 77), were analyzed. Multispectral immunofluore... Abstract

Cited 5 times since 2024 (3.6 per year) source: EuropePMC

Minerva cardiology and angiology, Volume 73, Issue 2, 1 1 2024, Pages 219-237 Echocardiographic assessment of patient hemodynamics in heart failure. Fortuni F, Morroni S, Biagioli P, Myagmardorj R, Viti C, Sforna S, Moscatelli S, Wu HW, Ambrosio G, Bax JJ, Ajmone Marsan N, Carluccio E

Heart failure (HF) is a clinical syndrome which is due to cardiac structural and/or functional abnormalities that result in elevated intra-cardiac pressures and/or inadequate cardiac output. Hemodynamic assessment in HF allows the identification and characterization of cardiac dysfunction, systemic and/or pulmonary congestion and the eventual impairment of systemic perfusion which are fundamental to phenotype HF, risk stratify HF patients and to guide their treatment. Patient hemodynamics can be... Abstract

Cited 21 times since 2024 (15.1 per year) source: EuropePMC

European heart journal, Volume 45, Issue 25, 1 1 2024, Pages 2201-2213 Coexisting atrial fibrillation and cancer: time trends and associations with mortality in a nationwide Dutch study. Chen Q, van Rein N, van der Hulle T, Heemelaar JC, Trines SA, Versteeg HH, Klok FA, Cannegieter SC

Background and aims: Coexisting atrial fibrillation (AF) and cancer challenge the management of both. The aim of the study is to comprehensively provide the epidemiology of coexisting AF and cancer. Methods: Using Dutch nationwide statistics, individuals with incident AF (n = 320 139) or cancer (n = 472 745) were identified during the period 2015-19. Dutch inhabitants without a history of AF (n = 320 135) or cancer (n = 472 741) were matched as control cohorts by demographic characteristics. Pre... Abstract

Cited 34 times since 2024 (24.4 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 116, Issue 4, 1 1 2024, Pages 939-947 Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy. Duarte JD, Thomas CD, Lee CR, Huddart R, Agundez JAG, Baye JF, Gaedigk A, Klein TE, Lanfear DE, Monte AA, Nagy M, Schwab M, Stein CM, Uppugunduri CRS, van Schaik RHN, Donnelly RS, Caudle KE, Luzum JA

Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in pharmacokinetic (e.g., CYP2D6) and pharmacodynamic (e.g., ADRB1, ADRB2, ADRA2C, GRK4, GRK5) genes have been studied in relation to beta-blocker exposure and response. We searched and summarized the strength of the evidence linking beta-blocker exposure and response with the six genes listed above. The level of eviden... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 8, 1 1 2024, Pages 1089-1098 Plasma lipidomics and coronary plaque changes: a substudy of the SMARTool clinical trial. Smit JM, Rocchiccioli S, Signore G, Michelucci E, Di Giorgi N, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Parodi O, Pelosi G, Scholte AJ

Aims: To date, no studies have investigated the association between lipid species and coronary plaque changes over time, quantitatively assessed by serial imaging. We aimed to prospectively determine the association between lipid species quantified by a plasma lipidomic analysis and coronary plaque changes according to composition assessed by a quantitative serial analysis of coronary computed tomography angiography (CTA). Methods and results: Patients with suspected coronary artery disease (CAD... Abstract