Research

Publications

Below you can find a list of our published research.

6128 results

Cited 178 times since 2007 (10.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 15, 24 4 2007, Pages 1476-1483 Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. Gorcsan J, Tanabe M, Bleeker GB, Suffoletto MS, Thomas NC, Saba S, Tops LF, Schalij MJ, Bax JJ

Objectives: The purpose of this study was to test the hypothesis that a combined echocardiographic assessment of longitudinal dyssynchrony by tissue Doppler imaging (TDI) and radial dyssynchrony by speckle-tracking strain may predict left ventricular (LV) functional response to cardiac resynchronization therapy (CRT). Background: Mechanical LV dyssynchrony is associated with response to CRT; however, complex patterns may exist. Methods: We studied 190 heart failure patients (ejection fraction [E... Abstract

Cited 40 times since 2007 (2.3 per year) source: EuropePMC

Radiology, Volume 245, Issue 2, 21 3 2007, Pages 416-423 Evaluation of patients with previous coronary stent implantation with 64-section CT. Schuijf JD, Pundziute G, Jukema JW, Lamb HJ, Tuinenburg JC, van der Hoeven BL, de Roos A, Reiber JH, van der Wall EE, Schalij MJ, Bax JJ

Purpose: To prospectively evaluate the diagnostic accuracy of 64-section computed tomography (CT) for the assessment of in-stent or peristent restenosis, with conventional coronary angiography as the reference standard. Materials and methods: The study was approved by the medical ethics committee, and informed consent was obtained in all 50 enrolled patients (40 men, 10 women; mean age, 60 years +/- 11 [standard deviation]). In addition to conventional coronary angiography with quantitative coro... Abstract

Cited 58 times since 2007 (3.3 per year) source: EuropePMC

Atherosclerosis, Volume 197, Issue 1, 14 2 2007, Pages 57-63 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice. de Haan W, van der Hoogt CC, Westerterp M, Hoekstra M, Dallinga-Thie GM, Princen HM, Romijn JA, Jukema JW, Havekes LM, Rensen PC

Objective: In addition to lowering low-density lipoprotein (LDL)-cholesterol, statins modestly increase high-density lipoprotein (HDL)-cholesterol in humans and decrease cholesteryl ester transfer protein (CETP) mass and activity. Our aim was to determine whether the increase in HDL depends on CETP expression. Methods and results: APOE*3-Leiden (E3L) mice, with a human-like lipoprotein profile and a human-like responsiveness to statin treatment, were crossbred with mice expressing human CETP und... Abstract

Cited 57 times since 2007 (3.3 per year) source: EuropePMC

American heart journal, Volume 154, Issue 6, 14 2 2007, Pages 1160-1165 Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Ypenburg C, Sieders A, Bleeker GB, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). Methods: Thirty-one consecutive patients with heart failure (LV ejection fraction [LVEF] 26% +/- 7%, 35% nonischemic cardiomyopathy) underwent echocardiography during low-dose dobutamine infusion before CRT impla... Abstract

Cited 48 times since 2007 (2.7 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 1, 12 2 2007, Pages 166-173 Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ

Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal cou... Abstract

Cited 106 times since 2007 (6.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 12, 4 1 2007, Pages 1180-1188 Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing. Tops LF, Suffoletto MS, Bleeker GB, Boersma E, van der Wall EE, Gorcsan J, Schalij MJ, Bax JJ

Objectives: Speckle-tracking strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall strain and left ventricular (LV) dyssynchrony. Background: Recent studies have shown detrimental effects of RV pacing, possibly related to the induction of LV dyssynchrony. Methods: Fifty-eight patients treated with His bundle ablation and pacemaker implantation were studied. To assess the effect of RV pacing on time-to-peak radial... Abstract

Cited 139 times since 2007 (7.9 per year) source: EuropePMC

Circulation, Volume 116, Issue 13, 4 1 2007, Pages 1440-1448 Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline. Bleeker GB, Mollema SA, Holman ER, Van de Veire N, Ypenburg C, Boersma E, van der Wall EE, Schalij MJ, Bax JJ

Background: Recent studies have demonstrated that a positive response to cardiac resynchronization therapy (CRT) is related to the presence of preimplantation left ventricular (LV) dyssynchrony. The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown. Methods and results: One hundred consecutive patients scheduled for implantation of a CRT device were prospectively included if they met the following criteria: New York... Abstract

Cited 7 times since 2007 (0.4 per year) source: EuropePMC

Journal of child neurology, Volume 22, Issue 9, 1 1 2007, Pages 1143-1146 Devic's neuromyelitis optica in an infant case. Yuksel D, Senbil N, Yilmaz D, Yavuz Gurer YK

