6128 results
Cited 18 times since 2007 (1 per year)
source: EuropePMC
Journal of thrombosis and haemostasis : JTH,
Volume 6, Issue 1, 25 4 2007, Pages 151-157
Development of a new test for the global fibrinolytic capacity in whole blood.
Rijken DC, Hoegee-de Nobel E, Jie AF, Atsma DE, Schalij MJ, Nieuwenhuizen W
Background: The development of global tests for the fibrinolytic capacity in blood is hampered by the low base-line fibrinolytic activity in blood, by the involvement of both plasmatic components and blood cells in the fibrinolytic system and by the loss of fibrinolytic activity as a result of the action of plasminogen activator inhibitor-1 (PAI-1). Objective: To develop a new test for the global fibrinolytic capacity (GFC) of whole blood samples. Methods and results: Collection of blood in thro...
Abstract
Cited 71 times since 2007 (4.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 100, Issue 11, 24 4 2007, Pages 1665-1670
Usefulness of QRS duration to predict response to cardiac resynchronization therapy in patients with end-stage heart failure.
Mollema SA, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ
Despite current selection criteria, 20% to 30% of patients treated with cardiac resynchronization therapy (CRT) do not benefit. It has been suggested that QRS duration may not be the optimal criterion to select patients for CRT. The objective of this study was to systematically evaluate the predictive value of QRS duration for response to CRT in a large group of consecutive patients. A total of 242 patients with heart failure scheduled for implantation of a CRT device were studied. Selection cri...
Abstract
Cited 472 times since 2007 (27.2 per year)
source: EuropePMC
Molecular & cellular proteomics : MCP,
Volume 7, Issue 2, 21 3 2007, Pages 282-289
A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins.
Rothbauer U, Zolghadr K, Muyldermans S, Schepers A, Cardoso MC, Leonhardt H
Green fluorescent proteins (GFPs) and variants thereof are widely used to study protein localization and dynamics. We engineered a specific binder for fluorescent proteins based on a 13-kDa GFP binding fragment derived from a llama single chain antibody. This GFP-binding protein (GBP) can easily be produced in bacteria and coupled to a monovalent matrix. The GBP allows a fast and efficient (one-step) isolation of GFP fusion proteins and their interacting factors for biochemical analyses includin...
Abstract
Cited 1486 times since 2007 (85.5 per year)
source: EuropePMC
Circulation,
Volume 116, Issue 22, 19 3 2007, Pages 2634-2653
Universal definition of myocardial infarction.
Thygesen K, Alpert JS, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction, Jaffe AS, Apple FS, Galvani M, Katus HA, Newby LK, Ravkilde J, Chaitman B, Clemmensen PM, Dellborg M, Hod H, Porela P, Underwood R, Bax JJ, Beller GA, Bonow R, Van der Wall EE, Bassand JP, Wijns W, Ferguson TB, Steg PG, Uretsky BF, Williams DO, Armstrong PW, Antman EM, Fox KA, Hamm CW, Ohman EM, Simoons ML, Poole-Wilson PA, Gurfinkel EP, Lopez-Sendon JL, Pais P, Mendis S, Zhu JR, Wallentin LC, Fernández-Avilés F, Fox KM, Parkhomenko AN, Priori SG, Tendera M, Voipio-Pulkki LM, Vahanian A, Camm AJ, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Morais J, Brener S, Harrington R, Morrow D, Lim M, Martinez-Rios MA, Steinhubl S, Levine GN, Gibler WB, Goff D, Tubaro M, Dudek D, Al-Attar N
Abstract
Cited 18 times since 2007 (1 per year)
source: EuropePMC
Circulation,
Volume 116, Issue 18, 15 3 2007, Pages 2018-2028
Resynchronization of separated rat cardiomyocyte fields with genetically modified human ventricular scar fibroblasts.
Pijnappels DA, van Tuyn J, de Vries AA, Grauss RW, van der Laarse A, Ypey DL, Atsma DE, Schalij MJ
Background: Nonresponse to cardiac resynchronization therapy is associated with the presence of slow or nonconducting scar tissue. Genetic modification of scar tissue, aimed at improving conduction, may be a novel approach to achieve effective resynchronization. Therefore, the feasibility of resynchronization with genetically modified human ventricular scar fibroblasts was studied in a coculture model. Methods and results: An in vitro model was used to study the effects of forced expression of t...
Abstract
Nature clinical practice. Cardiovascular medicine,
Volume 4, Issue 12, 9 2 2007, Pages 644-645
Can tissue Doppler imaging detect myocardial viability in patients with left ventricular dysfunction?
Bax JJ, Poldermans D
Abstract
Cited 106 times since 2007 (6.1 per year)
source: EuropePMC
Pflugers Archiv : European journal of physiology,
Volume 455, Issue 6, 2 1 2007, Pages 979-986
Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation.
Hessel MH, Atsma DE, van der Valk EJ, Bax WH, Schalij MJ, van der Laarse A
Elevated cardiac troponin-I (cTnI) levels have been demonstrated in serum of patients without acute coronary syndromes, potentially via a stretch-related process. We hypothesize that this cTnI release from viable cardiomyocytes is mediated by stimulation of stretch-responsive integrins. Cultured cardiomyocytes were treated with (1) Gly-Arg-Gly-Asp-Ser (GRGDS, n = 22) to stimulate integrins, (2) Ser-Asp-Gly-Arg-Gly (SDGRG, n = 8) that does not stimulate integrins, or (3) phosphate-buffered saline...
Abstract
Cited 32 times since 2007 (1.8 per year)
source: EuropePMC
Molecular and cellular biochemistry,
Volume 308, Issue 1-2, 2 1 2007, Pages 25-33
Modulation of calcification of vascular smooth muscle cells in culture by calcium antagonists, statins, and their combination.
Trion A, Schutte-Bart C, Bax WH, Jukema JW, van der Laarse A
Background: Vascular calcification is an organized process in which vascular smooth muscle cells (VSMCs) are implicated primarily. The purpose of the present study was to assess the effects of calcium antagonists and statins on VSMC calcification in vitro. Methods: VSMC calcification was stimulated by incubation in growth medium supplemented with 10 mmol/l beta-glycerophosphate, 8 mmol/l CaCl(2), 10 mmol/l sodium pyruvate, 1 micromol/l insulin, 50 microg/ml ascorbic acid, and 100 nmol/l dexameth...
Abstract
Cited 7 times since 2007 (0.4 per year)
source: EuropePMC
Pediatrics international : official journal of the Japan Pediatric Society,
Volume 49, Issue 5, 1 1 2007, Pages 600-602
Prothrombotic risk factors in children with hemiplegic cerebral palsy.
Senbil N, Yüksel D, Yilmaz D, Gürer YK
Background: The purpose of the present paper was to investigate the prevalence of prothrombotic risk factors associated with hemiplegic cerebral palsy (CP). Methods: Twenty-three hemiplegic CP patients were tested for inherited and acquired prothrombotic risk factors, except methylene tetrahydrofolate reductase (MTFR) polymorphism. Results: A total of 56.5% of patients had at least one coagulation abnormality and 13% of them had two. Four patients (8.7%) had infection and congenital heart diseas...
Abstract
Cited 117 times since 2007 (6.7 per year)
source: EuropePMC
Diabetes care,
Volume 30, Issue 10, 1 1 2007, Pages 2729-2736
Screening for coronary artery disease in patients with diabetes.
Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ, ADA
Coronary artery disease (CAD) accounts for a large fraction of the morbidity, mortality, and cost of diabetes. Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor-guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. Subsequent clinical trial results have not supported those recommendations. Since the prior consensus statement, newer imaging methods, such a...
Abstract
Cited 12 times since 2007 (0.7 per year)
source: EuropePMC
Acta cardiologica,
Volume 62, Issue 5, 1 1 2007, Pages 445-451
Myocardial blush grade: a predictor for major adverse cardiac events after primary PTCA with stent implantation for acute myocardial infarction.
Kaya MG, Arslan F, Abaci A, van der Heijden G, Timurkaynak T, Cengel A
Objectives: Optimal myocardial reperfusion is of great importance for survival of patients with AMI undergoing PTCA. According to the Thrombolysis In Myocardial Infarction (TIMI) 3 score, restoration of epicardial flow is achieved in the majority of patients. However, the myocardial blush grade (MBG) may offer additional information for survival. Therefore, we sought to determine whether myocardial blush grades were associated with MACE during follow-up in a high-risk AMI population undergoing p...
Abstract
Cited 24 times since 2007 (1.4 per year)
source: EuropePMC
Anesthesiology,
Volume 107, Issue 4, 1 1 2007, Pages 537-544
Guidelines for cardiac management in noncardiac surgery are poorly implemented in clinical practice: results from a peripheral vascular survey in the Netherlands.
Hoeks SE, Scholte op Reimer WJ, Lenzen MJ, van Urk H, Jörning PJ, Boersma E, Simoons ML, Bax JJ, Poldermans D
Background: The American College of Cardiology (ACC)/American Heart Association (AHA) guidelines for Perioperative Cardiovascular Evaluation for Noncardiac Surgery recommend an algorithm for a stepwise approach to preoperative cardiac assessment in vascular surgery patients. The authors' main objective was to determine adherence to the ACC/AHA guidelines on perioperative care in daily clinical practice. Methods: Between May and December 2004, data on 711 consecutive peripheral vascular surg...
Abstract
Cited 83 times since 2007 (4.8 per year)
source: EuropePMC
Radiology,
Volume 245, Issue 1, 1 1 2007, Pages 251-257
Metabolic imaging of myocardial triglyceride content: reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers.
van der Meer RW, Doornbos J, Kozerke S, Schär M, Bax JJ, Hammer S, Smit JW, Romijn JA, Diamant M, Rijzewijk LJ, de Roos A, Lamb HJ
Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age+/-standard error, 31 years+/-2.8 [range, 19-60 years]; body mass index, 19-30 kg/m...