Devic's neuromyelitis optica was orginally described as an acute severe monophasic syndrome characterised by myelitis and optic neuritis. The mean age at onset was reported to be around 40 years, with a wide range. However, Devic's neuromyelitis optica has also been seen in children. Prognosis of the syndrome was poor, and no satisfactory treatment was known. This article reports a 23-month-old boy with acute myelitis and optic neuritis who was diagnosed with Devic's neuromyelitis... Abstract

Cited 13 times since 2007 (0.7 per year) source: EuropePMC

Human gene therapy, Volume 18, Issue 9, 1 1 2007, Pages 861-869 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA. Eefting D, Grimbergen JM, de Vries MR, van Weel V, Kaijzel EL, Que I, Moon RT, Löwik CW, van Bockel JH, Quax PH

For the successful application of RNA interference in vivo, it is desired to achieve (local) delivery of small interfering RNAs (siRNAs) and long-term gene silencing. Nonviral electrodelivery is suitable to obtain local and prolonged expression of transgenes. By intramuscular electrodelivery of a plasmid in which two opposing human polymerase III promoters (H1 and U6) drive the expression of siRNA constructs that form functional double-stranded siRNAs, in combination with in vivo bioluminescence... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

Journal of pediatric surgery, Volume 42, Issue 9, 1 1 2007, Pages E23-5 Anorectal impalement in a pediatric patient with transanal evisceration of small bowel. Bronkhorst MW, Wilde JC, Hamming JF, Heij HA

Rectal injuries in the pediatric population are most often attributed to accidental falls on offending objects, sexual abuse, or blunt trauma. Anorectal impalement is a rare injury, and as a result, specific knowledge or experience on the treatment of this type of injury in children is sparse. The extent of injury is often difficult to assess. Mostly, therapeutical decisions are based on general knowledge in adults. We present a case of accidental anorectal impalement in a child by a fall on the... Abstract

Cited 14 times since 2007 (0.8 per year) source: EuropePMC

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, Volume 30, Issue 3, 1 1 2007, Pages 325-331 Systolic and diastolic ventricular function in the normal and extra-embryonic venous clipped chicken embryo of stage 24: a pressure-volume loop assessment. Stekelenburg-de Vos S, Steendijk P, Ursem NT, Wladimiroff JW, Poelmann RE

Objectives: Fluid mechanical forces affect cardiac development. In the chicken embryo, permanent obstruction of the right lateral vitelline vein by clipping reduces the mechanical load on the embryonic myocardium, which has been shown to induce a spectrum of outflow tract anomalies. Insight into the effects of this intervention on the mechanical function of the developing myocardium could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. We... Abstract

Cited 4 times since 2007 (0.2 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 6, 1 1 2007, Pages 483-487 Carotid artery stenting versus endarterectomy in relation to perioperative myocardial ischemia, troponin T release and major cardiac events. Feringa HH, Hendriks JM, Karagiannis S, Schouten O, Vidakovic R, van Sambeek MR, Klein J, Noordzij P, Bax JJ, Poldermans D

Background: Carotid artery stenting (CAS) is less invasive than endarterectomy. This study examined differences in perioperative myocardial ischemia, troponin T release and clinical cardiac events in patients undergoing CAS compared with endarterectomy. Methods: In an observational study, CAS was performed in 24 and carotid endarterectomy in 44 patients. Before surgery, clinical risk factors were noted and dobutamine stress echocardiography was performed for cardiac risk assessment. Perioperativ... Abstract

Cited 25 times since 2007 (1.4 per year) source: EuropePMC

Current medical research and opinion, Volume 23, Issue 9, 1 1 2007, Pages 2235-2240 Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular disease and a low HDL-cholesterol. Bergheanu SC, Van Tol A, Dallinga-Thie GM, Liem A, Dunselman PH, Van der Bom JG, Jukema JW

Objective: Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL) associated enzyme involved in the protective mechanisms of HDL. Our aim was to compare the effect of treatment with rosuvastatin and atorvastatin on serum PON-1 activity. Methods: We performed a prespecified prospective study in 68 patients, part of a larger, multicentre randomized study--RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport). Patients aged 40-80 years, all men, with establ... Abstract

Cited 9 times since 2007 (0.5 per year) source: EuropePMC

Journal of vascular surgery, Volume 46, Issue 4, 30 5 2007, Pages 773-779 Assessment of three-dimensional stent-graft dynamics by using fluoroscopic roentgenographic stereophotogrammetric analysis. Koning OH, Kaptein BL, Garling EH, Hinnen JW, Hamming JF, Valstar ER, van Bockel JH

Objective: To validate the use of fluoroscopic roentgenographic stereophotogrammetric analysis (FRSA) for its feasibility and accuracy for measuring the three-dimensional dynamic motion of stent grafts. Methods: A digital biplane fluoroscopy setup was calibrated (Siemens Axiom Artis dBc). Stereo images were acquired of a static aortic model with a stent graft in different axial positions, imposed by a micromanipulator. The three-dimensional measurement error of FRSA was determined by comparing F... Abstract

Cited 37 times since 2007 (2.1 per year) source: EuropePMC

European journal of heart failure, Volume 9, Issue 10, 28 4 2007, Pages 1058-1063 Reverse ventricular remodelling after cardiac resynchronization therapy is associated with a reduction in serum tenascin-C and plasma matrix metalloproteinase-9 levels. Hessel MH, Bleeker GB, Bax JJ, Henneman MM, den Adel B, Klok M, Schalij MJ, Atsma DE, van der Laarse A

Background: In heart failure patients, cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling. Aim: The aim of this study was to evaluate whether changes in levels of circulating biomarkers of extracellular matrix metabolism correlate with the response to CRT. Methods and results: Clinical parameters, left ventricular (LV) volumes, and circulating levels of tenascin-C (TNC), matrix metalloproteinase-2 (MMP-2), MMP-9, and amino-terminal propeptide of brain natriuretic pe... Abstract

Cited 26 times since 2007 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 9, 27 4 2007, Pages 1479-1484 Comparison of the incidences of cardiac arrhythmias, myocardial ischemia, and cardiac events in patients treated with endovascular versus open surgical repair of abdominal aortic aneurysms. Feringa HH, Karagiannis S, Vidakovic R, Noordzij PG, Brugts JJ, Schouten O, van Sambeek MR, Bax JJ, Poldermans D

This study examines differences in cardiac arrhythmias, perioperative myocardial ischemia, troponin T release, and cardiovascular events between endovascular and open repair of abdominal aortic aneurysms (AAAs). Of 175 patients, 126 underwent open AAA repair and 49 underwent endovascular AAA repair. Continuous 12-lead electrocardiographic monitoring, starting 1 day before surgery and continuing through 2 days after surgery, was used for cardiac arrhythmia and myocardial ischemia detection. Tropo... Abstract

Cited 79 times since 2007 (4.5 per year) source: EuropePMC

Diabetes, Volume 56, Issue 12, 23 4 2007, Pages 2849-2853 Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects. van der Meer RW, Hammer S, Smit JW, Frölich M, Bax JJ, Diamant M, Rijzewijk LJ, de Roos A, Romijn JA, Lamb HJ

Objective: Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction. Because a very low-calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride content and cardiac function in healthy subjects. Research design and methods: Fourteen healthy nonobese men underwent (1)H-magnetic resonance spectroscopy (MRS) to determine myocardial and he... Abstract

Cited 94 times since 2007 (5.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 11, 23 4 2007, Pages 2310-2318 Natural killer cells and CD4+ T-cells modulate collateral artery development. van Weel V, Toes RE, Seghers L, Deckers MM, de Vries MR, Eilers PH, Sipkens J, Schepers A, Eefting D, van Hinsbergh VW, van Bockel JH, Quax PH

Objective: The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease. Here, we studied the role of lymphocytes in a murine model of hindlimb ischemia. Methods and results: Lymphocytes, detected with markers for NK1.1, CD3, and CD4, invaded the collateral vessel wall. Arteriogenesis was impaired in C57BL/6 mice depleted for Natural Killer (NK)-cells by anti-NK1.1 antibodie... Abstract

Cited 118 times since 2007 (6.7 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 8, 20 3 2007, Pages 1263-1270 Usefulness of tissue Doppler velocity and strain dyssynchrony for predicting left ventricular reverse remodeling response after cardiac resynchronization therapy. Yu CM, Gorcsan J, Bleeker GB, Zhang Q, Schalij MJ, Suffoletto MS, Fung JW, Schwartzman D, Chan YS, Tanabe M, Bax JJ

The assessment of systolic dyssynchrony by echocardiography is useful in predicting a favorable response to cardiac resynchronization therapy (CRT). Tissue Doppler velocity and tissue Doppler longitudinal strain have been suggested for this purpose. This study compared parameters of systolic dyssynchrony derived from these 2 imaging modalities for their predictive values of CRT response. Two hundred fifty-six patients from 3 different centers who received CRT were followed for 6 +/- 3 months. Pa... Abstract

Cited 10 times since 2007 (0.6 per year) source: EuropePMC

Cardiology, Volume 109, Issue 2, 14 2 2007, Pages 105-109 Fertility, pregnancy and delivery in women after biventricular repair for double outlet right ventricle. Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Hoendermis ES, Voors AA, Mulder BJ, van Dijk AP, Yap SC, Vliegen HW, Moons P, Ebels T, van Veldhuisen DJ

Objectives: To investigate outcome of pregnancy and fertility in women with double outlet right ventricle (DORV). Methods: Using 2 congenital heart disease registries, 21 female patients with DORV (aged 18-39 years) were retrospectively identified. Detailed recordings of each patient and their completed (>20 weeks gestation) pregnancies were recorded. Results: Overall, 10 patients had 19 pregnancies, including 3 spontaneous miscarriages (16%). During the 16 live birth pregnancies, primarily (... Abstract