Abstract
Cited 32 times since 2007 (1.8 per year)
source: EuropePMC
The Journal of general virology,
Volume 88, Issue Pt 10, 1 1 2007, Pages 2702-2709
Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains.
Herfst S, de Graaf M, Schrauwen EJA, Ulbrandt ND, Barnes AS, Senthil K, Osterhaus ADME, Fouchier RAM, van den Hoogen BG
Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate antigenic differences. The clinical impact of hMPV warrants the development of vaccines. Recombinant soluble fusion (F) proteins of prototype viruses of the two main lineages of hMPV that can be pr...
Abstract
Cited 1 times since 2007 (0.1 per year)
source: EuropePMC
Revista espanola de cardiologia,
Volume 60, Issue 10, 1 1 2007, Pages 1083-1091
[Coronary risk assessment in the management of patients undergoing noncardiac vascular surgery].
Schouten O, Bax JJ, Poldermans D
Patients scheduled for noncardiac vascular surgery are at significant risk of cardiovascular morbidity and mortality due to underlying symptomatic or asymptomatic coronary artery disease. This review will give an overview of current preoperative cardiac risk assessment strategies for patients undergoing noncardiac vascular surgery. Clinical cardiac risk scores are useful tools for the simple identification of patients with an increased perioperative cardiac risk. These risk scores include factor...
Abstract
Cited 18 times since 2007 (1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 50, Issue 17, 1 1 2007, Pages 1649-1656
Intensity of statin therapy in relation to myocardial ischemia, troponin T release, and clinical cardiac outcome in patients undergoing major vascular surgery.
Feringa HH, Schouten O, Karagiannis SE, Brugts J, Elhendy A, Boersma E, Vidakovic R, van Sambeek MR, Noordzij PG, Bax JJ, Poldermans D
Objectives: This study sought to examine whether higher statin doses and lower low-density lipoprotein (LDL) cholesterol are associated with improved cardiac outcome in vascular surgery patients. Background: Statins may have cardioprotective effects during major vascular surgery. Methods: In a prospective study of 359 vascular surgery patients, statin dose and cholesterol levels were recorded preoperatively. Myocardial ischemia and heart rate variability were assessed by 72-h 12-lead electrocard...
Abstract
Cited 95 times since 2007 (5.5 per year)
source: EuropePMC
Circulation,
Volume 116, Issue 17, 1 1 2007, Pages 1931-1941
CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.
Kraaijeveld AO, de Jager SC, de Jager WJ, Prakken BJ, McColl SR, Haspels I, Putter H, van Berkel TJ, Nagelkerken L, Jukema JW, Biessen EA
Background: Chemokines play an important role in atherogenesis and in ischemic injury and repair; however, prospective data on individual chemokines in unstable angina pectoris (UAP) are scarce. Therefore, we assessed chemokine patterns in a prospective cohort of patients with UAP. Methods and results: Plasma samples of 54 patients with Braunwald class IIIB UAP were examined at baseline for 11 chemokines and 5 inflammatory mediators via multiplex analysis. Levels of CC chemokine ligand (CCL)-5 (...
Abstract
Cited 69 times since 2007 (4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 50, Issue 16, 1 1 2007, Pages 1532-1540
Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling.
Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Gorcsan J, Bax JJ
Objectives: We sought to identify predictors of left ventricular (LV) remodeling after acute myocardial infarction. Background: Left ventricular remodeling after myocardial infarction is associated with an adverse long-term prognosis. Early identification of patients prone to LV remodeling is needed to optimize therapeutic management. Methods: A total of 178 consecutive patients presenting with acute myocardial infarction who underwent primary percutaneous coronary intervention were included. Wi...
Abstract
Cited 61 times since 2007 (3.5 per year)
source: EuropePMC
Journal of internal medicine,
Volume 262, Issue 6, 1 1 2007, Pages 678-689
Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study.
Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, Day NE, Wareham NJ, Kastelein JJ, Khaw KT
Background: We examined the relationship between granulocyte, lymphocyte and monocyte counts and risk of coronary heart disease (CHD) and cardiovascular disease (CVD) in men and women. There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD. Methods: This prospective study comprised 7073 men and 9035 women who were 45-79 years of age and were residents of Norfolk. United Kingdom. Results: During an average of 8 years of follow-up we identifi...
Abstract
Cited 17 times since 2007 (1 per year)
source: EuropePMC
The FEBS journal,
Volume 274, Issue 20, 26 4 2007, Pages 5425-5437
Aplysia temptin - the 'glue' in the water-borne attractin pheromone complex.
Cummins SF, Xie F, de Vries MR, Annangudi SP, Misra M, Degnan BM, Sweedler JV, Nagle GT, Schein CH
Temptin, a component of the complex of water-borne protein pheromones that stimulate attraction and mating behavior in the marine mollusk Aplysia, has sequence homology to the epidermal growth factor (EGF)-like domains of higher organisms that mediate protein-cell surface contact during fertilization and blood coagulation. In this work, recombinant temptin for structural and functional studies was produced in Escherichia coli using a cold shock promoter and purified by RP-HPLC. CD spectra confir...
Abstract
